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Showing papers on "Morpholine published in 1971"


Patent
10 Nov 1971
TL;DR: In this paper, the acid components are removed from fluids by contacting said fluid with a solution of a basic salt of an alkali or alkaline earth metal and an amine selected from the group consisting of 2-methylaminoethanol, 2-ethylamine, morpholine, pyrrolidone and derivatives thereof.
Abstract: Acidic components are removed from fluids by contacting said fluid with a solution of a basic salt of an alkali or alkaline earth metal and an amine selected from the group consisting of 2-methylaminoethanol, 2-ethylaminoethanol, morpholine, pyrrolidone and derivatives thereof. Preferably, the fluid is a gas and the acidic components are selected from the group consisting of CO2 and COS.

100 citations


Journal ArticleDOI
TL;DR: Experiments with N-methylaniline and morpholine have shown that thiocyanate, a normal constituent of human saliva, has a pronounced catalytic effect on the reaction between nitrite and secondary amines to form nitrosamines.

80 citations


Journal ArticleDOI
F. Leder1
TL;DR: In this paper, the rate of absorption and chemical reaction of carbon dioxide in potassium carbonate-bicarbonate buffer solutions was measured, at 80°C. The absorption rates measured were correlated with penetration and surface renewal theory.

41 citations


Journal ArticleDOI
TL;DR: Stability of 3morpholinosydnonimine (II), hydrochloride (I) and N-ethoxycarbonyl-3-morpholino-N-nitrosoaminoacetonitrile (VIII) were examined by photometry, potentiometry, thin-layer chromatography and spectroscopy.
Abstract: Stabilities of 3-morpholinosydnonimine (II), hydrochloride (I) and N-ethoxycarbonyl-3-morpholinosydnonimine (VIII) were examined by photometry, potentiometry, thin-layer chromatography and spectroscopy In alkaline solution VIII goes to ethanol, carbon dioxide and II, which successively decomposes to N-morpholino-N-nitrosoaminoacetic acid (V) and N-cyanomethylenaminomorpholine (VI) via N-morpholino-N-nitrosoaminoacetonitrile (III) In the processes of I=II=III, the initial equilibrium is very rapid and the consecutive cleavage is a spontaneous first order reaction at pH 3-7 or a base catalyzed reaction at pH 8-10 The initial process of is a base catalyzed first order hydrolysis of N-ethoxycarbonyl group Hydrolyses of I and VII in hydrochloric acid form morpholine, nitrogen, chloroacetic acid and ammonium chloride Photolyses of I and VII in acid solution at γ<320mμt give glycolic acid beside the products mentioned above Formation of I from III and hydrolysis of VI to N-aminomorpholine are acid catalyzed pseudo-first-order reactions Decomposition of III to VI seems to be a radical reaction

38 citations


Patent
15 Apr 1971
TL;DR: Paper, having a pH of about 5.0 or lower, is rendered resistant to the deterioration that is promoted by acidic conditions in paper by impregnating the paper, for example in the form of a book, with gaseous morpholine as mentioned in this paper.
Abstract: Paper, for example having a pH of about 5.0 or lower, is rendered resistant to the deterioration that is promoted by acidic conditions in paper by impregnating the paper, for example in the form of a book, with gaseous morpholine.

30 citations



Journal ArticleDOI
TL;DR: Morpholine-4-carbodithioate (mdtc) complexes of titanium(IV), vanadium(IV, chromium(III), manganese (III), iron(III) and cobalt(III, nickel (II), copper(II), zinc(II, and cadmium(II) have been characterized by analysis and magnetic and spectroscopic techniques.
Abstract: Morpholine-4-carbodithioate (mdtc) complexes of titanium(IV), vanadium(IV), chromium(III), manganese(III), iron(III), cobalt(III), nickel(II), copper(II), zinc(II), and cadmium(II) have been prepared and characterised by analysis and magnetic and spectroscopic techniques. The complexes are of the type M(mdtc)n, where n is the oxidation state of the metal ion except for vanadium(IV), where the complexing species is the VO2+ ion. Some adducts with the parent base morpholine are also reported.

27 citations


Patent
18 Jun 1971
TL;DR: A VAPOR SPACE inhIBited TURBINE OIL COMPRISES (1) A MAJOR AMOUNT of a MINERAL LUBRICATING OIL and (2) A SMALL AMOUNT OF EACH OF (A) ALKYL PHENOL, E.G., 2,6-DI-TERTIARY-BUTYL-4-METHYLPHENOL; (B) AMINE SALT OF A Diester Of O-PHOSPHORIC ACID.
Abstract: A VAPOR SPACE INHIBITED TURBINE OIL COMPRISES (1) A MAJOR AMOUNT OF A MINERAL LUBRICATING OIL AND (2) A SMALL AMOUNT OF EACH OF (A) AN ALKYL PHENOL, E.G., 2,6-DI-TERTIARY-BUTYL-4-METHYLPHENOL; (B) AN AMINE SALT OF A DIESTER OF O-PHOSPHORIC ACID, E.G., COCOAMINE DI-OXO-OCTYL ORTHOPHOSPHATE; (C) AN ALKENYL-SUBSTITUTED SUCCINIC ACID ANHYDRIDE, E.G., DODECENYL SUCCINIC ANHYDRIDE; (D) AN ACID ESTER OF (1) A DIMERIC ACID DERIVED FROM AN UNSATURATED FATTY ACID AND (2) A PARTIAL ESTER OF A FATTY ACID AND AN ALKITOL ANHYDRIDE, E.G., DIMERIZED LINOLEIC ACID-SORBITAN MONOOLEATE ACID ESTER; (E) CAPRYLIC ACID; AND (F) MORPHOLINE, A SULFURIZED MONOESTER SUCH AS SULFURIZED SPERM OIL MAY ALSO BE EMPLOYED.

21 citations


Journal ArticleDOI
TL;DR: In this paper, a series of alanine oligomers containing solubility-enhancing blocking groups were obtained through the use of 2-methoxy-[2-ethoxy-(2]- acetic acid (MEEA) and morpholine (Mo) as blocking groups for the N- and C-terminal ends, respectively.

20 citations


Patent
26 Apr 1971
TL;DR: In this paper, the authors describe the process for washing the GASEOUS ACIDIC COMPONENTS SUCH as CARBON DIOXIDE, HYDROGEN SULFIDE, and HYDRogENCYANIDE from a gas stream.
Abstract: THE WASHING AGENT INCLUDES A CARBOXYLIC ACID AMIDE OF MORPHOLINE PREFERABLY CONTAINING BETWEEN 1 AND 7 CARBON ATOMS IN THE CARBOXYLIC ACID CHAIN. THE GASEOUS ACIDIC COMPONENTS ARE ABSORBED BY THE CARBOXYLIC ACID AMIMDE OF MORPHOLINE AND MAY BE REMOVED THEREFROM BY DISTILLATION AT ABOUT 80*C. THE PROCESS FOR WASHING THE GASEOUS ACIDIC COMPONENTS SUCH AS CARBON DIOXIDE, HYDROGEN SULFIDE AND HYDROGENCYANIDE FROM A GAS STREAM INCLUDES TREATING THE GAS STREAM WITH A WASHING AGENT THAT ABSORBS AT LEAST A PORTION OF THE GASEOUS ACIDIC COMPONENTS. THE WASHING AGENT INCLUDES ONE OR MORE CARBOXYLIC ACID AMIDES OF MORPHOLINE IN A DILUTED OR UNDILUTED FORM. THE GASEOUS ACIDIC COMPONENTS ARE ABSORBED BY THE CARBOXYLIC ACID AMIDES OF MORPHOLINE AND CAN BE REMOVED THEREFROM BY DISTILLATION AT RELATIVELY LOW TEMPERATURES. THE CARBOXYLIC ACID AMIDES OF MORPHOLINE SELECTIVELY ABSORB BETWEEN 7 AND 8 VOLUMES OF HYDROGEN SULFIDE FOR EACH VOLUME OF CARBON MONOXIDE ABSORVE FROM THE GAS STREAM.

18 citations


Patent
09 Mar 1971
TL;DR: In this paper, the structural formula of benzopyrano pyridines has been revealed and they are used as bronchodilators for bronchial bronchiolase.
Abstract: In the above formula, R1 and R2 are hydrogen, hydroxy, lower alkoxy or lower alkyl or R1, R2 taken together with the carbon atoms to which they are attached form a methylenedioxy group. In addition, R1 can also be an oxyacetic acid or a derivative thereof, such as an ester, amide or a substituted amide. R3 is hydrogen or hydroxy, R4 is hydrogen or an omega-amino alkyl in which the omega-amino group can be further substituted with one or two alkyl groups or may be a part of a heterocyclic system such as morpholine or imidazoline. In addition, R4 may be an acetic acid or a derivative thereof such as an ester, amide or substituted amide. These compounds are prepared by known reactions. They are useful as bronchodilators. Substituted benzopyrano pyridines having the following structural formula are disclosed:

Journal ArticleDOI
TL;DR: In this paper, a comparative study of the donor ability of nitrogen and sulphur atoms in the cobalt-morpholine complexes has been made, and the results suggest that thiomorpholine is coordinated to cobalt through the nitrogen rather than the sulphur atom.
Abstract: The preparation and spectral and magnetic properties are reported for complexes of cobalt(II) with thiomorpholine. A comparative study has been made of the donor ability of nitrogen and sulphur atoms in the complexes. In an attempt to correlate the behaviour of thiomorpholine and morpholine with respect to divalent cobalt, work on cobalt(II)–morpholine complexes has been extended. The compounds CoX2L2, X = halide, L = thiomorpholine or morpholine, have been shown to be pseudo-tetrahedral, whereas when X = thiocyanate the compounds can be regarded as pseudo-octahedral involving thiocyanate bridging. I.r. results suggest that thiomorpholine is coordinated to cobalt through the nitrogen rather than the sulphur atom.

Patent
Paret Giancarlo1
29 Dec 1971
TL;DR: In this paper, a process for extracting aromatic hydrocarbons such as benzene, toluene and xylene with high selectivity from mixtures in which they are contained through extraction and/or extractive distillation with the aid of a solvent mixture including morpholine and another solvent such as an oxygen containing derivative of morpholine.
Abstract: A process is disclosed whereby aromatic hydrocarbons such as benzene, toluene and xylene are separated with high selectivity from mixtures in which they are contained through extraction and/or extractive distillation with the aid of a solvent mixture including morpholine and another solvent such as an oxygen containing derivative of morpholine and water, e.g. morpholinewater, morpholine-N-formyl morpholine and morpholine-N-formyl morpholine-water, in three main steps: (1) concentration of nonaromatic hydrocarbons to produce a stream free from aromatics; (2) purification of aromatics dissolved in rich solvent; and (3) recovery of the aromatics from the rich solvent.

Journal ArticleDOI
TL;DR: In this paper, a 5-coordinate (∼C 4 v ) geometry NMR contact shift and electron spin-nuclear spin coupling constants are tabulated and electron delocalization mechanisms are discussed.

Journal ArticleDOI
TL;DR: In this article, a trigonal bipyramidal structure with C-Sn-C bond angles of ca. 120° was given for the complexes formed between the compounds PrnSnCl3, Prn2SnCl2, and PhnsnCl4-n(n= 1-3) and the Lewis bases piperidine, morpholine, β-picoline, γ-poline, and isoquinoline.
Abstract: Complexes formed between the compounds PrnSnCl3, Prn2SnCl2, and PhnSnCl4–n(n= 1–3) and the Lewis bases piperidine, morpholine, β-picoline, γ-picoline, and isoquinoline have been studied by means of the Mossbauer effect. In several cases the signs of the quadrupole coupling constants, e2qQ, were determined. On this basis the complexes of Ph3SnCl have been assigned a trigonal bipyramidal structure with C–Sn–C bond angles of ca. 120°. The adducts of Ph2SnCl2 and Prn2SnCl2 with morpholine have a cis-arrangement of the organo-groups, whilst the other complexes have a trans-configuration. The nature of the bonding in these compounds and its influence on the Mossbauer parameters are also discussed.

Patent
09 Nov 1971
TL;DR: The shelf life of photographic developing compositions containing N-alkoxyalkyl substituted hydroxylamines is increased by addition of an oxyethylamino compound of the group consisting of triethanolamine, morpholine, N-ethylmorpholine, ethanol amine, 3-diethylamino-1,2-propanediol,N,N-dihydroxyethyl glycine and cellulose diethylaminethyl ether.
Abstract: The shelf life of photographic developing compositions containing N-alkoxyalkyl substituted hydroxylamines is increased by addition of an oxyethylamino compound of the group consisting of triethanolamine, morpholine, N-ethylmorpholine, ethanol amine, 3-diethylamino-1,2-propanediol,N,N-diethylaminoethanol, tris-2-propanolamine, N,N-dihydroxyethylglycine and cellulose diethylaminoethyl ether.

Journal ArticleDOI
TL;DR: A series of new 7-benz[c]acridinemethanols and 5,6-dihydro-7-benzman[c]-acridinecarboxylic acids were prepared as rigid, tetracyclic analogs of the antimalarial 2-phenyl-4-quinolinemethansols.

Patent
Karl Brack1
01 Jul 1971
TL;DR: The 1,3-PROPANE SULTONE ADDUCTS of TRIETHYLAMINE and QUINUCLIDINE as mentioned in this paper are the most common ones.
Abstract: CROSS-LINKABLE POLYMER COMPOSITIONS ARE DESCRIBED WHICH COMPRISE AN ETHYLENICALLY UNSATURATED POLYMER, THE SULTONE ADDUCT OF A TERTIARY AMINE AND A PRECURSOR OF A POLYFUNCTIONAL NITRILE N OR NITRILE IMINE. TYPICAL SULTONE ADDUCTS ARE THE 1,3-PROPANE SULTONE ADDUCTS OF TRIETHYLAMINE, TRIETHYLENEDIAMINE, N-METHYL MORPHOLINE AND QUINUCLIDINE. THESE COMPOSITIONS, WHICH CROSS-LINK ON HEATING, ARE USEFUL AS SEALANTS AND ADHESIVES AND IN COATING COMPOSITIONS.

Journal ArticleDOI
01 Apr 1971
TL;DR: In this article, the morpholine biguanide hydrochloride C6H13N5O has been solved by three-dimensional Patterson and heavy-atom Fourier syntheses.
Abstract: Crystals of morpholine biguanide hydrochloride, C6H13N5O. HC1, belong to the orthorhombic space groupPbca;a = 19·02 A,b = 9·92 A,c = 10·34 A andZ = 8. The structure has been solved by three-dimensional Patterson and heavy-atom Fourier syntheses. The hydrogen positions have been located from a three-dimensional difference Fourier synthesis. The positional coordinates of all the atoms and their temperature factors (anisotropic for non-hydrogen atoms and isotropic for hydrogen atoms) have been refined by three-dimensional least-squares methods. The finalR value is 0·087.

Journal ArticleDOI
TL;DR: The preparation of new tetraaminoethylenes was attempted by the reaction of chlorotrifluoroethylene (CTFE) with several amines in this paper.
Abstract: The preparation of new tetraaminoethylenes was attempted by the reaction of chlorotrifluoroethylene (CTFE) with several amines. It has been found that CTFE reacted with piperidine and morpholine to give tetrapiperidino- (TPE) and tetramorpholinoethylene (TME) in moderate yields respectively, although no tetraaminoethylenes were formed in the reactions with diethylamine, pyrrolidine, aniline, N-alkylaniline, and diphenylamine. Also, it has been made clear that the compounds whose structures were previously assigned to the tetraaminoethylenes, obtained from 1,1-dimethoxytrimethylamine or ethyl orthoformate and secondary amines are the corresponding triaminomethanes. It has been found that TPE and TME reacted with halogens, halogen-, nitrocompounds, and aromatic carboxylic acids to form mainly the corresponding oxamidinium salts.

Journal ArticleDOI
TL;DR: The orientation of the Noxidation of 1-methyl-4-p-nitrophenylpiperidine proceeds preferentially at the axial position in agreement with previous results as discussed by the authors.
Abstract: Some N-methyl- and N-t-butyl-piperidine and morpholine N-oxides are prepared. The N-oxide group shows a strong preference for the axial position compared with N-methyl as shown by n.m.r. chemical shifts and coupling constants. The N-oxides are highly hygroscopic and this hinders dipole-moment studies. The orientation of the N-oxidation of 1-methyl-4-p-nitrophenylpiperidine proceeds preferentially at the axial position in agreement with previous results.

Journal ArticleDOI
TL;DR: In this article, the first α-chlorodicarbanion structure is described and the generation and characterization of the first ε-chloridarbanions structure is reported.
Abstract: The generation and characterization of the first α-chlorodicarbanion structure is reported

Patent
22 Mar 1971
TL;DR: In this paper, a mixture of N-SUBSTITITUTED MORPHOLINE and SUCCINIMIDE was used as a solution to the problem of kidney failure.
Abstract: PROCESS FOR RECOVERING HIGHLY PURE AROMATIC SUBSTANCES FROM HYDROCARBON MIXTURES WHICH CONTAIN IN ADDITION TO THE AROMATIC SUBSTANCES VARYING AMOUNTS OF NON-AROMATIC SUBSTANCES BY LIQUID-LIQUID EXTRACTION ADVANTAGEOUSLY IN COMBINATION WITH AN AFTER ARRANGED EXTRACTIVE DISTILLATION CHARACTERIZED IN THAT THERE IS USED AS SELECTIVE SOLVENT A MIXTURE OF N-SUBSTITUTED MORPHOLINE AND N-SUBSTITUTED SUCCINIMIDE IN A MIXING RANGE OF BETWEEN 90 WT. PERCENT N-SUBSTITUTED MORPHOLINE AND 10 WT. PERCENT N-SUBSTITUTED SUCCINIMIDE AND 30 WT. PERCENT N-SUBSTITUTED MORPHOLINE AND 70 WT.-PERCENT N-SUBSTITUTED SUCCINIMIDE.

Journal ArticleDOI
TL;DR: An electrochemical procedure for halofunctionalization of olefins, which allows for introduction of both nitrogen and oxygen containing substituents, has been developed in this paper, without the need for silver salts or chemical oxidants, presently employed in analogous chemical routes.
Abstract: An electrochemical procedure has been developed for halofunctionalization of olefins, which allows for introduction of both nitrogen and oxygen containing substituents. The method obviates the need for silver salts or chemical oxidants, presently employed in analogous chemical routes. Thus 1-phenyl-2-butene on electrolysis in acetonitrile solution containing Et4NI, Et4NBr, or Et4NCl was converted to the corresponding haloamide derivative. In a related study, which extends the scope of electrochemical functionalization by nitrogen to negatively substituted olefins, dimorpholinization of trans-dibenzoylethylene was carried out by anodic oxidation of an acetonitrile solution of the olefin in presence of morpholine and Et4NI.

Patent
30 Dec 1971
TL;DR: In this article, the authors present a meeting of the MCLOYTIC and ANTITUSSIVE MEDICAMENT COMPRISING DERIVATIVES of THAIZOLIDINE CARBOXYLIC ACID of the FormulA, 2-R1,3-R3,4-(R2-CO-)THIAZolidine where R1 REPRESENTS HYDROGEN, AND ALKYL, ARYL, HYDROXY, ALKYLOXY, ARYLOXY.
Abstract: MUCLOYTIC AND ANTITUSSIVE MEDICAMENT COMPRISING DERIVATIVES OF THAIZOLIDINE CARBOXYLIC ACID OF THE FORMULA, 2-R1,3-R3,4-(R2-CO-)THIAZOLIDINE WHEREIN R1 REPRESENTS HYDROGEN, AND ALKYL, ARYL, HYDROXYL, ALKYLOXY, ARYLOXY, HETEROCYCLIC, AMINO OR CARBOYXLIC ACID OR ESTER, ALL OF THESE GROUPS CAPABLE OF BEING SUBSTITUTED, WHETHER SUBSTITUTED OR NOT; R2 REPRESENTS AN AMINO, HYDROXY, ALKYLOXY, ARYLOXY, HETEROCYCLIC, MONO- AND DIALKYLAMINO, -NHCH2OH, OR MORPHOLINE RADICAL, ALL OF THESE GROUPS CAPABLE OF BEING SUBSTITUTED, WHETHER SUBSTITUTED OR NOT; AND R3 REPRESENTS HYDROGEN, AN ALKYL, INCLUDING CYCLOALKYL HETEROCYCLIC, ARYL, CARBOXYLIC ACID OR CARBOXYLIC ACID ESTER GROUP.

Patent
Alessandro Ginnasi1, Carlo Rescalli1
23 Dec 1971
TL;DR: In this paper, a process is described where a group of intersecting DIOLEFINS, SUCH as ISOPRENE and BUTADIENE, are separated with high selectivly from mixtures of them through interaction and/or interactive divergence.
Abstract: A PROCESS IS DISCLOSED WHEREBY CONJUGATED DIOLEFINS, SUCH AS ISOPRENE AND BUTADIENE, ARE SEPARATED WITH HIGH SELECTIVELY FROM MIXTURES CONTAINING THEM THROUGH EXTRACTION AND/OR EXTRACTIVE DISTILLATION WITH THE AID OF AN AGENT CONSISTING OF MORPHOLINE AND ANOTHER SOLVENT SUCH AS AN OXYGEN CONTAINING DERIVATIVE OF MORPHOLINE AND WATER, E.G., MORPHOLINE-WATER, MORPHOLINE-N-FORMYL MORPHOLINE AND MORPHOLINE-N-FORMYL MORPHOLINE-WATER.

Journal ArticleDOI
TL;DR: In this paper, a preliminary pharmacological study of 3-methylbenzo[b]thiophen derivatives was carried out using N-bromosuccinimide in boiling carbon tetrachloride.
Abstract: Ethyl 5-amino-3-methylbenzo[b]thiophen-2-carboxylate was converted by standard methods into ethyl 3-methylbenzo[b]thiophen-2-carboxylate and its 4-bromo-, 5-bromo-, and 4,5-dibromo-derivatives.5-Amino-3-methylbenzo[b]thiophen was similarly converted into 5-cyano-, 5-carboxy-, and 5-ethoxycarbonyl-3-methylbenzo[b]thiophen.These 3-methylbenzo[b]thiophen derivatives were brominated with N-bromosuccinimide in boiling carbon tetrachloride, and some of the resulting 3-bromomethyl compounds were treated with thiourea or substituted thioureas to give a number of substituted S-2-ethoxycarbonyl-3-benzo[b]thenylthiouronium bromides. Other bromomethyl compounds reacted with diethylamine, morpholine, or pyrrolidine to give the corresponding tertiary amines, or with N-alkylethanolamines to give substituted 2-hydroxyethylamines, which gave the corresponding 2-chloroethylamines when treated with thionyl chloride in boiling chloroform. The results of a preliminary pharmacological study of these compounds are included.

Journal ArticleDOI
TL;DR: In this paper, the 3-dialkylaminopropiononitriles with hydrogen bromide gave stereoisomeric mixtures of the 4-bromocyclobutenes corresponding to compounds (I) and (II), along with the corresponding NNdialkyl-4bromo-6-dialkyl 6-dioxymidine-2-acetamides, and the corresponding 2,4-bis(dialklamino)-4-hydroxycyclobutene-1,3-dicarbonitri
Abstract: 4-Chloro-2,4-bis(diethylamino)- and -2,4-bis(dimethylamino)cyclobutene-1,3-dicarbonitrile [(I) and (II)], obtained from the corresponding 3-dialkylaminopropiononitriles and hydrogen chloride, suffered displacement of the chloro-substituent to give the triamines (III) and (IV) on treatment with morpholine and dimethylamine, respectively. Hydrolysis of the products gave the corresponding 2,4-bis(dialkylamino)-4-hydroxycyclobutene-1,3-dicarbonitriles (V) and (VI).Treatment of the 3-dialkylaminopropiononitriles with hydrogen bromide gave stereoisomeric mixtures of the 4-bromocyclobutenes corresponding to compounds (I) and (II), along with the corresponding NN-dialkyl-4-bromo-6-dialkylaminopyrimidine-2-acetamides. Similar treatment with dry bromine, however, afforded a complex mixture of cyclobutenes; the product distribution varied according to the molecular proportion of bromine used.

Journal ArticleDOI
TL;DR: In this article, the cis and trans isomers of 1-(p-bromobenzylidene)-2-indanone and their ketals were reported and the relative rations of the mono- and dibenzylidenes seemed to depend on the reaction conditions.

Journal ArticleDOI
TL;DR: In this paper, the GRIGNARD products were treated with formaldehyde and piperidine or morpholine effects aminomethylation at C-4 with the formation of the MANNICH bases.
Abstract: 4-Arylidene-2-phenyl-1-substituted-2-imidazolin-5-ones 1a–d react with organomagnesium compounds, in ether at room temperature, to yield, as the main isolable products, the 4-disubstituted-methyl derivatives 2a–h. On the other hand, 1a–d react with phenylmagnesium bromide in a boiling ether-benzene mixture to give, among the reaction products, 2a–d and the 4-diarylmethylene derivatives 3a–d. Spectral data of 2 and 3 are discussed. Treatment of the GRIGNARD products 2a–c with formaldehyde and piperidine or morpholine effects aminomethylation at C-4 with the formation of the MANNICH bases 6a–f.