Showing papers on "Morpholine published in 1972"

Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N-Nitroso Compounds

Abstract: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid. The extent of blocking depended on the compound nitrosated and on the experimental conditions. Urea and ammonium sulfamate were less effective as blocking agents. The possibility of in vivo formation of carcinogenic N-nitroso compounds from drugs could be lessened by the combination of such drugs with the ascorbic acid.

Photopolymerization process using combination of organic carbonyls and amines

Abstract: VARIOUS COMBINATIONS OF CERTAIN ORGANIC CARBONYL PHOTOSENSITIZER COMPOUNDS AND CERTAIN ORGANIC AMINE ACTIVATORS EXERT AN UNEXPECTED BENEFICIAL EFFECT ON THE PHOTOPOLYMERIZATION OF CERTAIN POLYMERIZABLE MONOMERS OR OLIGOMERS AND COATIN COMPOSITIONS CONTAINING THE SAME. THE SUITABLE CARBONYL COMPOUNDS CONTAIN A KETONIC OXYGEN, FOR EXAMPLE ONE CAN USE ACETOPHENONE OR XANTHONE, AND THE AMINES CAN BE PRIMARY, SECONDARY OR TERTIARY AMINES, FOR EXAMPLE, ONE CAN USE BUTYLDIETHANOLAMINE, TRIETHANOLAMINE, DI-N-BUTYLAMINE OR MORPHOLINE.

Adducts of Piperidine, Piperazine, Methylpiperazine, and Morpholine with Bis(β-Ketoenolates) of Nickel(II)

Abstract: The bis(β-ketoenolates)nickel(II) adducts of piperidine, piperazine, methylpiperazine, and morpholine are isolated in the solid state and investigated by magnetic measurements and electronic and i....

Montmorillonite complexes with dioxane, morpholine, and piperidine: mechanisms of formation*

Abstract: The absorption of dioxane, morpholine and piperidine from dilute aqueous solutions by Li-, Ca-, and Cu-montmorillonite is measured by means of a differential refractometer. This instru- ment measures small differences in the refractive indices of two liquids and provides a useful method for determining the amount of organic material removed from solution by the clay. Corrections are required for the effect of desorbed cations on the differential refraction measurements. Neutral molecules are absorbed in amounts related to the exchange capacity of the clay probably by cation- dipole interactions. The results are consistent with the formation of complexes Li+-R and R-Ca2+-R R 2+ 2+ for the three organic materials used; Cu ions behave like Ca ions for dioxane, but form > Cu2+-R R complexes with morpholine and piperidine. Under acid conditions, morpholine and piperidine form organic cations RH + which take part in cation exchange reactions and which are dominant at pH below about 5. Neutral molecule absorption also occurs by virtue of the presence of RH + ions on the clay which form RH+-R complexes (hemi-salt formation). When this last mechanism of absorption occurs, the total absorption is approximately twice that when a cation-dipole reaction or cation exchange alone operates. One-dimensional Fourier 001 syntheses of complexes in equilibrium with aqueous organic solutions indicate that water molecules are associated with the clay-organic com- plexes to the extent of about 5H20/unit cell.

Oven cleaning composition

Abstract: 1275740 Oven-drying compositions; aerosols S C JOHNSON & SON Inc 9 June 1969 [9 Sept 1968] 42876/68 Headings C4X and C5D An oven-cleaning composition comprises 1- 15% by weight of an amine component consisting of at least one of morpholine, morpholine derivatives, monoethanolamine, diethanolamine, triethanolamine, propanolamine, isopropanolamines, butanolamines, amylamines, ethylamines, benzylamines or butylisopropanolamine, water, air at least one surfactant and excluding caustic alkalies, wherein the surfactant concentration is 0A4-7A0% by weight Especially preferred surfactants are alkyl aryl ethylene oxide condensates and sulphate derivatives thereof, fatty alcohol sulphates neutralized with ammonia, fatty alcohol ethylene oxide condensates, alkyl ether sulphates, and fatty acid alkylol amide condensates A combination of at least one non-ionic and one anionic surfactant is preferred The cleaning composition may also contain an alkali-stable organic solvent such as a glycol, kerosene, 1,1,1 -trichlorethane and white spirit and when such solvents are present its optimum concentration is 5-25% by weight Conventional alkaline builders, such as phosphates, may also be present Additional ingredients are abrasives such as colloidal magnesium aluminium silicate, and solution thickeners, such as carboxymethyl cellulose, may also be present Conventional propellents, such as butane, dichlorodifluoromethane, dichlorotetrafluoroethane and nitrous oxide, may be used with the oven cleaning compositions In addition to the amine discussed above the composition may also contain ammonia, suitably in an amount 1-5% by weight, which assists in the saponification of fats and greases

Zur Koordination des Bors im triptych-Boroxazolidin (Triäthanolaminborat) und dessen Addukt mit Antimonpentachlorid

Abstract: Erganzende spektroskopische Untersuchungen an B(OC2H4)3N (1) und seinem neu hergestellten 1:1-Addukt mit Antimonpentachlorid bestatigten fur 1 eine pyramidale O3BN-Anordnung und wiesen fur das Addukt eine trigonal-planare BO3-Anordnung nach. Die thermische Zersetzung von 1 bei 240° ergibt in der Hauptsache Bortrioxid und einige Morpholinderivate. The Coordination of Boron in triptych-Boroxazolidine (Triethanolamine Borate) and its Addition Compound with Antimony Pentachloride Additional spectroscopic measurements of B(OC2H4)3N (1) and of the newly prepared 1 : 1-adduct with antimony pentachloride confirm a pyramidal O3BN-structure for 1 and a trigonal-planar BO3-structure for the adduct. The thermal decomposition of 1 yields B2O3 and some derivatives of morpholine.

Micellar effects on the hydrolysis and aminolysis of 2,4-dinitrophenyl sulphate

Abstract: Effects of micellar hexadecyltrimethylammonium bromide (CTAB), sodium dodecyl sulphate (NaLS), polyoxyethylene(20) nonylphenol (lgepal CO-850), 3-(dimethyldodecylammonio)-propane-1-sulphonate (DDAPS) and that of their co-micellar mixtures have been investigated on the nucleophilic reactivity of primary, secondary, and tertiary amines toward 2,4-dinitrophenyl sulphate. Observed second-order rate constants, k2,obs have been separated into those due to hydrolysis, K2,hyd, and to nucleophilic attack, K2,nuc. Micellar CTAB, DDAPS, and lgepal CO-850 enhance k2,hyd for the different amines from 4 to 33 fold, while micellar NaLS has no appreciable effect. A more dramatic result is the complete suppression of K2,nuc by micellar CTAB, DDAPS, and mixtures of CTAB and lgepal CO-850 for reactions of hydrazine and morpholine. Sensitivities of hydrolysis to amine basicity (Bronsted β-values) are greater in micellar CTAB, DDAPS, and lgepal CO-850 than in pure water.

Catalyzing urethane foam polymerization with 4-(2-dimethylaminomethyl)morpholine

Abstract: A PRECURSOR MIXTURE COMPRISING ORGANIC MATERIALS HAVING A PLURALITY OF ISOCYANATO GROUPS PER MOLECULE AND ORGANIC MATERIALS HAVING A PLUTALITY OF HYDROXY GROUPS PER MOLECULE, SAID PRECURSOR CONTAINING MODIFYING AGENTS SUCH AS SURFACTANTS, FILLERS, FOAMING AGENTS, DYES AND/OR SIMILAR MINOR COMPONENTS, IS TRANSFORMED INTO A USEFUL POLYURETHANE FOAM STRUCTURE BY RELIANCE UPON 4-(2-DIMETHYLAMINOETHYL)MORPHOLINE AS THE PRINCIPAL AMINE CATALYST FOR THE POLYMERIZATION.

Homogeneous catalytic activation of O–H and N–H bonds in organic molecules by ruthenium, osmium, rhodium, and iridium complexes

Abstract: H–D isotopic exchange between D2 and CH3COOH, CH3OH, C2H5OH or morpholine is observed in the presence of some RuII, OsII, RhI or IrI complexes at ambient conditions; analogous compounds of Pt0,II, Pd0,II, NiII, CoII and FeII are inactive.

Material for gel permeation chromatography

Abstract: The invention discloses cross-linked polymers which are useful for the separation of discrete chemical compounds by gel permeation chromatography. At least some of the repeating units of the backbone chains of the cross-linked polymers are bonded directly or indirectly to morpholine groups. The polymers have the advantage that they form gels in both water and a wide range of organic solvents.

Process for aryloxymethylmorpholine derivatives

Abstract: 1,260,886 Morpholine derivatives IMPERIAL CHEMICAL INDUSTRIES Ltd 29 May, 1970 [20 June, 1969; 13 Oct, 1969], Nos 31255/69 and 50130/69 Heading C2C Compounds I where R 1 and R 2 are H or alkyl; R 3 is H, alkyl, alkenyl, cycloalkyl or α-arylalkyl and X is optionally substituted aryl and their acid addition salts are prepared by cyclization of compounds II where Z is a displaceable radical, and if desired, followed by salt formation Compounds II may be produced in situ from interaction of an epoxide III with a compound IV Certain of compounds I are claimed per seviz those wherein R 1 , R 2 and R 3 are H and X is o-phenyl-phenyl; m-tolyl; 5,6,7,8-tetrahydronaphthyl-1; m-chlorophenyl ; m-phenoxyphenyl; 3,5-dimethyl phenyl; 2,5-dimethyl-phenyl; methoxyphenyl; or p-chlorophenyl; and those where R 1 and R 2 are H; R 3 is isopropyl and X is 2,4-dichlorophenyl; phenyl; m-chloro-phenyl or o-bromophenyl Intermediates isolated are 1-(o-ethoxyphenoxy) - 3 - # - hydroxyethylamino - 2-propanol, prepared from 1,2-epoxy-3(o-ethoxy-phenoxy)- propane and ethanolamine; and 2-benzylaminoethyl hydrogen sulphate, prepared from 2- benzylaminoethanol and H 2 SO 4

Tertiary amines with antalgic and antiinflammatory activity

Abstract: IN WHICH: R1 IS AN OH, ALKOXY RADICAL OF PREFERENCE METHOXY, ETHOX Y, O(CH2)2-N(CH3)2, OCH2-C6H4-PROPOXY, CYCLIC OR HETEROCYCLIC ARYLOXY, O-MONO (OR POLY) HYDROXYALKYL (OF PREFERENCE GLYCERINE), SINGLE AMINO (PARTICULARLY NHCH3, N(CH3)2, NH-(CH2)2OH, NH-(CH2)2N(CH3)2, MORPHOLINE), ALL GROUPS BEING ABLE TO BE SUBSTITUTED, BEING SUBSTITUTED OR NOT; N IS AN INTEGER BEING ABLE TO TAKE ALL VALUES FROM 0 TO 4; R2 IS THE HYDROGEN, AN ALKYL (PARTICULARLY METHYL) RADICAL, HYDROXY, ACID OR ESTER (PARTICULARLY COOH OR COOC2H5), ALKYLARYL (PARTICULARLY) BENZYL), CYCLIC OR HETEROCYCLIC ALKYL ACID OR ALKYL ESTER, OR AMINO, ALL GROUPS CAPABLE OF BEING SUBSTITUTED, BEING SUBSTITUTED OR NOT; R3 AND R4 ARE THE IDENTICAL OR DIFFERENT RADICALS, CHOSEN FROM AMONG THE FOLLOWING RADICALS: OH, HYDROGEN, HALOGEN, ALKYL, CYCLIC OR HETEROCYCLIC ARYLOXY, CYCLIC OR HETEROCYCLIC ALKOXYARYL, NITRO, SIMPLE OR SUBSTITUTED AMINO, ACID OR ESTER, ALL GROUPS CAPABLE OF BEING SUBSTITUTED AMINO, ACID OR ESTER, ALL GROUPS CAPABLE OF BEING SUBSTITUTED, BEING SUBSTITUTED OR NOT; R5 IS T HE HYDROGFEN, A HALOGEN, AN ALKYL GROUP, CYCLIC OR HETEROCYCLIC ARYL, ACID OR ESTER, CN, NITRO, AMINO, SIMPLE OR SUBSTITUTED CARBAMIDO (CONH2), ALL GROUPS BEING CAPABLE OF BEING SUBSTUTUTED, BEING SUBSTITUTED OR NOT; R6 AND R7 ARE THE IDENTICAL OR DIFFERENT RADICALS CHOSEN FROM AMONG THE FOLLOWING GROUPINGSS: H, ALKYL, CYCLIC OR HETEROCYCLIC ARYL, CYCLIC OR HETEROCYCLIC ALKYLARYL, HALOGEN, NITRO, SIMPLE OR SUBSTITUTED AMINO, ACID OR ESTER, OH, ALKOXY, ARYLOXY, C YCLIC OR HETEROCYCLIC ARYLOXY, CYCLIC OR HETEROCYCLIC O-ALKYLARYL. USEFUL MEDICAMENT, PARTICULARLY AS AN ANTI-INFLAMMATORY AND ANTALGIC AGENT, BASED ON TERTIARY AMINE DERIVATIVES, CHARACTERIZED BY THE FACT THAT THE TERTIARY AMINE DERIVATIVES COMPLY TO THE GENERAL FORMULA: 4-((R4,R3-PHENYL)-N(-CH(-R2)-(CH2)N-CO-R1)-),R5,R6,R7- QUINOLINE

Perchloroethylene vapor degreasing process

Abstract: A perchloroethylene vapor degreasing process wherein one of the following chemical components is added to the stabilizer system in perchloroethylene to improve its stability: 1. EPIBROMOHYDRIN 2. EPIBROMOHYDRIN AND ALLYL GLYCIDYL ETHER 3. EPIBROMOHYDRIN AND N-ethyl morpholine 4. EPIBROMOHYDRIN, ALLYL GLYCIDYL ETHER AND N-ethyl morpholine 5. N-ethyl morpholine 6. N-ethyl morpholine and allyl glycidyl ether.

Improvements in or relating to scale removal solvents and processes

Abstract: 1293440 Scale-removing composition F J QUATTRINI 8 Sept 1970 42893/70 Heading C7E [Also in Division E1] An aqueous composition for dissolving scale deposits comprises a partially neutralised amino polyacetic acid and an alkali metal or ammonium carbonate and/or bicarbonate and has pH 6A5 to 9A5. Mono- or poly-amino polyacetic acids may be used, e.g. EDTA,diethylene triaminepeutaacetic acid, N-hydroxyethyl amino diacetic acid or nitrilo-triacetic acid, preferred concentrations being 10-18 wt%. Partial neutralisation is achieved by adding, to pH 6A5 to 9A5, an inorganic alkali, typically 3-10% of NaOH, KOH, or NH 4 OH, or 2-12% of a hydroxyamine, e.g. mono, di, or triethanolamine, monoisopropanolamine, mixed isomers of isopropanolamine, morpholine, N- amino ethyl morpholine, or short-chain derivatives of these. The carbonate is preferably NH 4 , Na, or K carbonate or bicarbonate in amount 5-15%. The composition may optionally contain 1-6% of an acidulating and reaction-promoting agent such as HCHO, glyoxaldehyde, pyruvic aldehyde, acetaldehyde, propion-aldehyde, ammonium hydroxyacetate and/or ammonium sulphamate; 5-10% solubilising agent, e.g. urea, and 1-3% surfactant, e.g. polyethylene glycol or sodium alkyl or aryl sulphonate. The composition is used e.g. at 50-60‹F to remove scale such as CaSO 4 or sulphates or carbonates of Ca, Mg, or Ba from an oil well, e.g. casing, tubing, and pumps. The composition, applied under pressure, will also dissolve such materials from a rock matrix, thereby establishing new porosity and flow channels within a well.

Morpholine derivatives in the treatment of depression

Abstract: The disclosure relates to new 2-aryloxymethylmorpholine derivatives which possess antidepressant properties, and to processes for the manufacture of the said morpholine derivatives, to pharmaceutical compositions containing them, and to a method of preventing or relieving depression in warm-blooded animals including man. Typical of the morpholine derivatives disclosed is 2-(o-ethoxyphenoxymethyl)morpholine.

Amino- and dienamino-derivatives formed from adrenocortical steroids and heterocyclic bases

Abstract: Pyrrolidine, morpholine, and piperidine react directly with the 20-oxo-17α, 21-dihydroxy-side-chain of corticosteroids to give 21-amino-derivatives. l.r. and n.m.r. data indicate the presence of an internal hydrogen bond between the 17α-hydroxy-group and the C-21 nitrogen atom. The reaction at the 4-en-3-one system leads, as expected, to 3-amino-3,5-dienes. Reactivity at C-3 follows the order pyrrolidine > morpholine > piperidine and can be explained on the basis of resonance theory and steric effects. It is possible to prepare either 21-amino-or 3,21-diamino-derivatives. An s-trans-structure is postulated for the 3,5-diene system; a cross-conjugated system is excluded on the basis of n.m.r. data. Corticosteroids without a 17α-hydroxy-group react at C-21 only, under more drastic conditions. A possible explanation of the function of the 17-hydroxy-group is advanced.

Studies on the Syntheses of N-Heterocyclic Compounds. VI. Monosubstitution of 2-Phenyl-5, 8-dichloropyrimido [4, 5-d] pyridazine

Abstract: The reaction of 2-phenyl-5, 8-dichloropyrimido [4, 5-d] pyridazine (1) with a variety of primary and secondary amines afforded the corresponding mono-substituted compounds which were mixtures of two isomers, 5-substituted compound (5) and 8-substituted compound (6). Both isomers were separated and their structures were determined. Only one isomer was obtained by the reaction of 1 with morpholine or aniline under milder condition and its structure was proved to be 8-substituted compound. The reactivity of chlorine atoms at 5-and 8-position in 1 was discussed.

For cyclising 1-aryloxy-3 beta-substituted ethylamino-2-propanols

Abstract: A process for the manufacture of 2-aryloxymethyl morpholine derivatives, known to possess useful central nervous depressant activity, by the cyclisation of the corresponding 1-aryloxy-3Beta -substituted ethylamino-2-propanol derivative in which the Beta -substituent is a displaceable radical. This process avoids the use of hazardous complex metal hydrides employed in the prior art process.

Novel analgesics and molecular rearrangements in the morphine–thebaine group. Part XXVI. Some reactions of the thebaine–2-chloroacrylonitrile adduct

Abstract: Catalytic hydrogenation and treatment with nucleophiles (Grignard reagent, alkoxide ions, morpholine) results in loss of chlorine from the thebaine–2-chloroacrylonitrile adduct. The products of the latter reactions are derived from the C-7 carbanion (5) and the 7,8-unsaturated 7-carbonitrile (9), in most cases by processes involving rearrangements.

Reactions of thiolsulphonates with amines

Abstract: The equilibrium constants for the reaction of morpholine with methyl or t-butyl toluene-p-thiolsulphonates have been measured in acetonitrile–water (7 : 1,v/v) at 25 °C. Contrary to previous data they are 2·5 × 10–3 and 3·4 for the methyl and t-butyl substrates respectively. In the same solvent medium have been measured the reaction rates and the activation parameters of the nucleophilic displacement reaction of morpholine with the same substrates. The overall mechanism is discussed.

Mannich reactions on 1,2-diketones

Abstract: The product of a Mannich reaction on butane-2,3-dione depended upon the secondary base employed. With dimethylamine the product was 2,4-bisdimethylaminomethyl-2-methylfuran-3(2H)-one (II). With morpholine or N-methylpiperazine, a bis Mannich base derived from 2,5-dimethylbenzene-1,4-diol was obtained while pyrrolidine was the only base investigated which gave the expected open chain bis Mannich derivative.

Method for preparing n-amino alkylated morpholines

Abstract: Amines having the formula ##SPC1## E.g., dimethylamine, are reacted with amino alcohols having the formula, ##SPC2## E.g., hydroxyethyl morpholine, under vapor phase and dehydration conditions in the presence of a heterogeneous catalyst to obtain high yields of N-amino alkylated morpholine, e.g., N,N-dimethylaminoethyl morpholine. Similarly, amines having the formula ##SPC3## E.g., morpholine, are reacted with amino alcohols having the formula ##SPC4## E.g., dimethylethanolamine to obtain the desired substituted morpholines. In the above formulas R1 and R2 are each independently alkyl groups having 1 to 4 carbon atoms, R3, R4, R5 and R6 are each independently hydrogen, a methyl group or an ethyl group and R7 is an alkylene group having 1 to 4 carbon atoms.

3-Morpholino-2-cyanoacrylamide

Abstract: A compound WHEREIN R'' is hydrogen or lower alkyl, the compound being usable as an intermediate in the preparation of 4-hydroxypyrazolo (3,4d)pyrimidine (Allopurinol) and its useful relatives. A method of preparing WHICH COMPRISES REACTING R''C(OR)3, morpholine and cyanoacetamide where R'' is hydrogen or lower alkyl and R is lower alkyl.

Heterocyclic studies. Part XXVI. Cleavage of pyrimido [5,4-e]-as-triazin-5(6H)-one by nucleophiles

Abstract: Pyrimido [5,4-e-]-as-triazin-5(6H)-one was readily cleaved by morpholine or 1,1-dimethylhydrazine to yield 6-amino-5-morpholinocarbonyl-as-triazine or the corresponding 5-NN-dimethylcarbohydrazide The pyrimidotriazinone and hydroxylamine gave 6-hydroxypyrimide [5,4-e]-as-triazin-5(6H)-one, whereas the pyrimidotriazinone and methoxyamine gave methyl 6-(methoxyaminomethyleneamino)-as-triazine-5-carbohydroxamate