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Showing papers on "Morpholine published in 1988"


Journal ArticleDOI
J.-C. Wu1, Tanmaya Pathak1, W. Tong1, J.-M. Vial1, G. Remaud1, Jyoti Chattopadhyaya1 
TL;DR: Compounds described herein, with free 5'-hydroxyl function, are potential inhibitors of the HIV-reverse transcriptase promoted c-DNA synthesis.

61 citations


Journal ArticleDOI
TL;DR: In this paper, the 1,2-diarylethylenediamines with tertiary and primary amino groups are formed with no or only moderate diastereoselectivity (products 4a-d(Scheme 2) and 5e-e(scheme 3), respectively); the amine component may contain a strained ring or additional heteroatoms as in azetidin, bis(2-methoxyethyl)amine, piperazine, morpholine, and thiomorpholine (products 6a-e; Table 1).
Abstract: Scope and Limitations of the Reductive Coupling of Aromatic Aldimine Derivatives with Formation of 1,2-Diarylethylenediamine Units, Using Low-Valent Titanium Reagents Besides the adducts from lithium amides to aromatic aldehydes, iminium salts, animals, and N-silylimines of aromatic aldehydes are coupled by the black suspension obtained from TiCL4 and Mg turnings in tetrahydrofuran (THF). The 1,2-diarylethylenediamines with tertiary and primary amino groups thus obtained are formed with no or only moderate diastereoselectivity (products 4a–d(Scheme 2) and 5–e(Scheme 3), respectively); the amine component may contain a strained ring or additional heteroatoms as in azetidin, bis(2-methoxyethyl)amine, piperazine, morpholine, and thiomorpholine (products 6a–e; Table 1). By an in-situ procedure, ethylenediamines exclusively trans-diaryl-substituted piperazine and perhydro-1,4-diazepine derivatives (products 7a–f; Table 2). Enantiomerically pure monocyclic trans,cis-5-alkyl-2,-3-diaryl-piperazines and diazabicyclo[4.3.0]nonanes and -[4.4.0]decanes are obtained by employing suitable diamines prepared from the amino acids (S)-alanine, (S)-phenylalanine, (S)-proline and from (S,S)- or (R,R)-cyclohexane-1,2-diamine, respectively (products 11a–i, 7e; Table 4). The configuration of all products are derived from the high-field NMR spectra, some of which are discussed in detail (Figs. 1 and 2, Tables 3 and 5); all new compounds are fully characterized by their physical data. Depending upon the structure of the components employed, the yields of purified products range from as low as 7% to essentially quantitative.

60 citations


Journal ArticleDOI
Annemarie Polak1
TL;DR: Morpholine derivatives exhibit activity against fungi pathogenic to plants, animals, and hurnans and has shown high efficacy in experimental trichophytosis and vaginal candidiasis and is in clinical evaluation as a topical antimycotic.
Abstract: Morpholine derivatives exhibit activity against fungi pathogenic to plants, animals, and hurnans.l4 Fenpropimorph (FIG. 1) is highly effective against mildew and scab and is on the market as an agrofungicide, and the closely related derivative amorolfine (FIG. 1) has shown high efficacy in experimental trichophytosis and vaginal candidiasis and is now in clinical evaluation as a topical antimycotic.’

52 citations


Journal ArticleDOI
TL;DR: In this paper, the synthesis of 2-Bromo-thienyl glyoxal-2-phenylhydrazone (2-BHO-thiophene) is described.
Abstract: 2-Bromoacetylthiophene reacted with dimethylsulfide in ethanol to afford dimethylsulfonium bromide 2, which reacted with N-nitrosoacetanilide to give 2-bromo-thienylglyoxal-2-phenylhydrazone (3). 3 reacted with pyridine and with triphenylphosphine to give 4a and 4b, respectively. 3 reacted also with morpholine, sodium thiophenolate or potassium cyanide to afford the corresponding hydrazones 5a–c, respectively. 3 reacted also with potassium thiocyanate and with potassium selenocyanate to give the thiadiazoline 6a and selenadiazoline 6b. 3 is utilized also for the synthesis of several heterocycles via its reactions with malononitrile, benzoylacetonitrile, dibenzoylmethane, ω-benzenesulfonylacetophenone, N-arylmaleimides and benzalaniline. Structural assignments have been made on the basis of elemental analyses, spectral data and independent synthesis wherever possible.

43 citations


Journal ArticleDOI
TL;DR: A gram-positive, slowly growing rod effectively utilizing morpholine as the sole source of organic carbon, nitrogen, and energy was isolated from a mixed culture in a laboratory reactor.
Abstract: A gram-positive, slowly growing rod effectively utilizing morpholine as the sole source of organic carbon, nitrogen, and energy was isolated from a mixed culture in a laboratory reactor. The strain was tentatively identified as Mycobacterium aurum. Its growth characteristics at 20 degrees C and pH 6.5 were as follows: maximum specific growth rate, 0.052 h-1; half-velocity constant, 1.3 mg/liter; and yield, 0.37 g/g. The optimum temperature and pH were 31 degrees C and 6.0, respectively.

38 citations


Journal ArticleDOI
TL;DR: Determination a partir des mesures de densite pour les melanges morpholine + methanol, + benzene, + acetone, + chloroforme, + DMSO, + DMF
Abstract: Determination a partir des mesures de densite pour les melanges morpholine + methanol, + benzene, + acetone, + chloroforme, + DMSO, + DMF

28 citations


Journal ArticleDOI
TL;DR: In this article, the electrochemical oxidation properties of enamines of the cyclic ketones cyclo-pentanone, hexa-, hexanone and octanone were investigated with the aid of cyclic voltammetry and the lifetime of the intermediate cation radicals were shorter than 0.2 ms as determined by double potential step chronoamperometry.
Abstract: The electrochemical oxidation properties of enamines of the cyclic ketones cyclo-pentanone, -hexanone, -heptanone, and -octanone with the cyclic amines pyrrolidine, piperidine, 1-methylpiperazine (1-MP), morpholine (MO), hexa-, and hepta-methyleneimine are investigated with the aid of cyclic voltammetry. The oxidations are totally irreversible. The lifetime of the intermediate cation radicals are shorter than 0.2 ms as determined by double potential step chronoamperometry. The anodic peak potentials depend on the amine component in the order of ring sizes 5 < 7; 8 < 6 < 1-MP < MO. The variation of the ketone component shows no significant influence on the peak potentials. The ionization potentials of the enamines were measured and correlated with the anodic peak potentials.

26 citations


Journal ArticleDOI
TL;DR: The thermal stability of these compounds permits them to be used in the presence of cupric acetate for the alkylation of amines as mentioned in this paper, and Trialkylbismuth compounds can also be used for the same purpose.

26 citations


Journal ArticleDOI
TL;DR: In this article, the application of the allyl-ester moiety as protecting principle for the carboxy group of N-acetylneuraminic acid was described, where peracetylated allyl neuraminate 2 was synthesized by reacting the caesium salt of the acid 1 with allyl bromide.
Abstract: The application of the allyl-ester moiety as protecting principle for the carboxy group of N-acetylneuraminic acid is described. Peracetylated allyl neuraminate 2 is synthesized by reacting the caesium salt of the acid 1 with allyl bromide. Treatment of 2 with HCl in AcCl or with HF/pyridine gives the corresponding 2-chloro or 2-fluoro derivatives 3 and 4, respectively (Scheme 1). In the presence of Ag2CO3, the 2-chloro carbohydrate 3 reacts with di-O-isopropylidene-protected galactose 5 to give the 2–6 linked disaccharide with the α-D-anomer 6a predominating (α-D/β-D = 6:1; Scheme 2). Upon activation of the 2-fluoro derivative 4 with BF3 · Et2O, the β-D-anomer 6b is formed preferentially (α-D/β-D = 1:5). In further glycosylations of 4 with long-chain alcohols, the β-D-anomers are formed exclusively (see 10 and 11; Scheme 4). The allyl-ester moiety can be removed selectively and quantitatively from the neuraminyl derivatives and the neuraminyl disaccharides by Pd(0)-catalyzed allyl transfer to morpholine as the accepting nucleophile (see Scheme 5).

20 citations


Journal ArticleDOI
TL;DR: Tris (diethylamino)phosphine affords tertiary (amino) phosphines of pyrrolidine, piperidine, hexamethyleneimine, morpholine and N-methylpiperazine in nearly quantitative yields by transamination route.

17 citations


Patent
23 Feb 1988
TL;DR: In this paper, an osmium-catalyzed method of addition to an olefin was presented, where a chiral ligand, an organic solvent, water, and an amine derivative were combined.
Abstract: An osmium-catalyzed method of addition to an olefin. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, and aamine oxide and an osmium-containing compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, an amine derivative and an osmium-containing compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative or an amine derivative and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, N-methyl morpholine N-oxide and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.

Journal ArticleDOI
TL;DR: Mecanisme de la synthese des N-morpholine-, -piperidine- and -pyrrolidinecarboxylates de vinyle a partir d'acetylene, de dioxyde de carbone and des dialkylamines correspondantes.

Journal ArticleDOI
TL;DR: A nucleophilic substitution of 5bromotriazoloisoquinoline (3) and 7-bromo-3-methyltrieazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloenoquinolines (4a)-(4e), and of 7-substantituted trichloropyridines (7a-(7h) respectively.

Journal ArticleDOI
TL;DR: In this paper, the synthesis of Amino and Bisamino derivatives of octatetraynediamines has been studied in the context of bioinformatics, where the corresponding lithium 4-aminobutadiynides 3 with perchlorobutenyne 1, are dechlorinated by butyllithium to give the lithium 8-aminooctatetrynides 5a,b.
Abstract: Polyynes, 8. - Synthesis of Amino and Bisamino Derivatives of Octatetrayne The (7,8,8-trichloro-7-octene-1,3,5-triynyl)amines 4a,b, formed by the reaction of the corresponding lithium 4-aminobutadiynides 3 with perchlorobutenyne 1, are dechlorinated by butyllithium to give the lithium 8-aminooctatetraynides 5a,b. The latter react with chloromethyldiphenylsilane or with cyclohexanone to give the silylated and hydroxyalkylated compounds 6a,b and 7b, respectively. The unsymmetrically substituted octatetraynediamines 9a,b are obtained by treatment of the lithium compounds 5 with cyanogen bromide and by treatment of the formed bromoacetylenes 8 with piperidine or morpholine.

Patent
25 Jul 1988
TL;DR: Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*) can be used for the treatment of hypertension or angina in humans as discussed by the authors.
Abstract: Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used for the treatment of hypertension or angina in humans. A is pyrrolidine, piperidine or morpholine, Z is alkylene, alkenylene, oxygen or a sulfur atom and W is an oxygen or a sulfur atom.

Journal ArticleDOI
TL;DR: Results suggest that the sensitizing nature of DTDM is probably a reaction of its disulfide bond with the ‐SH & ‐NH2 groups of amino acid moieties, and suggest that in vitro tests may predict the sensitization potential of certain compounds.
Abstract: Previous studies in guinea pigs showed that DTDM, MMBT and MBT were sensitizing agents. The purpose of this study was to investigate the biochemical basis of this sensitization reaction. The reactions of representative amino acids, Cys, Lys & Gly, with morpholine, DTDM, MMBT & MBT were examined. New compounds were found between MMBT and all 3 amino acids. Additional new compounds were seen for Cys/MBT, Cys/DTDM, Lys/MBT & Gly/DTDM. No reaction was observed with morpholine. The new compounds were examined spectroscopically. Results suggest that the sensitizing nature of DTDM is probably a reaction of its disulfide bond with the -SH & -NH2 groups of amino acid moieties. The conjugation of Cys/MMBT may be via the same reaction mechanism. The -SH group of MBT may react either via oxidation and/or thioester formation with the carboxylate group of amino acids. These results also suggest that in vitro tests may predict the sensitizing potential of certain compounds.

Journal ArticleDOI
TL;DR: In this paper, dialkyl fumarates, alkyl N, N-diethylfumaramates, and N,N, N′,N′-tetraalkylfumamides with bulky substituents were homopolymerized in the presence of a radical initiator to give high molecular weight and less- or non-flexible substituted polymethylenes.
Abstract: Fumaric acid derivatives, dialkyl fumarates, alkyl N,N-diethylfumaramates, and N,N,N′,N′-tetraalkylfumaramides with bulky substituents were homopolymerized in the presence of a radical initiator to give high molecular weight and less- or non-flexible substituted polymethylenes. Dialkyl maleates were also homopolymerized by preceding isomerization to the respective dialkyl fumarates in the presence of both an azo initiator and morpholine (isomerization catalyst). N-Substituted maleimides underwent homopolymerization to give high molecular weight polymers, which have high thermal stability. These polymers were characterized as a new rigid polymer. Polymerization reactivities of the monomers and some properties of the resulting polymers are described and discussed.

Journal Article
TL;DR: It is concluded that nitrosamine formation in skin by this direct reaction between NO2 and the amine may be more important than the reaction of amines with NO2-derived NSA.
Abstract: Skin lipids of mice exposed to NO2 contain lipid-soluble nitrosating agent(s) (NSA) that react in vitro with amines to produce nitrosamines. To test whether this reaction occurs in skin, we exposed mice to 50 ppm NO2 for 4 h and, 20 h later, applied 25 mg morpholine or N -methylaniline to the skin, which was then analyzed for the corresponding nitrosamine. When morpholine was applied, mean N -nitrosomorpholine yield was only 0.3 nmol/mouse (not significant). When N -methylaniline was applied and mice were killed after 10–40 min, N -nitroso- N -methylaniline yield in the skin was 13–21 nmol/mouse of which 87% occurred in the hair. NSA formation when mice were exposed to 6.5 ppm NO2 was only 0.15% of that for exposure to 50 ppm NO2. NSA occurred mostly in surface lipids of the skin and its in vitro reaction to give nitrosamines was not inhibited by α-tocopherol. When morpholine was painted and mice were then exposed to 55 ppm NO2 for 30 min, the skins contained 19 nmol N -nitrosomorpholine/mouse, attributed to a direct reaction between NO2 and the amine. We concluded that nitrosamine formation in skin by this direct reaction may be more important than the reaction of amines with NO2-derived NSA.

Journal ArticleDOI
TL;DR: The reaction of Mannich du compose du titre avec la morpholine, piperidine ou piperazine as discussed by the authors, a reaction avec des amines primaires fournit des quinazolones-5.4b] azepine.
Abstract: Reaction de Mannich du compose du titre avec la morpholine, la piperidine ou la piperazine. La reaction avec des amines primaires fournit des quinazolones-5. Preparation d'un derive de la 9H-pyrimido-[5,4-b] azepine

Journal ArticleDOI
TL;DR: The 2-thionaphthylmethyl isocyanide (2-THIOCYANIDE) as discussed by the authors, which is derived from the novel N-(formamidomethyl)-N-benzyl morpholinium iodide (N-BNI) via transfer of elements of CH 2 NHCHO, is totally devoid of pervasive odour.

Journal ArticleDOI
TL;DR: In this paper, the effect of some morpholine and thiosemicarbazide derivatives on the dissolution of aluminium in 2M HCI has been investigated by using thermometric, weight loss and hydrogen evolution techniques.
Abstract: The inhibitive effect of some morpholine and thiosemicarbazide derivatives on the dissolution of aluminium in 2M HCI has been investigated by using thermometric, weight loss and hydrogen evolution techniques. The effect of the inhibitors on the protection efficiency and the corrosion rate were determined at various inhibitor concentrations and temperatures. It was observed that the percentage inhibition of aluminium increases with the increase of inhibitor concentration and decreases with rise of reaction temperature. Retardation of dissolution is due to weak adsorption of the additives on the metal surface. The order of inhibition efficiency of the inhibitors used depends on the number of adsorption sites in the molecule, their charge density and molecular size.

Patent
04 Mar 1988
TL;DR: Morpholine compounds of the formula: ##STR1## in which R1 is hydrogen, straight-chain or branched (C1 -C6)-alkyl which may contain a double bond, aralkyl, which may be substituted, (C5 -C7)-cycloalkyl or (C2 -C8)-acyl; and R2 is hydrogen or straight-chains or branched (C 1 -C5)-alkyls which may have double bonds.
Abstract: Morpholine compounds of the formula: ##STR1## in which R1 is hydrogen, straight-chain or branched (C1 -C6)-alkyl which may contain a double bond, aralkyl which may be substituted, (C5 -C6)-cycloalkyl or (C2 -C6)-acyl; and R2 is hydrogen, straight-chain or branched (C1 -C6)-alkyl which may contain a double bond, aralkyl which may be substituted, or (C2 -C3)-acyl; enantiomers and physiologically tolerable acid salts thereof. These compounds may be used therapeutically especially in the treatment of ischaemic syndromes and of cerebral ageing.

Patent
07 Mar 1988
TL;DR: In this article, a copolymer bearing allyl glyidyl ether or glycidyl methacrylate graft monomer has been functionalized with 2,5dimethyl aniline or 2,6-dimethyl morpholine.
Abstract: Lubricating oils of improved oxidative stability, dispersancy, and viscosity index contain ethylene-propylene copolymer bearing allyl glycidyl ether or glycidyl methacrylate graft monomer--which has been functionalized with 2,5-dimethyl aniline or 2,6-dimethyl morpholine.

Patent
07 Mar 1988
TL;DR: In this article, a method of inhibiting the growth of melanin-pigmented cells in a subject having need of such treatment is provided in which the subject is administered a cyclic amine which is selectively toxic to melanin piggmented cells.
Abstract: A method of inhibiting the growth of melanin-pigmented cells in a subject having need of such treatment is provided in which the subject is administered a cyclic amine which is selectively toxic to melanin-pigmented cells. Such cyclic amines include morpholine; piperazine; piperidine; N-methylpiperidine; N-methylpiperazine; 1,4 dimethylpiperazine; 2,5 dimethylpiperazine; piperidinopyridine and piperidino 1,2 propanediol for a time period and in a concentration sufficient to inhibit the growth rate of the cells without substantially affecting nonpigmented cells. Treatment of the subject by also administering a tyrosinase stimulator such as theophylline markedly increases the selective toxicity of the cyclic amine to the melanin-pigmented cells.

Journal ArticleDOI
TL;DR: The pyrano oxazine 1 react stepwise with morpholine undergoing replacement of the 7-chloro substituent yielding the 7morpholino analogue (4), then the pyrone ring was opened producing 5-morpholine carbonyl-4-oxo-3-substituted phenyl-2-thio-1,3-oxazine-6-ylacetomorpholid (5).
Abstract: Substituted aromatic isothiocyanates with malonyl chloride yield 7-chloro-3-substituted-3,4-dihydro-4,5-dioxo-2-thio-2H,5H-pyrano [3,4-e]-1,3-oxazine (1). Alkyl isothiocyanates with malonyl chloride yield a mixture of 7-chloro-3-alkyl-2-thio pyranooxazine (2) and the 2-oxo-analogue (3). The pyrano oxazine 1 react stepwise with morpholine undergoing replacement of the 7-chloro substituent yielding the 7-morpholino analogue (4), then the pyrone ring was opened producing 5-morpholino carbonyl-4-oxo-3-substituted phenyl-2-thio-1,3-oxazine-6-ylacetomorpholid (5). Finally the oxazine ring was opened yielding 2-substituted phenyl carbomyl-3-morpholino-N,N-glutaconoyldimorpholine (6). Ethanol react with compound 1 at any molar ration causing the opening of the pyrone ring and retain the oxazine ring. Mass spectra. 1H-n.m.r., u.v. and i.r. spectroscopic data provided information about the fine structures of the products.

Journal ArticleDOI
TL;DR: In the case of methanol, the N-(amino-thiocarbonyl)-benzimidates were formed as by-products as mentioned in this paper and the structure of the products was confirmed by analytical data and by chemical transformations.
Abstract: Reactions of N-(N′,N′-Dialkyl(aryl)amino-thiocarbonyl)benzimidoylchlorides with Potassium Thiocyanate The treatment of the title compound N-(amino-thiocarbonyl)-benzimidoylchloride 1 with potassium thiocyanate leads in dependence on the solvents (methanol, acetic acid, acetone) either to the 1,3,5-thiadiazine-2-thione 2a–d or to the ring opened isothiocyanate 4a, b. In the case of methanol the N-(amino-thiocarbonyl)benzimidates were formed as by-products. The structure of the products is confirmed by analytical data and by chemical transformations. 2a reacts with methyl iodide to form the 2-methylthio-6-morpholino-4-phenyl-1,3,5-thiadiaziniumiodide 3a. From 4a and water the N-(morpholino-thiocarbonyl)benzamide 5a arises. The reaction of morpholine with 4a yields the benzamidine 6a.

Book ChapterDOI
TL;DR: This chapter discusses the synthesis of the prototype peptide N α formyl-Met-Leu-Phe-OH (fMLP), a series of repetitive deprotections of t-Boc-amino acids or peptides using trifluoroacetic acid (TFA), subsequent neutralization with N-methyl morpholine (NMM), followed by coupling of the next t-Bsino acid using a rapid mixed anhydride method.
Abstract: Publisher Summary This chapter discusses the synthesis of the prototype peptide N α formyl-Met-Leu-Phe-OH (fMLP). The steps are a series of repetitive deprotections of t-Boc-amino acids or peptides using trifluoroacetic acid (TFA), subsequent neutralization with N-methyl morpholine (NMM), followed by coupling of the next t-Boc-amino acid using a rapid mixed anhydride method. Although several methods are available for the formylation of peptides, consistently excellent results have been obtained using the anhydride of isovaleryl chloride and formic acid. The same general protocol is used for the synthesis of the antagonists. The prototype analog is the pentapeptide, t-Boc-Phe-Leu-Phe-Leu-Phe-OH. The final step, however, is a catalytic hydrogenolysis to yield the t-Boc-free acid form of the desired peptide. Although the synthesis for the pentapeptide is presented, the tripeptide t-Boc-Phe-Leu-Phe-OH is also fully active and only slightly less potent. No solid-phase synthesis for the antagonists has been reported.

Journal ArticleDOI
TL;DR: In this paper, the effect of various hydrogen-bond acceptors on the reactions of 1-chloro and 1-fluoro-2,4-dinitrobenzenes with morpholine in benzene at 30°C has been investigated.
Abstract: The effect of various hydrogen-bond acceptors on the reactions of 1-chloro- and 1-fluoro-2,4-dinitrobenzenes with morpholine in benzene at 30°C has been investigated. The reaction of the chloro substrate is not base-catalysed and the additives produced no acceleration in the concentrations employed. The reaction of the fluoro substrate is base-catalysed. The addition of hydrogen-bond acceptors frequently leads to accelerations which vary linearly with the concentration of the acceptor. An approximately linear relationship exists between the logarithm of the slope of these correlations and the hydrogen-bonding parameter pkHB. These effects are interpreted as electrophilic catalysis, by the heteroconjugates of the acceptors with the conjugate acid of morpholine, of the ratedetermining decomposition of the intermediate in these reactions.

Patent
04 Jul 1988
TL;DR: In this paper, a compound of the formula I (I) in which A is one of the groups of the formulae +TR in which B is -O-, -S-, -SO2-, -N=N-, -CH2-, CH=CH-, -CONH-, -NHCONH- or -NH-CO-, Q is-O-or-NH- and Z is -Or-Or-NH -and R and R are independently of each other hydrogen, halogen, C 1-C4-alkyl, C1-
Abstract: Composition of matter containing (a) a compound of the formula I (I) in which A is one of the groups of the formulae +TR in which B is -O-, -S-, -SO2-, -N=N-, -CH2-, -CH=CH-, -CONH-, -NHCONH-, or -CONHNHCO-, Q is -O- or -NH- and Z is -O- or -S- and R and R' are independently of each other hydrogen, halogen, C1-C4-alkyl, C1-C4-alkoxy or phenoxy, and (b) a compound of the formula II (II) in which A' is as defined above for A, D is hydrogen, amino or a group of the formula III (III) E is -O- or -S-, T1, T2 and T3 independently of one another are chlorine or a group -ET', T' is a group of the formulae X(+) is H(+) or a group of the formulae Mn(+)/n or N beta (R1)(R2)(R3)(R4), Mhu n(+) is an n-valent metal cation, n is 1, 2 or 3, R1, R2, R3 and R4 are independently of one another hydrogen, C1-C18-alkyl, C5-C6-cycloalkyl, unsubstituted or C1-C18-alkyl-substituted phenyl or R3 and R4 together with the N atom form a pyrrolidine, imidazolidine, piperidine, piperazine or morpholine radical, or R2, R3 and R4 together with the N atom form a pyrrole, pyridine, picoline, pyrazine, quinoline or isoquinoline radical and Y is hydrogen, halogen, methyl, methoxy or amino Pigment mixtures of this type, in particular when used in paints, are distinguished in particular by increased tinctorial strength and high luster and especially by improved rheology

Journal Article
TL;DR: In this paper, the reaction d'acetyl-3 trimethyl-1,5,5 pyrrolidinedinedione-2,4 avec des derives du benzaldehyde en presence d'amines secondaires, d'acide ou de base forte
Abstract: Reaction d'acetyl-3 trimethyl-1,5,5 pyrrolidinedione-2,4 avec des derives du benzaldehyde en presence d'amines secondaires, d'acide ou de base forte