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Morpholine

About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.


Papers
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Journal ArticleDOI
TL;DR: The condensation reactions of partly substituted spiro-cyclotriphosphazenic lariat (PNP-pivot) ethers produce fully substituted morpholino and 1,4-dioxa-8-azaspiro[4,5]deca (5 and 6) phosphazenes, which are the new examples of the spira-cyclophosphazen ether derivatives with N(2)O(x) (x=2 and 3) donor type

25 citations

Journal ArticleDOI
TL;DR: A facile and efficient two-step synthetic route for p-substituted tris(2-pyridylmethyl)amine (TPMA) ligands to form Cu complexes with the highest activity in Atom Transfer Radical Polymerization (ATRP) to-date is reported.
Abstract: A facile and efficient two-step synthesis of p-substituted tris(2-pyridylmethyl)amine (TPMA) ligands to form Cu complexes with the highest activity to date in atom transfer radical polymerization (ATRP) is presented. In the divergent synthesis, p-Cl substituents in tris(4-chloro-2-pyridylmethyl)amine (TPMA3Cl ) were replaced in one step and high yield by electron-donating cyclic amines (pyrrolidine (TPMAPYR ), piperidine (TPMAPIP ), and morpholine (TPMAMOR )) by nucleophilic aromatic substitution. The [CuII (TPMANR2 )Br]+ complexes exhibited larger energy gaps between frontier molecular orbitals and >0.2 V more negative reduction potentials than [CuII (TPMA)Br]+ , indicating >3 orders of magnitude higher ATRP activity. [CuI (TPMAPYR )]+ exhibited the highest reported activity for Br-capped acrylate chain ends in DMF, and moderate activity toward C-F bonds at room temperature. ATRP of n-butyl acrylate using only 10-25 part per million loadings of [CuII (TPMANR2 )Br]+ exhibited excellent control.

25 citations

Journal ArticleDOI
TL;DR: Four compounds designed and synthesized 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f]triazin-4-yl)morpholine derivatives showed selectivity over 15 tested protein kinases and anti-proliferative activity at micromolar concentration against several cancer cell lines.

25 citations

Journal ArticleDOI
TL;DR: Zinc metal mediated simple and efficient alkylation of cyclic secondary amines e.g., piperazines and morpholine with allyl bromide was described in this paper.

25 citations

Journal ArticleDOI
TL;DR: In this article, the kinetics of the reaction of benzylidenemalonodialdehyde with piperidine, morpholine, n-butylamine, 2-methoxyethylamine and semicarbazide have been determined in 50% aqueous Me 2 SO at 20 o C. Intrinsic rate constants (κ 0 =κ 1 =κ −1 ) and the pK a of T A ±, were determined for all the amines.
Abstract: The kinetics of the reaction of benzylidenemalonodialdehyde with piperidine, morpholine, n-butylamine, 2-methoxyethylamine, glycinamide, glycine ethyl ester, cyanomethylamine, and semicarbazide have been determined in 50% aqueous Me 2 SO at 20 o C. The reaction leads to a zwitterionic adduct, PhCH(RR'NH + )C(CHO) 2 − (T A ± ), that is in fast acid-base equilibrium with the anionic adduct, PhCH(RR'N)C(CHO) 2 − (T A − ). With strongly basic amines at high pH there is also attack of the amine on one of the carbonyl groups, which acts as a rapid preequilibrium. Rate constants for the formation of T A ± (κ 1 ) and its reverse (κ −1 ), as well as equilibrium constants (K 1 =κ 1 /κ −1 ) and the pK a of T A ± , were determined for all the amines. Intrinsic rate constants (κ 0 =κ 1 =κ −1 ) and the pK a of T A ± , were determined for all the amines. Intrinsic rate constants (κ 0 =κ 1 =κ −1 when K 1 =1) were calculated

25 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202385
2022177
202191
2020135
2019129
2018143