Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: In this paper, the effect of mixing 2-amino-2-methyl-1-propanol (AMP) with faster reacting secondary amines (methyl monoethanolamine (MMEA) and morpholine (MORPH)) on the kinetics of the reaction with carbon dioxide in aqueous media has been studied at 298, 303, 308 and 313 K over a range of blend composition and concentration.
24 citations
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TL;DR: In this article, the authors studied the nitrosation of piperidine, morpholine, pyrrolidine, N-methylpiperazine, N,N-dimethylethylenediamine and diethylamine by 2-bromoethyl nitrite.
Abstract: We studied the nitrosation of piperidine, morpholine, pyrrolidine, N-methylpiperazine, N,N‘-dimethylethylenediamine and diethylamine by 2-bromoethyl nitrite, 2,2-dichloroethyl nitrite, 2,2,2-trichl...
24 citations
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TL;DR: Morpholine based Schiff base ligand and its metal(II) complexes of the type [ML]X2 have been synthesized and characterized by elemental analysis, by means of 1H NMR, FT-IR, UV-Visible, mass and ESR spectroscopic method.
24 citations
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TL;DR: A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives bearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity by assaying the ability to antagonize the von Bezold-Jarisch reflex in rats.
Abstract: A new series of 2-alkoxy-4-amino-5-chlorobenzamide derivatives bearing five- to seven-membered heteroalicyclic rings in the amine moiety was synthesized and evaluated for serotonin-3 (5-HT 3 ) receptor antagonistic activity by assaying the ability to antagonize the von Bezold-Jarisch reflex in rats. The five- to seven-membered heteroalicycles comprise pyrrolidine, morpholine, 1,4-thiazine, piperidine, piperazine, 1,4-oxazepine, 1,4-thiazepine, azepine, and 1,4-diazepine rings. Among them, some benzamide derivatives having a 1,4-diazepine ring showed a potent 5-HT 3 receptor antagonistic activity. In particular, 4-amino-5-chloro-N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxybenzamide (96) and the 1-benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT 3 receptor antagonistic activity without 5-HT 4 receptor binding affinity.
23 citations
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TL;DR: It was concluded that growth of Mycobacterium sp.
Abstract: A cytochrome P450 and an iron-sulfur protein, whose expression was specifically induced during growth of Mycobacterium sp. strain HE5 on morpholine as the sole source of carbon, nitrogen, and energy were purified to apparent homogeneity. Due to the lack of enzymatic activity, carbon monoxide difference spectra and determination of the acid-labile sulfur, respectively, were used to detect the proteins during purification. The cytochrome P450, designated P450mor, was characterized as a monomer with an apparent molecular mass of 44.7 kDa. The amino acid sequence of an internal peptide comprising 19 amino acids was identical to the sequence derived from a gene encoding a cytochrome P450 from Mycobacterium smegmatis mc2155 suggested to be involved in the utilization of piperidine and pyrrolidine. The iron-sulfur protein was characterized as a ferredoxin exhibiting a molecular mass of 6.8 kDa and named Fdmor. An identity of 48–77% was obtained for the 30 N-terminal amino acids of Fdmor and the corresponding sequences of different 3Fe-4S-ferredoxins known to be involved in P450-dependent reactions. From these data we concluded that growth of Mycobacterium sp. strain HE5 on morpholine led to the expression of a cytochrome P450-dependent monooxygenase system composed of at least two different proteins.
23 citations