Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: In this article, the preparation and characterization of new complexes of palladium (II) and platinum (II), with some heterocyclic containing dithiocarbamate ligands, such as piperidine-, morpholine-, and thiomorpholine-dithiocalaramate, their methyl esters and corresponding thiouramdisulphides, were reported.
23 citations
Patent•
31 Oct 2012
TL;DR: In this article, the desflurane bacteria amide compound compound bactericide (DES-BAC) was presented, and the active ingredients of the DESFLURANE BAC compound were desFLurane amide and (E, Z) - 4-[3- (4-chlorphenyl) 3-(3, 4-dimethoxy phenyl) acrylyl] morpholine.
Abstract: The invention provides a desflurane bacteria amide compound bactericide The active ingredients of the desflurane bacteria amide compound bactericide are desflurane bacteria amide and (E, Z) - 4-[3- (4-chlorphenyl) 3-(3, 4-dimethoxy phenyl) acrylyl] morpholine In the desflurane bacteria amide compound bactericide, 1-50% of desflurane bacteria amide is contained, and 1-45% of (E, Z) - 4-[3- (4-chlorphenyl) 3-(3, 4-dimethoxy phenyl) acrylyl] morpholine is contained The desflurane bacteria amide compound bactericide has the advantages of improvement on sterilizing effect and efficiency
23 citations
TL;DR: In this paper, a compound with an (R)-morpholine-2-propionic acid at the C6 position of its dihydropyrimidine core ring was found to exhibit no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at the high concentration of 10 μM.
Abstract: The inhibition of hepatitis B virus (HBV) capsid assembly is a novel strategy for the development of chronic hepatitis B (CHB) therapeutics. On the basis of the preclinical properties and clinical results of GLS4, we carried out further investigation to seek a better candidate compound with appropriate anti-HBV potency, reduced hERG activity, decreased CYP enzyme induction, and improved pharmacokinetic (PK) properties. To this end, we have successfully found that morpholine carboxyl analogues with comparable anti-HBV activities to that of GLS4 showed decreased hERG activities, but they displayed strong CYP3A4 induction in a concentration-dependent manner, except for morpholine propionic acid analogues. After several rounds of modification, compound 58 (HEC72702), which had an (R)-morpholine-2-propionic acid at the C6 position of its dihydropyrimidine core ring, was found to display no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at the high concentration of 10 μM. In particular, it demonstrated a good systemic exposure and high oral bioavailability and achieved a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model and has now been selected for further development.
23 citations
TL;DR: The reactions of the title thionocarbonates with a series of secondary alicyclic amines are subjected to a kinetic investigation and a mechanistic scheme is proposed with the formation of a zwitterionic tetrahedral intermediate which can transfer a proton to an amine to give an anionic intermediate.
Abstract: The reactions of the title thionocarbonates (6, 7, and 8, respectively) with a series of secondary alicyclic amines are subjected to a kinetic investigation in 44 wt % ethanol−water, 25.0 °C, ionic strength 0.2 M (KCl). Under excess amine, pseudo-first-order rate coefficients (kobsd) are obtained for all reactions. Reactions of substrates 6 and 7 with piperidine and of thionocarbonate 8 with the same amine and piperazine, 1-(2-hydroxyethyl)piperazine, and morpholine show linear kobsd vs [amine] plots, with slopes (k1) independent of pH. On the other hand, these plots are nonlinear upward for the reactions of substrates 6 and 7 with all the amines, except piperidine, and also for the reactions of compound 8 with 1-formylpiperazine and piperazinium ion. For all these reactions a mechanistic scheme is proposed with the formation of a zwitterionic tetrahedral intermediate (T±), which can transfer a proton to an amine to give an anionic intermediate (T-). Rate and equilibrium microcoefficients of this scheme, ...
23 citations
TL;DR: In this article, a mixture of tetraethylammonium hydroxide and morpholine was used as structure-directing agents to synthesize SAPO-34 molecular sieves.
Abstract: Crystals of SAPO-34 molecular sieves were synthesized under hydrothermal conditions using tetraethylammonium hydroxide, morpholine and a mixture of them as structure-directing agents. The properties of the catalysts were characterized using XRD, SEM, BET, ICP, FT-IR, 29Si MAS NMR and NH3-TPD. Characterization studies showed that using a mixed template lead to a reduction in particle size and an increase in external surface area. The catalytic performance of the synthesized catalysts was tested in MTO reactions with different time-on-stream. All the samples showed high activity and selectivity to light olefins at the initial stage of the reaction. The maximum yield of ethylene, propylene and butene was determined to be 12.57, 13.45 and 2.21 wt%, respectively. The catalyst produced by the tetraethylammonium hydroxide/morpholine ratio of 1:1 exhibited the longest catalyst lifetime.
23 citations