Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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23 citations
TL;DR: The antitumor activity of o-carboxybenzoylferrocene sodium salt (1) was studied in vivo as mentioned in this paper, and the structure of compound 5 was established by X-ray analysis.
Abstract: The antitumor activity of o-carboxybenzoylferrocene sodium salt (1) was studied in vivo. Interaction between o-carboxybenzoylferrocene (2) and N,N′-carbonyldiimidazole in boiling methylene dichloride leads to 3-(N-imidazolyl)-3-ferrocenylisobenzofuran-1(3H)-one (5). The structure of compound 5 was established by X-ray analysis. Aminolysis of compound 5 in toluene gave rise to ferrocenoylbenzamides (6a–d)–derivatives of dimethylamine, piperidine, pyrrolidine and morpholine. Copyright © 2008 John Wiley & Sons, Ltd.
23 citations
TL;DR: In this article, an efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100°C, is described.
Abstract: In this work, efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100 °C, is described. The key advantages of the present method are short reaction time, high yields, aqueous work-up procedure, low cost, stable, reusable catalyst, and solvent-free reaction conditions.
23 citations
TL;DR: A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
23 citations
TL;DR: In this paper, the authors investigated the condensation reactions of tetrachloro mono (1 and 2) and bisferrocenyl spirocyclotriphosphazenes with morpholine in tetrahydrofuran gave the partly morpholino-substituted finetexted ferroceneylphosphzenes.
Abstract: The condensation reactions of tetrachloro mono (1 and 2) and bisferrocenyl spirocyclotriphosphazenes (3–5) with morpholine in tetrahydrofuran gave the partly morpholino-substituted ferrocenylphosphazenes When the reactions were carried out with equal amounts of 1–5 and morpholine, the mono-substituted ferrocenylphosphazenes (1a, 3a–5a) formed as the major product While the reactions were made with 1 equiv of 1–5 and 2 equiv of morpholine, the corresponding geminal–phosphazenes (1b–5b) were isolated In addition, the condensation reactions of 1 equiv of 1–5 and 3 equiv of morpholine resulted in the formation of di-(1b–5b), tri-(2c–5c), and tetra-substituted phosphazenes The tri-substituted compounds were isolated as major products Some new phosphazenes have stereogenic P center(s) The stereogenic properties of 1a and 2c were investigated using 31P nuclear magnetic resonance (NMR) spectroscopy in the presence of the chiral solvating agent; (S)-(+)-2,2,2-trifluoro-1-(9′-anthryl)ethanol The structures of all the phosphazenes were characterized by one-dimensional 1H, 13C, and 31P NMR, and two-dimensional heteronuclear single quantum coherence spectral data The salient spectral properties of the phosphazenes were presented
23 citations