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Morpholine

About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.


Papers
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Journal ArticleDOI
TL;DR: The kinetics of the reactions of 2-chloro-3-nitropyridine and 5-nitro (para-like) isomer with morpholine and piperidine were studied in methanol and benzene at several amine concentrations and temperatures in the range 25-45°C as mentioned in this paper.
Abstract: The kinetics of the reactions of 2-chloro-3-nitropyridine (ortho-like) and 5-nitro (para-like) isomer with morpholine and piperidine were studied in methanol and benzene at several amine concentrations and temperatures in the range 25–45°C. The data show that k/k ratios are less than unity in methanol. The steric hindrance in the transition state of the 3-nitro (ortho-like) isomer retards o-substitution while the stability of p-quinonoid structure of the 5-nitro (para-like) isomer favors p-substitution. In benzene, the k3-NO2/k5-NO2 ratios are greater than unity. The hydrogen bonding formation between the ammonium hydrogen and the ortho-nitro group in the transition state of 3-nitro isomer favors the o-substitution. © 1997 John Wiley & Sons, Inc.

21 citations

Journal Article
01 Jun 1996-Farmaco
TL;DR: In this article, a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxiacetyl hydrazines were treated with morpholine and formaldehyde.
Abstract: In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2- indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.

21 citations

Journal ArticleDOI
TL;DR: These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile was found to be the most potent against AChE with IC50 4.16 μmol/L.

21 citations

Journal ArticleDOI
TL;DR: Cyclic ethers with 5- to 7-membered rings are formed by sulphenoetherification of unsaturated alcohols with N-(phenylthio)morpholine and trifluoromethanesulphonic acid.
Abstract: Cyclic ethers with 5- to 7-membered rings are formed by sulphenoetherification of unsaturated alcohols with N-(phenylthio)morpholine and trifluoromethanesulphonic acid.

21 citations

Journal ArticleDOI
TL;DR: The reaction of morpholine enamines derived from α-pyridyl ketones with aromatic aldehydes leads to the formation of a 1,5-diketone intermediate which in turn provides a 4′-substituted derivative of 2,2′; 6′,2″-terpyridine as mentioned in this paper.

21 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202385
2022177
202191
2020135
2019129
2018143