Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: In this article, a totally stereoselective formation of heterocycle 6 gives access to a chiral masked form of glyoxal in which the symmetry features of the dialdehyde have disappeared.
20 citations
TL;DR: A simple and selective gas chromatographic method was established for determining naturally occurring secondary amines as mentioned in this paper, which was carried out with a capillary coated with OV-101 and a flame photometric detector.
Abstract: A simple and selective gas chromatographic method was established for determining naturally occurring secondary amines. Secondary amines separated from foods by extraction with dichloro-methane and reextraction with hydrochloric acid were readily converted into the corresponding sulfonamides by reaction with benzenesulfonyl chloride under alkaline condition. Gas chromatography was carried out with a capillary coated with OV-101 and a flame photometric detector. Column temperature was programmed from 170 to 230°C at a rate of 5°C/min.The obtained sulfonamides were separated from one another within 40 min.Eleven secondary amines examined were added to 5 kinds of foods and recovered from them. The mean recovery rates were in the range 71.3% (dimethylamine)–99.8% (piperidine).The limits of detection varied from 0.002 ppm (dimethylamine) to 0.01 ppm (morpholine).
20 citations
TL;DR: In this article, facile syntheses of 1,2 and 3,5-cyclic sulfite and sulfate furanoside diesters were conducted in molecular solvents and ionic liquids in the presence of immobilised morpholine.
20 citations
TL;DR: Kinetic studies of the ROP reveal that the molar masses and dispersities could be well controlled, and Matrix-assisted laser desorption time-of-flight mass spectrometry indicates the presence of polymer chains with α-end groups derived from the initiator.
Abstract: In a two-step synthesis, five different alkyl-substituted morpholine-2,5-dione monomers were synthesized from the natural amino acids glycine, alanine, valine, leucine, and isoleucine. The heterocyclic compounds crystallize in a boat-like conformation and are polymerized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-catalyzed ring-opening polymerization (ROP) in tetrahydrofuran. Well-defined polymers could be obtained from the monomers based on valine, leucine, and isoleucine at a feed ratio of M/I/TBD = 100/1/0.5. Kinetic studies of the ROP reveal that the molar masses and dispersities (Đ < 1.2) could be well controlled, as confirmed by size exclusion chromatography and 1 H NMR spectroscopy. At conversions above 50%, the polymerization rate decreases and the dispersity slightly increases, presumably due to transesterification. Matrix-assisted laser desorption time-of-flight mass spectrometry indicates the presence of polymer chains with α-end groups derived from the initiator.
20 citations
TL;DR: In this paper, N-substituted nitrodiene 3a was obtained from the reaction of la with p-phenylendiamine and benzidine gave the compounds 5a-b.
Abstract: Mono(thio)substituted nitrodienes 1a-b give the compounds 7a and 7b cohen treated with piperazine. S, N-substituted nitrodiene 3a was obtained from the reaction of la with p-phenylendiamine. Under the same conditions the compounds la-b and benzidine give the compounds 5a-b. The compounds la-b from the reaction with aniline in ether yielded 9s-b. Mono(thio)substituted nitrodienes la-b give 11a-b by the reaction with piperidine in ether. 13a-c are prepared by the reaction of compounds la-c with morpholine.
20 citations