Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: Experiments with N-methylaniline and morpholine have shown that thiocyanate, a normal constituent of human saliva, has a pronounced catalytic effect on the reaction between nitrite and secondary amines to form nitrosamines.
80 citations
TL;DR: A facile and effective fluoride post-treated route has been systematically applied for the preparation of hierarchical zeolite catalysts in three different SAPO-34 systems using morpholine, triethylamine and tetraethylammonium hydroxide as template, respectively.
80 citations
TL;DR: A 3D-QSAR analysis using the GRID/GOLPE methodology was performed to get a better understanding of the relationship between chemical structure and biological activity, and found that the size of the morpholine or 1,4-oxazepane ring seems to be important for affinity.
Abstract: Since the identification of the dopamine D4 receptor subtype and speculations about its possible involvement in schizophrenia, much work has been put into development of selective D4 ligands. These selective ligands may be effective antipsychotics without extrapyramidal side effects. This work describes the synthesis of a new series of 2,4-disubstituted morpholines and 2,4-disubstituted 1,4-oxazepanes with selectivity for the dopamine D4 receptor. A 3D-QSAR analysis using the GRID/GOLPE methodology was performed with the purpose to get a better understanding of the relationship between chemical structure and biological activity. Inspection of the coefficient plots allowed us to identify that regions which are important for affinity are situated around the two benzene ring systems, a p-chlorobenzyl group, and the aliphatic amine belonging to the morpholine or 1,4-oxazepane system. In addition, the size of the morpholine or 1,4-oxazepane ring seems to be important for affinity.
79 citations
Patent•
08 Jan 1979
TL;DR: Substituted morpholine derivatives, such as, for instance, the compound 2-[α-(2-methoxy-phenoxy)-benzyl]-morpholine are disclosed.
Abstract: Substituted morpholine derivatives, such as, for instance, the compound 2-[α-(2-methoxy-phenoxy)-benzyl]-morpholine are disclosed. The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.
78 citations
TL;DR: Reductive alkylation under neutral to mild acid conditions allows modification of alkaline labile proteins and also limits the side reactions between proteins and formaldehyde.
77 citations