Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: This study suggests the possibility of functionalizing morpholine-containing beta-turn peptides with no significant loss of the secondary framework.
Abstract: Four peptides differing for the structure of the new morpholine-based heterocyclic compound acting as a turn inducer were synthesized in solution phase, and the conformational preferences were assessed by means of NMR analysis. All spectroscopic data revealed an adaptive behaviour of the turn peptides in generating turn conformations stabilized by intramolecular hydrogen-bonds, despite the conformational changes of the turn inducer. Thus, this study suggests the possibility of functionalizing morpholine-containing β-turn peptides with no significant loss of the secondary framework. The 3,4-dihydro-2H-[1,4]oxazine-containing peptide showed a more compact structure stabilized by an additional γ-turn-forming hydrogen-bond experienced by the Gly amide proton.
19 citations
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TL;DR: Some novel [1,2,4]triazolo[3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (ABG) compounds were prepared by heating 4-amino-5-aryl-1, 2, 4-triazole-3-thiones with different carboxylic acids in POCl3 as mentioned in this paper.
Abstract: Some novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazolylisoindole-1,3-dione 2a–c were prepared by heating 4-amino-5-aryl-1,2,4-triazole-3-thiones 1a–c with different (1,3-dioxo-1,3-dihydro-isoindol-2-yl) carboxylic acids in POCl3. Compounds 2a, b were hydrolyzed using HCl to yield [1,2,4]triazolo[3,4-b][1,3,4]thiadiazolyl-alkylamines 3a, b. Coupling 1a, c with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (ABG) afforded the corresponding S-glucosides 4a, b, which on oxidation with KMnO4 gave the corresponding sulfone 5. Treatment 1b, c with diphenyl diazomethane afforded benzhydrylsulfanyltriazolylamines 7a, b. 1,8-Bis-(4-chloro-phenyl)-bis[1,2,4]triazolo[3,4-c-,4′,3′-e][1,2,4,5]dithiadiazine 8 was formed by oxidation of 1b with lead tetracetate. Compound 1c reacted with morpholine in the presence of KI and I2 to give the triazolodisulfide 9 .
19 citations
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TL;DR: In this article, an efficient synthesis of 2,4-diary lyrroles was described, using a mixture of a 4-nitro-1,3-Diarylbutan-1-one and ammonium acetate in the presence of morpholine and sulfur.
Abstract: An efficient synthesis of 2,4-diarylpyrroles is described. Heating a mixture of a 4-nitro-1,3-diarylbutan-1-one and ammonium acetate in the presence of morpholine and sulfur afforded the corresponding 2,4-diarylpyrroles in excellent yields.
19 citations
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TL;DR: In this paper, the spectral and photochromic properties of spironaphthooxazines (SNOs) with piperidine and morpholine substituents have been studied at different temperatures in various solvents.
Abstract: Spectral and photochromic properties of spironaphthooxazines (SNOs) with piperidine and morpholine substituents have been studied at different temperatures in various solvents. It has been recognized that introduction of these substituents in naphthooxazine fragment leads to fluorescence of the initial form of SNO molecules at low temperatures, which disappears with temperature rise. The dependences of the photoinduced form in non-polar solvents. It is proposed that the coloured form of substituted SNOs has a bipolar structure with a positive charge on piperidine or morpholine nitrogen atom contrary to the quinonoic form of unsubstituted SNO.
19 citations
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TL;DR: Regioselective routes are described for convenient preparation of novel piperazine/morpholine substituted quinoline derivatives that have the potential of drug candidates to treat of some diseases including glaucoma, epilepsy, Alzheimer’s disease (AD), leukemia, and type-2 diabetes mellitus (T2DM).
19 citations