Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: The synthesis and structure-activity relationship of a series of chiral alkoxymethyl morpholine analogs are reported, leading to the identification of (S)-2-(((6-chloropyridin-2-yl)oxy)methyl)-4-((6-fluoro-1H-indol-3-yl(yl)methyl)morpholine as a novel potent and selective dopamine D4 receptor antagonist with selectivity against the other dopamine receptors tested.
18 citations
TL;DR: In this paper, a trans-4, 4, 4′-Dibromostilbene (trans-4.4′) was used for cycloaddition of six-membered heterocycles.
Abstract: trans-4,4′-Dibromostilbene
R 4-Bromoaniline; Vinyltriethoxysilane
I 4-[(Bromophenyl)azo]morpholine
P trans-4,4′-Dibromostilbene
Keywords:
heterocycles, six-membered, one nitrogen, one oxygen;
azo compounds;
halogen compounds, bromine compounds;
esters;
coupling;
diazotization, cycloaddition;
metal-catalyzed reactions (exclusive of reductions), palladium;
1-aryl triazenes, toxic, irritants
18 citations
TL;DR: In this paper, two cyclotetraphosphazene derivatives were synthesized by the reaction of octachlorocyclotetraprapazene with the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride.
Abstract: Two novel cyclotetraphosphazene derivatives were synthesized by the reaction of octachlorocyclotetraphosphazene with the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride. The bromination reaction was carried out using PBr3 to give N4P4(OC6H4-p-CH2Br)8 (4). This compound was employed in reaction with imidazole or morpholine to produce eight-armed, star-branched title compounds. The target compounds were characterized by 1H, 31P, and 13C NMR as well as IR and ESI-MS. The Cu complex of 5a was effective in oxidative cleavage reactions. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT
18 citations
18 citations
TL;DR: In this article, intermediate intermediates involved in the conversion of 3-alkyl-3,4-dihydro-2H-1,3-benz[e]oxazines into 2-N,N-dialkylaminomethylphenol derivatives, using morpholine and other high boiling secondary amines, have been identified and characterised.
18 citations