Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: The Mannich-bases were also obtained by reaction of the appropriate amines with the corresponding chloromethyl- (If), or hydroxymethylphthalazinone derivatives (Ie).
18 citations
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TL;DR: The metabolic conversions of C 14 - and P 32 -labeled OPSPA into morpholine, MEPA, and inorganic phosphate have been demonstrated by carrier crystallization and chromatographic procedures.
Abstract: Summary 1.The metabolic conversions of C 14 - and P 32 -labeled OPSPA into morpholine, MEPA, and inorganic phosphate have been demonstrated by carrier crystallization and chromatographic procedures. 2.In rats the primary metabolite was MEPA, little unchanged OPSPA was found, and there was cleavage to morpholine and inorganic phosphate. 3.In humans considerable MEPA was produced, but there was a greater quantity of unidentified metabolites. There was more production of inorganic phosphate than of morpholine in humans.
18 citations
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TL;DR: The two carbon-centered radicals 4-morpholinomethyl ( 4 ) and 4-methylmorpholin-3-yl ( 5 ), generated from the primary cation radical intermediate 3 by β-deprotonation, are the major radical species in reaction mixtures of N -methylmorpholine- N -oxide ( 1 ) as demonstrated by trapping reactions with γ-tocopherol as discussed by the authors.
18 citations
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TL;DR: In this paper, a novel, stereoselective synthesis of the enantiomer of alcohol 5 is disclosed. The key steps of the synthesis include mercuric trifluoroacetate promoted regio-and stereose-lective hydration of an α,β-unsaturated ester, Frater-alkylation and use of morpholine derived amide for acylation.
18 citations
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TL;DR: In this paper, the 1:1 complex of N -methylmorpholine betaine (MMB) with 4-hydroxybenzoic acid (4-HBA) has been determined by X-ray diffraction.
18 citations