Morpholine

About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.

Hydroaminomethylation in thermomorphic solvent systems

Abstract: The rhodium catalyzed hydroaminomethylation of 1-octene with morpholine has been studied using temperature-dependent solvent systems (TMS systems). High conversions of the olefin and high selectivities to the amines are obtained in TMS systems consisting of propylene carbonate, an alkane and a semi-polar mediator, although some morpholine reacts with propylene carbonate in a side reaction. With N-octylpyrrolidone as mediator the conversion of 1-octene and the selectivity of the corresponding amines reached in each time 92%. After the reaction the catalyst can be easily recovered by a simple phase separation with only a negligible loss of the rhodium catalyst.

Ring-opening of gamma-valerolactone with amino compounds

Abstract: Diols obtained by the ring-opening of biomass-based gamma-valerolactone (GVL) are potentially valuable building blocks that can be used as precursors in the manufacture of green polymers and resins. We report here a study on the ring-opening of GVL through adding amine compounds. The reactivity of the applied amine compounds in this ring-opening was tested by varying the structure of the amine compounds. Both mono-amines (ammonium, 2-aminoethanol, 2-phenylethylamine, and morpholine) and di-amines (1,2-diaminoethane, 1,2-diaminopropane, and piperazine) were used. The study showed that steric hindrance at the reacting amine-function plays a more prominent role than local point charge. To optimize the yield of the desired di-functional monomers, the ring-opening of GVL with 1,2-diaminoethane (1,2-DE) was studied in more detail. Reaction temperature (25-100 degrees C), reaction time, and molar ratio of the reactants appeared to be the determining processing parameters. These were found to be more important than the use of catalysts (triphenylphosphine, Tin(II)-2-ethylhexanoate, Ytterbium(III)trifuoromethanesulfonate, AlCl3, and SnCl2) and solvent polarity (methanol, DMA, DMSO, and water). (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 3556-3564, 2012

Synthesis of new 1,2,4-triazole compounds containing Schiff and Mannich bases (morpholine) with antioxidant and antimicrobial activities.

Abstract: Compound 2 was synthesized by reacting CS2/KOH with compound 1. The treatment of compound 2 with hydrazine hydrate produced compound 3. Then, compound 3 was converted to Schiff bases (4a–d) by the handling with several aromatic aldehydes. The treatment of triazole compounds 4a–d containing Schiff base with morpholine gave compounds 5a–d. All compounds were tested for their antioxidant and antimicrobial activities. The antioxidant test results of DPPH• radical scavenging and ferric reducing/antioxidant power methods showed good antioxidant activity. The triazole-thiol (3) was the most active, and the effect of the substituent type of the thiophene ring on the activity was same for both Schiff bases (4a–d) and Mannich bases (5a–d). Among the newly synthesized triazole derivatives, the Schiff base 4d and the Mannich base 5d carrying nitro substituent on the thiophene ring showed promising antibacterial and antifungal activity, with lower MIC values than the standard antibacterial ampicillin.