Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
Papers published on a yearly basis
Papers
More filters
TL;DR: In this article, the XRD structures of complexes 1, 3 and 5 are reported, where the heterocyclic ligands occupy equatorial coordination sites and the mononuclear compound 5 consists of three CO groups, two N coordinated η 1 -1-methylimidazole ligands and a terminal Cl ligand.
17 citations
TL;DR: Comparisons are presented which establish that the two metabolites whose structures were previously in question are identical with their synthetic counterparts 2 and 3, and which indicate that only 4, in which the morpholine moiety has been degraded to a 2-hydroxyethylamino group, had significant beta-adrenergic blocking activity.
Abstract: Syntheses are reported for three metabolites (2-4) of timolol (1) formed by oxidative metabolism of the morpholine ring. GLC-MS comparisons are presented which establish that the two metabolites whose structures were previously in question are identical with their synthetic counterparts 2 and 3. In 2, metabolic oxidation of the 4-morpholinyl group of 1 had occurred at the carbon next to oxygen to give the 2-hydroxy-4-morpholinyl moiety, whereas in 3, the morpholine of 1 has been oxidized one step further and then ring opened to produce the N-(2-hydroxyethyl)glycine substituent. Biological testing of synthetic samples of the three major metabolites from human urine (3, 4, and 6) indicated that only 4, in which the morpholine moiety has been degraded to a 2-hydroxyethylamino group, had significant beta-adrenergic blocking activity (one-seventh that of timolol in anesthetized dogs).
17 citations
TL;DR: A series of new 1,2,3-triazolyl methyl ester of morpholine-3-carboxylic acid analogues were designed and synthesized employing click chemistry by using Huisgen 1,3 dipolar cyclo addition reaction between propargyl ester and aryl azides as mentioned in this paper.
Abstract: A series of new 1,2,3-triazolyl methyl ester of morpholine-3-carboxylic acid analogues were designed and synthesized employing click chemistry by using Huisgen 1,3 dipolar cyclo addition reaction between propargyl ester of morpholine-3-carboxylic acid and aryl azides. The starting materials propargyl ester and aryl azides were synthesized by well established methods. The newly synthesized compounds were characterized by spectral studies. The compounds were screened for antibacterial activity. Majority of the compounds exhibited promising activity and one of them (6i) displayed more activity than standard drug against S. paratyphi-B. A molecular docking study showed hydrogen bonds and pi-interactions with the compound. Our data indicate that these derivatives may present promising anti-bacterial agents.
17 citations
TL;DR: In this paper, a dry gel method was used to synthesize small particles of less than 500nm within a short reaction time of 30 min, which were characterized by X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive Xray spectroscopy, and gas sorption analysis.
17 citations
TL;DR: Purolite's weakly basic experimental resins with diethanolamine, morpholine, 2-vinylpyridine, mono and bispicolylamine functionalities were evaluated with respect to their hydrogen, Zn, Ni, Cu and Cd uptake, and compared with commercial chelating iminodiacetate, aminophosphonate and hydroxamic acid resins as discussed by the authors.
Abstract: Purolite's weakly basic experimental resins with diethanolamine, morpholine, 2-vinylpyridine, mono-and bispicolylamine functionalities were evaluated with respect to their hydrogen, Zn, Ni, Cu and Cd uptake, and compared with Purolite's commercial chelating iminodiacetate, aminophosphonate and hydroxamic acid resins. Special attention was paid to the resin performances in acidic solutions. In general, diethanolamine, morpholine and 2-vinylpyridine resins took up these metals poorly. Only cadmium was retained in acidic solutions, probably as negatively charged chloride complexes. The chelating resins, with their weakly acidic groups, did not function in acidic solutions but worked well at pH 4 and above. The only resin that efficiently removed metals from acidic solutions was the bispicolylamine resin. Metal uptake values on this resin did not change appreciably in the pH range between 1 and 6. Maximum uptake values ranged between 0.6 and 1.7 mmol/g, being highest for copper and lowest for nickel. Acid/bas...
17 citations