Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: In this article, the authors investigated the effect of ozone at the carbon-hydrogen bond of a methylene group of the morpholine ring and showed that the reaction occurs through the insertion of ozone.
16 citations
TL;DR: In this article, the kinetics of the reactions of (CO)5CrC(SMe)Ph (4-Cr) with five primary aliphatic and four secondary alicyclic amines have been investigated in 50% MeCN−50% water (v/v) at 25 °C.
16 citations
Patent•
19 Feb 1969
TL;DR: In this article, Bedrijven et al. presented pyrimidine derivatives of formula in which R 1 is a hydrogen atom or a C 1-5 alkyl group, R 2 is a halogen atom, R 3 is an aralkyl group, and R 4 is a C 2-5 group which is substituted by one or more hydroxy groups, each hydroxy group being separated from the nitrogen atom.
Abstract: 1,143,167. Pyrimidine derivatives. UCB (UNION CHIMIQUE-CHEMISCHE BEDRIJVEN) S.A. 24 Jan., 1968 [25 Jan., 1967], No. 3774/67. Heading C2C. Novel pyrimidine derivatives of formula in which R 1 is a hydrogen atom or a C 1-5 alkyl group, R 2 is a hydrogen or halogen atom or a C 1-5 alkyl, hydroxyalkylamino, #-aryl- #-hydroxyalkylamino or morpholino group, R 3 is a hydrogen atom, a C 1-5 alkyl group which may be substituted by one or more hydroxy groups, or an aralkyl group, R 4 is a C 2-5 alkyl group which is substituted by one or more hydroxy groups, each hydroxy group being separated from the nitrogen atom to which the alkyl group is attached by at least two carbon atoms, or R 3 and R 4 , together with the nitrogen atom to which they are attached, represent a morpholino group, and their acid addition salts, are prepared (a) when R 2 is a hydrogen atom or an alkyl radical, by reacting a 2-R 1 -6-halo-pyrimi. dine or 2 - R 1 - 4 - alkyl - 6 - halo - pyrimidine with a primary or secondary hydroxylamine or with morpholine, or (b) when R 2 is a halogen atom or a hydroxyalkylamino or morpholino group, by reacting a 2-R1-4,6-dihalo-pyrimidine with a primary or secondary hydroxyalkylamine or with morpholine under such conditions and in such an amount that a 2-R 1 -4-halo-6- hydroxyalkylamino - pyrimidine, 2 - R 1 - 4 - halo - 6 - morpholino - pyrimidine, 2 - R 1 - 4,6- bis - hydroxyalkylamino - pyrimidine or 2-R 1 - 4,6 - dimorpholino - pyrimidine is obtained, or (c), when R 2 is a hydroxyalkylamino, #-aryl-#- hydroxyalkylamino or morpholino group, by reacting a 2-R 1 -4-halo-6-hydroxyalkylaminopyrimidine or 2-R 1 -4-halo-6-morpholino-pyrimidine with a primary hydroxyalkylamine or #- aryl-#-hydroxyalkylamine or morpholine and, if desired, converting a resulting base into an acid addition salt. Pharmaceutical compositions having hypotensive, vasodilatory, diuretic, bronchodilatory, spasmolytic and analeptic properties, comprise one of the novel compounds together with a carrier.
16 citations
TL;DR: In this paper, a new morpholine-based ligand was prepared from condensation of a branched amine containing morpholine, N1-(3-morpholinopropyl)-N1-((pyridine-2-yl)methyl)ethane-1,2-diamine (1), and salicylaldehyde.
16 citations
TL;DR: The neutral complexes In2X4•2L (X = Cl, Br, I; L = 1,4-dioxan, tetrahedron, tetrahydropyran, trichloroethyl sulfoxide) and In2x4•4L(X = Br,I, I, L = piperidine, piperazine, morpholine) have been prepared as discussed by the authors.
Abstract: The neutral complexes In2X4•2L (X = Cl, Br, I; L = 1,4-dioxan, tetrahydropyran, tetrahydrofuran, tetrahydrothiophene), In2X4•2L (X = Br, I; L = dimethylsulphide), In2X4•4L (X = Cl, Br, I; L = piperidine, piperazine, morpholine), and In2X4•4L (X = Br, I; L = pyridine, dimethylsulphoxide) have been prepared. Solid state Raman spectra indicate that the compounds contain indium–indium bonds.
16 citations