Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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Patent•
27 Aug 1976TL;DR: In the extractive distillation of C 5 hydrocarbons with different degrees of unsaturated using acetonitrile, an increase in the selectivity was obtained when also using with acetitrile small amounts of at least one compound selected from the group consisting of dimethylformamide, dimethylsulfoxide, morpholine, furfural, N-methylpyrrolidone, 3methoxypropionitrile and gamma-butyrolactone as discussed by the authors.
Abstract: In the extractive distillation of C 5 hydrocarbons with different degrees of unsaturated using acetonitrile, an increase in the selectivity of acetonitrile is obtained when also using with acetonitrile small amounts of at least one compound selected from the group consisting of dimethylformamide, dimethylsulfoxide, morpholine, furfural, N-methylpyrrolidone, 3-methoxypropionitrile, gamma-butyrolactone, ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and diethylene glycol monoethyl ether.
16 citations
Patent•
23 Feb 1988TL;DR: In this paper, an osmium-catalyzed method of addition to an olefin was presented, where a chiral ligand, an organic solvent, water, and an amine derivative were combined.
Abstract: An osmium-catalyzed method of addition to an olefin. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, and aamine oxide and an osmium-containing compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, an amine derivative and an osmium-containing compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative or an amine derivative and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, N-methyl morpholine N-oxide and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.
16 citations
01 Jan 1989-International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
TL;DR: The 99mTc-BAT complexes prepared by the tin-reduction method proved to be stable under in vitro conditions and the brain uptake values in CD-1 mice were comparably low.
16 citations
TL;DR: In this paper, the authors proposed a novel complexes M(CO)5S(NR2)2 (M = Cr, Mo or W) by the addition of N,N′-thiobisamine (NR2 = dimethylamine, piperidine, morpholine or dibenzylamine) to UV-irradiated tetrahydrofuran solutions of M( CO)6.
16 citations
TL;DR: The in vitro metabolism of AM-630 was studied by high-performance liquid chromatography coupled with tandem mass spectrometry and found that it behaves primarily as a potent CB2-selective antagonist.
Abstract: The in vitro metabolism of AM-630 was studied by high-performance liquid chromatography coupled with tandem mass spectrometry. AM-630 is an aminoalkylindole analogue that behaves primarily as a potent CB2-selective antagonist. In this study, 17 metabolic products were identified that resulted from the incubation of AM-630 in rat liver microsome preparations. Six metabolic pathways were proposed to account for all detected metabolites: (1) o-demethylation of the methoxyphenyl group, (2) morpholinyl ring opening, (3) hydroxylation on the methoxy/hydroxyl phenyl ring, (4) hydroxylation on the indole ring, (5) hydroxylation on the morpholine ring and (6) loss of the morpholine ring leading to metabolites containing either a hydroxylated or a carboxylated alkyl terminal. Three metabolites were identified as morpholinyl ring-opening products: M1, M6 and M13. Six metabolites (M2-M5, M7 and M8) were proposed to be the products of o-demethylation, hydroxylation on the methoxyphenyl group or the morpholinyl ring, dehydration following morpholinyl ring monohydroxylation, or a combination of the above metabolic pathways. The remaining eight metabolites were attributed to a pathway involving the loss of the morpholine ring at various points during the metabolic processes.
16 citations