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Morpholine

About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.


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Journal ArticleDOI
TL;DR: In this paper, the HRh(CO)(PPh 3 ) 3 complex was encapsulated into the pores of amino functionalized hexagonal mesoporous silica and was characterized by physico-chemical techniques like P-XRD, 31 P-CPMAS NMR, FT-IR, SEM, ICP and N 2 adsorption analysis.
Abstract: HRh(CO)(PPh 3 ) 3 complex was encapsulated into the pores of amino functionalized hexagonal mesoporous silica. The catalyst was characterized by physico-chemical techniques like P-XRD, 31 P-CPMAS NMR, FT-IR, SEM, ICP and N 2 adsorption analysis. The catalyst was active for hydroaminomethylation and a variety of alkenes and amines were used as reactants for hydroaminomethylation. The catalyst afforded to achieve 100% conversion with high (>95%) selectivity to corresponding amines. Parametric variations were performed by taking 1-hexene and morpholine as representative reactants for the study of catalyst amount, temperature, pressure and 1-hexene:morpholine ratio. Significant amounts of aldehydes and enamines were observed during the course of the reaction indicating that there could be two possible rate determining steps. The catalyst was effectively recycled up to five times without much loss in its activity and selectivity.

16 citations

Journal ArticleDOI
TL;DR: Thiazole hybrids 9d and 9e, attached to two chromene units at thiazole-C2 and C4, and linked to methyl or methoxy groups, respectively, showed the best antibacterial activity and gave the best bacterial biofilm inhibitory activity against S. aureus, S. mutans and E. coli strains.

16 citations

Journal ArticleDOI
TL;DR: The bis acetato and propionatometal adducts of piperidine (pipd), piperazine, pipz, N-methylpiperazine (CH3-pipz), and morpholine (morpholine) are isolated in the solid state and investigated by spectral and magnetic measurements.
Abstract: Die bis-Acetato- und Propionato-Metalladdukte von Piperidin-(pipd), Piperazin(pipz), N-Methylpiperazin(CH3-pipz) und Morpholin(morph) wurden in festem Zustande isoliert und optisch und magnetisch untersucht. Piperazin bildet 1:1-Komplexe, die anderen Amine bilden 1:2-Komplexe. Die IR-Spektren ergeben, das die Amine an das Metallatom uber das N-Atom koordiniert sind, Acetat und Propionat sind symmetrische oder asymmetrische zweizahnige Liganden. In Monopiperazin-Addukten verbruckt das Amin zwei Metallatome. Elektronenspektren und magnetische Momente weisen auf eine transoktaedrische Konfiguration der Addukte. Acetato- und Propionato-Komplexe gesattigter N-Heterozyclen mit CoII, NiII und CuII The bis acetato and propionatometal-adducts of piperidine (pipd), piperazine (pipz), N-methylpiperazine (CH3-pipz) and morpholine (morph) are isolated in the solid state and investigated by spectral and magnetic measurements. Piperazine forms 1:1 complexes, the other amines 1:2 complexes. The infrared spectra show that the amines are coordinated to the metal atom toward the nitrogen atom and that the acetate and propionate act as symmetrical or asymmetrical bidentate ligands. The i.r. spectra give also evidence that in monopiperazine adducts the amine “bridges” two metal atoms. Electronic spectra and magnetic moments suggest a tran-octahedral configuration of the adducts.

16 citations

Journal ArticleDOI
TL;DR: Three different pincer ligand systems are synthesized via nucleophilic substitution reactions of polyaromatic benzyl bromides as support molecules and phenol derivatives as ligand precursors and show high selectivity towards the linear trans products.
Abstract: Three different pincer ligand systems are synthesized via nucleophilic substitution reactions of polyaromatic benzyl bromides as support molecules and phenol derivatives as ligand precursors. Retention tests using a polymeric nanofiltration membrane show moderate to good retention in THF and CH2Cl2. Concentration-dependent NMR spectroscopy gives no indication for the formation of aggregates in solution. The three ligand systems are active in both the allylic alkylation and allylic amination reactions and show high selectivity towards the linear trans products. An investigation of the kinetic parameters of the allylic amination reaction show that the reaction of cinnamyl acetate with morpholine is of zero order in cinnamyl acetate and of first order in morpholine. The order in catalyst is found to be one, and the rate constant k’ is determined for a reaction under standard conditions. Moreover, one of the tri- ACHTUNGTRENUNG(pincer)-palladium complexes is used as soluble, molecularweight- enlarged homogeneous catalyst in continuous allylic alkylation and amination reactions. The conversion of the allylic alkylation reaches a maximum of 30%, while a maximum conversion of 80% is reached in the allylic amination reaction. No palladium black was formed.

16 citations

Journal ArticleDOI
TL;DR: Arguments are presented showing that the deuterium isotope effects on 13C chemical shifts originate in electric field effects.
Abstract: A series of intramolecularly hydrogen-bonded N-substituted 3-(piperidine, morpholine, N-methylpiperazine)thiopropionamides and some corresponding amides have been studied with special emphasis on hydrogen bonding. The compounds have been selected in order to vary and to minimize the N...N distance. Geometries, charge distributions, and chemical shifts of these compounds are obtained from DFT-type BP3LYP calculations. 1H and 13C 1D and 2D NMR experiments were performed to obtain H,H coupling constants, 13C chemical shifts assignments, and deuterium isotope effects on13C chemical shifts. Variable-temperature NMR studies and 2D exchange NMR spectra have been used to describe the rather complicated conformational behavior mainly governed by the ring flipping of the piperidine (morpholine) rings and intramolecular hydrogen bonding. Unusual long-range deuterium isotope effects on 13C chemical shifts are observed over as far as eight bonds away from the site of deuteriation. The isotope effects are related to the N...N distances, thus being related to the hydrogen bonding and polarization of the N-H bond. Arguments are presented showing that the deuterium isotope effects on 13C chemical shifts originate in electric field effects.

16 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202385
2022177
202191
2020135
2019129
2018143