Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: The enaminones 1b,d,f react with 4-phenyl-3-methyl-5-pyrazoleamine 3a to yield the pyrazole derivatives 4a-c that cyclised readily on reflux in pyridine solution in presence of hydrochloric acid as mentioned in this paper.
43 citations
TL;DR: Good fungicidal results were obtained against the various types of fungi under investigation and the target compounds showed good inhibition towards Gram +ve bacteria, Gram -ve bacteria and yeast.
42 citations
TL;DR: An efficient new method is reported for the chemical synthesis ofcyl glucuronides by selective 1beta-acylation of allyl glucuronate with carboxylic acids catalyzed by HATU and then mild deprotection through treatment with Pd(PPh(3))(4) and morpholine.
42 citations
TL;DR: A new series of 3-alkyl-, 3-trifluoromethyl, 3-carboxyethyl- and 3-bromomethYLquinoxaline-2-ones and 2,3-bis(bromometrichyl)quinoxalines bearing Cl, CF3, morpholine on the benzo-moiety were synthesised and submitted to a preliminary in vitro evaluation for antibacterial and anticandida activities.
Abstract: A new series of 3-alkyl-, 3-trifluoromethyl-, 3-carboxyethyl- and 3-bromomethylquinoxaline-2-ones and 2,3-bis(bromomethyl)quinoxalines bearing Cl, CF3, morpholine on the benzo-moiety, were synthesised and submitted to a preliminary in vitro evaluation for antibacterial and anticandida activities. Results of the screening showed that compounds 9b, 14b and 19b (MIC=62.5 μg/ml) and 10b (MIC=15.6 μg/ml) were the most active against Vibrio alginolyticus.
42 citations
TL;DR: It is suggested that Mannich bases of kojic acid bearing substituted benzyl piperazine groups (compounds 1, 3, 4, 11, 13, 14, 23, 24, 28, and 29) could be promising antityrosinase agents.
42 citations