Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
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TL;DR: Tetradentate salicylaldimine ligands of the H2salen type bearing ortho-N-morpholinomethyl substituents function as ditopic ligands, bonding to NiII or CuII with the [N2O2]2− donor set of the salen unit and a sulfate or two nitrate anions with the protonated morpholine units as mentioned in this paper.
Abstract: Tetradentate salicylaldimine ligands of the H2salen-type bearing ortho-N-morpholinomethyl substituents function as ditopic ligands, bonding to NiII or CuII with the [N2O2]2− donor set of the salen unit and a sulfate or two nitrate anions with the protonated morpholine units. The binding of the metal salt by the zwitterionic form of the ligand provides a novel approach to the transport of metal sulfates in metal recovery processes. A comparison of the solid state structures of a “free” ligand with a series of nickel(II) complexes demonstrates that the metal ion templates the ligand system, orientating the pendant morpholinium groups to form electrostatic and bifurcated hydrogen bonds in the sulfate complex to the dianion creating a neutral 1∶1∶1 [LM2+X2−] complex suitable for extraction into water immiscible solvents. Other binding modes involving bridging of metal complex units by anion binding to the pendant morpholine groups suggest that these ditopic ligands could also be used to assemble unusual three-dimensional arrays of metal complexes in the solid state.
32 citations
TL;DR: The objectives of this study were analysis of the secondary metabolite products and evaluation antibacterial activity of Malva sylvestris and bioactive compounds identified in the methanolic extract.
Abstract: The objectives of this study were analysis of the secondary metabolite products and evaluation antibacterial activity.
Bioactives are chemical compounds often referred to as secondary metabolites. Thirty six bioactive compounds were
identified in the methanolic extract of Malva sylvestris. The identification of bioactive chemical compounds is based on
the peak area, retention time molecular weight and molecular formula. GC-MS analysis of Malva sylvestris revealed the
existence of the1-Propanamine , 2-methyl-N-(2-methylpropyldene)- , Pyrrolidine,1-(1-oxo-2,5-octadecadienyl)- ,
Dimethyl sulfoxide , Cyclohexylamine ,N-ethyl- , N-(2-Methylbutylidene)isobutylamine , 1-Methyl-2-pyrrolideethanol ,
2-(2-Hydroxyethyl)piperidine , 1-Butanamine , 2-methyl-N-(2-methylbutylidene)- , 4-(Pyrrolidin-2-
ylcarbonyl)morpholine , Dithiocarbamate , S-methyl-,N-(2-methyl-3-oxobutyl)- , l-Gala-l-ido-octonic lactone , 1-(5'-
methylfurfuryl)pyrrolidine , 2-Methoxy-4-vinylphenol , Pyrrolizin-1,7-dione-6-carboxylic acid , methyl(ester) , 1-
Naphthaienol , 1,2,3,4-tetrahydro-2,5,8-trimethyl- , Pterin-6-carboxylic acid , N-(2-Acetamido)iminodiacetic acid , N-(1-
Hydroxy-4-oxo-1-phenylperhydroquinolizin-3-yl)carbamic , Cyclopropanedodecanoic acid , 2-octyl-,methyl ester ,
Cholestan-3-ol,2-methylene-,(3?,5?)- , 3-(N,N-Dimethyllaurylammonio)propanesulfonate , Pyrazole[4,5-b]imidazole ,
1-formyl-3-ethyl-6-?-d-ribofuranosyl- , Octahydrobenzo[b]pyran , 4a-acetoxy-5,5,8a-trimethyl- , Tetraacetyl-d-xylonic
nitrile , 4,6-Heptadien-3-one,1,7-diphenyl- , Pentanoic acid ,2,2,4-trimethyl-3-carboxyisopropyl , isobutyl ester , DFructose
, diethyl mercaptal, pentaacetate , Phytol , Hexadecanamide , Tributyl acetylcitrate , Cholestan-3-one,cyclic 1,2-
ethanediyl aetal , (5?)- , Dasycarpidan-1-methanol, acetate ( ester)- , 9-Desoxo-9-x-acetoxy-3,8,12-tri-O-acetylingol ,
(+)-y-Tocopherol, O-methyl- , Campesterol and Stigmasterol.
32 citations
TL;DR: In this article, the Ga2X4 · 2L (L = pyridine, 3-methylpyridine) and Ga2Cl4 4 · 2pyridines have been synthesized.
32 citations
TL;DR: The inclusion of a C-2 trialkylsilyl substituent into allylic amine precursors allows the base-induced aza-[2,3]-Wittig sigmatropic rearrangement to proceed in excellent yield and diastereoselectivity as mentioned in this paper.
Abstract: The inclusion of a C-2 trialkylsilyl substituent into allylic amine precursors allows the base-induced aza-[2,3]-Wittig sigmatropic rearrangement to proceed in excellent yield and diastereoselectivity. The rearrangement precursors require a carbonyl-based nitrogen protecting group that must be stable to the excess of strong base required for the reaction. The N-Boc and N-benzoyl group are very good at stabilizing the product anion and initiating deprotonation. The migrating groups (G) need to stabilize the intial anion by resonance and require G-CH3 pKa > 22 in order for the initial anion to be reactive enough for rearrangement. Products 7, 20b−d,f,g, and 23 are formed with high (10−20:1) anti diastereoselectivity. Product 23 containing the morpholine amide group is useful for preparing other carbonyl derivatives.
32 citations
TL;DR: Compound 6a has extensively inhibited the Microvessel Density or tumoral neovasculature which was evident from the CD31 immuno staining and peritoneal H&E staining, and the major reason for the antiproliferative activity of compound 6a was due to the repression of tumor vasculature.
32 citations