Morpholine

About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.

Thermal analysis of 2-oxocyclopentanedithiocarboxylato complexes of iron(iii), copper(ii) and zinc(ii) containing pyridine or morpholine as the second ligand

Abstract: A series of ternary complexes of the types M2L′2L″2;ML′2L″2 (M=Fe, Cu, Zn; L′=2-oxocyclopentane dithiocarboxylate; L″=pyridine, morpholine) and CuL′2H2O was prepared afresh. Except the iron complex, all are dimer and complexation is through the dithio moiety of the ligand L′. Their thermal decomposition was carried out in air at heating rate 10°C min−1 and it revealed that the dehydration of the aqua complex follows the same path as the carboxylates and the pyridine complexes have the tendency to follow one-step decomposition. The copper complexes are less thermally stable. The overall thermal stability of the 2-oxocyclopentanedithiocarboxylato complexes of the three metals with the volatile ligands was found to be in the order: (CuLmorph)2< CuL2H2O<(CuLpy)2<(ZnLmorph)2<(ZnLpy)2

4-phenylamino-quinazolin-6-yl-amides

Abstract: The invention provides quinazoline compounds of the formula: wherein R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) -(CH2)n-morpholino, -(CH2)n-piperidine, -(CH2)n-piperazine, -(CH2)n-piperazine-N(C1-C3 alkyl), -(CH2)n-pyrrolidine, or -(CH2)n imidazole; n is 1 to 4; R4 is -(CH2)m-Het; Het is morpholine,piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole,pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

The oxidation of phenols with copper-amine catalysts and its relation to the mode of action of tyrosinase V. Reaction mechanisms†

Abstract: The kinetic peculiarities of the conversion of monohydric phenols into orthobenzoquinone derivatives with oxygen as an oxidant and copper-morpholine complex as a catalyst may be explained, at least in a qualitative sense, by assuming the following mechanism (see Fig. 1). The primary reaction consists in the introduction of a hydroxyl group into phenol. This reaction occurs within a complex of copper with morpholine, phenol and hydrogen peroxide. The catechol formed is oxidized further, either by oxygen or by a cupric-morpholine complex, to give ortho-benzoquinone. This takes up morpholine to give the morpholinocatechol, which is subject to a rapid autoxidation to morpholino-ortho-benzoquinone. The addition of a second morpholine molecule followed by another autoxidation gives rise to the main reaction product: dimorpholino-ortho-benzoquinone. The hydrogen peroxide necessary for the primary attack upon the phenol, originates from the autoxidation of the catechols formed. The primary reaction occuring in the hypothetical copper-morpholine-phenol-hydrogen peroxide complex explains the specific ortho-oxidation as well as the exclusive activity of copper in these catalytic oxidations. The overlap of the non-hybridized 4 p orbital of the Cu atom with the electron system of the phenol and with the lone pairs of the hydrogen peroxide might have a diminishing effect upon the activation energy of the reduction-oxidation reaction in the complex.