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Motor neuron

About: Motor neuron is a research topic. Over the lifetime, 7759 publications have been published within this topic receiving 392117 citations. The topic is also known as: motoneuron & efferent neuron.


Papers
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Journal ArticleDOI
17 Jun 1994-Science
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
Abstract: Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). Expression of high levels of human SOD containing a substitution of glycine to alanine at position 93--a change that has little effect on enzyme activity--caused motor neuron disease in transgenic mice. The mice became paralyzed in one or more limbs as a result of motor neuron loss from the spinal cord and died by 5 to 6 months of age. The results show that dominant, gain-of-function mutations in SOD contribute to the pathogenesis of familial ALS.

3,958 citations

Journal ArticleDOI
29 Apr 2005-Science
TL;DR: Inferior parietal lobule neurons were studied when monkeys performed motor acts embedded in different actions and when they observed similar acts done by an experimenter to allow the observer to understand the agent's intentions.
Abstract: Inferior parietal lobule (IPL) neurons were studied when monkeys performed motor acts embedded in different actions and when they observed similar acts done by an experimenter. Most motor IPL neurons coding a specific act (e.g., grasping) showed markedly different activations when this act was part of different actions (e.g., for eating or for placing). Many motor IPL neurons also discharged during the observation of acts done by others. Most responded differentially when the same observed act was embedded in a specific action. These neurons fired during the observation of an act, before the beginning of the subsequent acts specifying the action. Thus, these neurons not only code the observed motor act but also allow the observer to understand the agent's intentions.

1,817 citations

Journal ArticleDOI
09 Aug 2002-Cell
TL;DR: It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.

1,763 citations

Journal ArticleDOI
01 Jun 1995-Neuron
TL;DR: Mutations in Cu/Zn superoxide dismutase cause a subset of cases of familial amyotrophic lateral sclerosis, and four lines of mice accumulating one of these mutant proteins (G37R) develop severe, progressive motor neuron disease.

1,470 citations

Journal ArticleDOI
05 Oct 2006-Neuron
TL;DR: In this paper, a mutant superoxide dismutase (SOD1) was found to induce non-cell-autonomous motor neuron killing by an unknown gain of toxicity.

1,372 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023158
2022533
2021226
2020233
2019293
2018241