Topic
MSH4
About: MSH4 is a research topic. Over the lifetime, 103 publications have been published within this topic receiving 13917 citations. The topic is also known as: mutS homolog 4.
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TL;DR: The current article reviews recent information on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status in an historical context.
Abstract: ▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the fundamental life processes they represent, but also because meiosis involves the formation of homolog pairs, ...
1,206 citations
TL;DR: During wild-type meiosis, recombinational interactions are differentiated into CR and NCR types very early, prior to onset of stable strand exchange and independent of SC, suggesting that SC formation may require interference.
669 citations
TL;DR: It is found that during meiosis in Saccharomyces cerevisiae, noncrossover heteroduplex products are formed at the same time as Holliday junction intermediates, and crossovers appear later, when these intermediates are resolved.
663 citations
TL;DR: A null mutation is generated in the Dmc1 gene in mice and it is shown that homozygous mutant males and females are sterile with arrest of gametogenesis in the first meiotic prophase.
578 citations
TL;DR: The different phenotypes of the three types of mutant mice suggest that these three genes may have independent functions in mammalian meiosis.
561 citations