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Murraya
About: Murraya is a research topic. Over the lifetime, 582 publications have been published within this topic receiving 7822 citations.
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TL;DR: The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine, murrayanol, and mahanine, which were mosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.
Abstract: The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their (1)H and (13)C NMR spectral data. Compound 2 showed an IC(50) of 109 microg/mL against hPGHS-1 and an IC(50) of 218 microg/mL against hPGHS-2 in antiinflammatory assays, while compound 1 displayed antioxidant activity at 33.1 microg/mL. All three compounds were mosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.
227 citations
TL;DR: In this article, the in vitro antioxidant properties of different extracts (water, alcohol, alcohol:water, hexane or chloroform extract) of curry leaves (Murraya koenigii L.) were evaluated using various assays.
190 citations
Journal Article•
TL;DR: Effect of Murraya koenigii and Brassica juncea on carbohydrate metabolism has been studied using rats as experimental animals and both showed significant hypoglycemic action.
Abstract: Effect of Murraya koenigii and Brassica juncea on carbohydrate metabolism has been studied using rats as experimental animals Both showed significant hypoglycemic action There was increase in the concentration of hepatic glycogen and glycogenesis, as evident from the increased activity of glycogen synthetase, and decrease in glycogenolysis and gluconeogenesis as evident from the decreased activity of glycogen phosphorylase and gluconeogenic enzymes
170 citations
TL;DR: Analysis of Ayurvedic Indian medicinal plants subjected to sequential solvent extraction revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
Abstract: Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic α-amylase. Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential. Of these, 6 extracts showed concentration dependent inhibition with IC50 values, namely, cold and hot water extracts from Ficus bengalensis bark (4.4 and 125 μgmL-1), Syzygium cumini seeds (42.1 and 4.1 μgmL-1), isopropanol extracts of Cinnamomum verum leaves (1.0 μgmL-1) and Curcuma longa rhizome (0.16 μgmL-1). The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract of Bixa orellana leaves (49 μgmL-1), isopropanol extract from Murraya koenigii leaves (127 μgmL-1), acetone extracts from C. longa rhizome (7.4 μgmL-1) and Tribulus terrestris seeds (511 μgmL-1). Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels. Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
161 citations
TL;DR: A benzoisofuranone derivative and a dimeric carbazole alkaloid, 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole), along with six known carbazoles alkaloids and three known steroids were isolated from the stem bark of Murraya koenigii.
157 citations