Myoglobin

About: Myoglobin is a research topic. Over the lifetime, 4377 publications have been published within this topic receiving 151708 citations. The topic is also known as: uniprot:P02144 & MB.

Ethylbenzene oxidation by a hybrid catalysis system of reconstituted myoglobin and silica-protected PdAu nanoparticles under a hydrogen-oxygen mixed atmosphere

Abstract: C–H bond oxidation using molecular oxygen as a terminal oxidant is an important reaction in molecular conversions. This reaction is achieved by several enzymes such as cytochrome P450s in biological systems, whereas artificial catalytic systems for this reaction are limited. In this work, the oxidation of ethylbenzene was promoted by a hybrid catalysis system consisting of myoglobin reconstituted with manganese porphycene as an artificial peroxygenase in combination with PdAu nanoparticles encapsulated in hollow mesoporous silica spheres as a solid catalyst to produce hydrogen peroxide, respectively. Neither catalyst alone provides hydroxylated products. Favorable conditions for hydrogen peroxide generation and subsequent C–H bond hydroxylation are different from each other and require optimization of pH and salt concentration. The optimized conditions are found to be 0.5 atm of H 2 and 0.5 atm of O 2 at pH 8.5 in the presence of 10 mM NaCl. The total optimized turnover number of the hybrid catalysis system for ethyl benzene hydroxylation is 3.6, which is consistent with 97% of the turnover number value of the same reaction catalyzed by reconstituted myoglobin using 0.5 mM hydrogen peroxide under the hydrogen-oxygen mixed atmosphere. This finding indicates that the hybrid catalyst system operates without any negative effects for both catalytic reactions.

Serum myoglobin as an early diagnostic test in acute myocardial infarction

Abstract: Acute Myocardial Infarction is one of the leading causes of death worldwide with the prevalence of approximately three million people. In this study we have investigated Biomarkers like Serum Myoglobin, Creatine kinase MB, Lactate Dehydrogenase in Acute Myocardial Infarction within four hours and after four hours of chest pain. The possible role of Serum Myoglobin as an early indicator of Acute Myocardial Infarction. To determine if there is signicant elevation of Serum Myoglobin less than four hours of Acute Myocardial Infarction and to compare it with other biomarkers of Acute Myocardial Infarction. It is a case control study done among a study population of 80 patients presenting to Emergency department of Government Theni Medical College Hospital with complains of chest pain. The study population was divided into two groups, Cases are 40 patients with chest pain less than 4 hours of duration and Controls are 40 patients with chest pain more than 4 hours of duration. Median Age group of patients in this study was between 51 to 60 years. Sig (2-tailed) test showed statistically signicant difference in all groups namely Serum Myoglobin, Creatine kinase , Lactate Dehydrogenase distribution in cases and controls with p value < 0.05. According to the present ndings in our study, the earliest Serum marker to be elevated in the case of Acute Myocardial Infarction is Serum Myoglobin.As it is not a specic marker, it can be combined with Biomarkers like Creatine Kinase and Lactate Dehydrogenase to indentify AMI at the earliest.