Nafion

About: Nafion is a research topic. Over the lifetime, 9110 publications have been published within this topic receiving 320865 citations.

Reduction of acetaminophen interference in glucose sensors by a composite Nafion membrane: demonstration in rats and man

Abstract: Amperometric glucose sensors typically monitor the production of hydrogen peroxide generated in the course of the enzymatic oxidation of glucose At the applied potential necessary to oxidize the peroxide produced, other species are also electroactive and contribute to the signal Interference of ascorbate or urate has been effectively eliminated, but that resulting from the widely used analgesic acetaminophen is not The aim of this work was to reduce this interference, which was found to be possible by introducing a membrane constructed of Nafion We compared the in vitro sensitivity to acetaminophen of five Nafion sensors with that of five non-Nafion sensors with identical glucose sensitivity (20±04 vs 19±01 nA·mmol−1· 1−1, NS): sensitivity to acetaminophen was 122±27 vs 308±63 nA·mmol−1·1−1, respectively (p<005) These sensors were tested in rats by implanting in each animal one Nafion and one non-Nafion sensors The in vivo sensitivity to glucose was similar (033±009 vs 030±005 nA·mmol−1·1−1, NS) The current generated by an acetaminophen infusion (plasma acetaminophen plateau=140±10 μmol/l) was much decreased in the case of the Nafion sensor: 05±03 vs 20±07 nA, p<005) Five Nafion sensors were implanted in the subcutaneous tissue of normal human volunteers who were given on oral dose of 500 mg acetaminophen No change in the sensor current was observed, although plasma acetaminophen reached a peak (35±6 μmol/l) at 60 min and decreased by 50% at 180 min In contrast, the current increased from 21±07 to 39±12 nA (p<005) at 60 min of a subsequent oral glucose tolerance test when plasma glucose concentration increased from 48±03 to 80±09 mmol/l This paper provides the evidence that the presence of a Nafion membrane is a solution to acetaminophen interference in glucose sensing

A polyoxometalate coupled graphene oxide–Nafion composite membrane for fuel cells operating at low relative humidity

Abstract: Polymer electrolyte fuel cells operating at elevated temperature and low relative humidity (RH) have been investigated by utilizing a polyoxometalate coupled graphene oxide–Nafion membrane. A phosphotungstic acid (PW) coupled graphene oxide–Nafion (Nafion/PW-mGO) membrane showed enhanced proton conductivity compared with pristine and recast Nafion membranes. The Nafion/PW-mGO hybrid membrane exhibited a maximum power density of 841 mW cm−2, whereas the pristine Nafion membrane showed a power density of 210 mW cm−2 operated at 80 °C under 20% RH. In comparison, our hybrid membrane showed a 4-fold higher maximum fuel cell power density when operated at 80 °C under 20% RH, than that of a state-of-the-art pristine membrane (Nafion-212). The remarkably enhanced performance of the Nafion/PW-mGO composite membrane was mainly attributed to the reduction of ohmic resistance by the hygroscopic solid acids, which can retain water in their framework through hydrogen bonding with protons at elevated temperatures and facilitates proton transport through the membrane.