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Naked eye

About: Naked eye is a(n) research topic. Over the lifetime, 1342 publication(s) have been published within this topic receiving 34880 citation(s). The topic is also known as: bare eye & unaided eye.
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Journal ArticleDOI
Roberto de la Rica1, Molly M. Stevens1Institutions (1)
TL;DR: A signal generation mechanism for biosensing is introduced that enables the detection of a few molecules of analyte with the naked eye in whole serum at the ultralow concentration of 1 × 10(-18) g ml(-1).
Abstract: A new signal generation mechanism based on the growth of gold nanoparticles offers a way to detect ultralow concentrations of analytes with the naked eye.

657 citations


Journal ArticleDOI
15 Sep 2008-Angewandte Chemie
TL;DR: This method allows the naked eye, without the aid of any advanced instrument, to assay for the presence of Cu ions by the aggregation of Au NPs as a result of the Cu(I)-catalyzed conjugation between the two functional groups.
Abstract: We report a method for the detection of Cu ions by azideand terminal alkyne-functionalized gold nanoparticles (Au NPs) in aqueous solutions using click chemistry. The catalyst, Cu(I), was conveniently derived from the reduction of Cu(II) in the presence of sodium ascorbate. This method allows the naked eye, without the aid of any advanced instrument, to assay for the presence of Cu ions by the aggregation of Au NPs as a result of the Cu(I)-catalyzed conjugation between the two functional groups. Copper is a transition metal essential for life but also highly toxic to organisms, such as certain algae, fungi and many bacteria and viruses. In recent years, copper has been suspected of causing liver damage in children. The analysis and measurement of copper in environmental and biological samples have become increasingly important. Several methods exist for the detection of Cu ions, for example, those based on organic fluorophores or chromogenic sensors, quantum dots, atomic absorption spectroscopy, inductively coupled plasma mass spectroscopy, absorbance spectro-photometry, peptides and voltammetry. The color changes associated with the aggregation of metal nanoparticles has led to the development of a number of assays for a variety of target species. Colorimetric methods can be convenient and attractive in many applications because they can be easily monitored with the naked eye, without the aid of any advanced instruments. The extinction coefficient of 13 nm-diameter gold nanoparticles is 2.7 4 10m 1 cm , several orders of magnitude more than those of traditional organic chromophores. As a result, colors arising from nanoparticles at nanomolar concentrations can be observed by the naked eye, allowing sensitive detection of small amounts of analytes. Since Cu(I) is used as a catalyst in the cycloaddition reaction between azides and alkynes in click chemistry based on Huisgen6s reaction, the amount of copper needed for its completion is typically small. Therefore, a method that can visualize the progress of the reaction using the aggregation of Au NPs might also be useful for the detection of trace amounts of Cu(II) (by detection of Cu(I)). Because the azide/alkyne functional groups and their conjugation are highly selective and are essentially inert to most biological molecules, oxygen, water, and the majority of common reaction conditions in chemical synthesis, and are tolerant of a wide range of solvents, temperatures, and pH values, we reasoned that an assay based on such chemistry may find myriad uses. Our method for the detection of Cu ions relies on the Cu(I)-catalyzed 1,3-dipolar cycloaddition of alkynes and azides on the surface of functionalized Au NPs, that results in the aggregation of Au NPs (Scheme 1). We synthesized azideand terminal alkyne-functionalized thiols, 1 and 2, and prepared gold NPs coated with these

413 citations



Journal ArticleDOI
TL;DR: The synthesis and UV-vis and NMR spectroscopic studies of thiourea-based colorimetric sensors for anions are presented, showing that these sensors can recognize anions through hydrogen binding even in competitive pH-buffered aqueous solutions.
Abstract: The synthesis and UV−vis and NMR spectroscopic studies of thiourea-based colorimetric sensors for anions are presented. These sensors can recognize anions through hydrogen binding even in competitive pH-buffered aqueous solutions, giving rise to large color changes that are clearly visible to the naked eye.

354 citations


Journal ArticleDOI
Abstract: A simple 4-Methyl-7-hydroxy-8-formyl Coumarin (CS) serves as a selective chemosensor for Mg 2+ in the presence of alkali and alkaline earth metal ions. It showed a significant fluorescence enhancement towards Mg 2+ . The receptor CS exhibited a good binding constant and lowest detection limit for Mg 2+ . The variation of emission signal exists via of reversible chelation enhanced fluorescence (CHEF) with this inherent quenching metal ion.

291 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20224
2021108
2020127
2019126
2018128
2017144

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Topic's top 5 most impactful authors

Nikhil Guchhait

12 papers, 240 citations

Cheal Kim

11 papers, 812 citations

Qi Lin

9 papers, 208 citations

Thorfinnur Gunnlaugsson

8 papers, 1.2K citations

Tai-Bao Wei

7 papers, 174 citations