Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.

Prospects of curcumin use in Nanobiotechnology

Abstract: The aim of the work was a generalization of literature data on the prospects for curcumin usage in biotechnology as a component for biologically active nanocomplexes with anti-inflammatory and antioxidant activity creation. It is emphasized that their effectiveness depends on the solubility in aqueous medium and on the metabolism rate decreasing in the body. Current trend is the development of creation methods of hydrophilic curcumin-based nanostructures to increase the time of its biological action. Its nanostructures with silicium, polylysine, copolymers of lactic and glycolic acids and metal ions are the most promising in this respect. For multicomponent hybrid nanoparticles effective usage the substantiation of their component combined use features is necessary. The practical task is to create and to study the functional properties of such combined nanocomplexes. Curcumin complex with metal ions creation contributes to its water solubility and to increase the efficiency of biological action. These complexes have specific characteristics depending on the nature of metal ion. The creation of curcumin-based biocompatible nanocomposites with amplifiers of its action that are known pharmaceuticals is perspective. Such multifunctional nanocomplexes will facilitate the targeted medicines delivery to the places of pathological processes localization and the reduction of their side effects.

Nanobiotechnology-based drug delivery strategy as a potential weapon against multiple drug-resistant pathogens

Abstract: In parallel to recent technological advancements in the clinical world, there is a rapidly growing problem of multiple drug-resistance microbial communities. In addition to human health issues, it also causes severe damage to the agriculture, veterinary, and food sectors. Nanotechnology has gained tremendous attention among the scientific community, due to its unbelievable applications and remarkable potential. Nanobiotechnology-based antimicrobial drug delivery strategies, nano-formulated antimicrobial substances, and encapsulating nanomaterials have paved the way toward nanosolution of this big challenging problem. Silver, zinc, metal oxides (titanium oxide), and magnetic nanoparticles have been synthesized by natural, synthetic, and semi-synthetic methods, and holds great promise for entrapment of antimicrobials. In vivo and in vitro experiments on different model organisms have proved the efficacy of nanomaterials and their use to restrict the aberrant microbial resistance. Significant progress has also been made to understand and improve the antimicrobial mechanism of nanostructures by drug-loaded nanoparticles and targeted delivery systems. However, designing of the nanomaterials requires in-detail knowledge of physiochemical properties and characterization of nanomaterials. This chapter presents various nanomaterials and their delivery mechanisms and it also sheds light on the future possibility of microorganisms to develop resistance, as well as risks associated with the use of nanomaterials.

Chapter 7 – Nanobiotechnology

Abstract: The main practical objectives of nanobiotechnology are using biological components to achieve nanoscale tasks. Some of these tasks are nonbiological and have applications in such areas as electronics and computing, whereas others are applicable to biology or medicine. The purpose of this chapter is to show, by selected examples, how biological approaches can contribute to nanoscience.