Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.

Green Synthesis of Bio-polymer Composites of Iron for Pharmaceutical Applications

Abstract: Due to the capacity to moderate metals to their nanometer size, nanobiotechnology is gaining enormous popularity in this period, which effectively changes its chemical, physical and optical properties. Recent progress in nanoscience and technology has also managed to the growth of new nanomaterials (NMs), eventually increasing toxic and potential health effects. There has been growing attention in evolving eco-friendly methods for metal nanoparticles (NPs) synthesis. The main purpose of the study is to reduce the harmful influences of synthetic processes, associated substances alongside other derivatives. The use of diverse biomaterials (BMs) for NP synthesis is examined as a promising method in green nanotechnology. However, most of the techniques currently available are costly; utilizing the natural properties includes plants, bacteria, fungi and algae to manufacture low-cost, non-toxic and energy-efficient metallic NPs that are environmentally friendly. Besides, biologically synthesized NPs and their characterization are essential for their future utility in numerous deliveries of drugs and pharmaceutical utilizations. Here, the current analysis summarizes the synthesis and future use of iron nanoparticles (Fe NPs) by green nanobiotechnology in the arena of biomedical applications.

Eco-friendly Approach for Silver Nanoparticles Synthesis from Lemon Extract and their Anti-oxidant, Anti-bacterial, and Anti-cancer Activities

Abstract: To create silver nanoparticles, researchers use bionanotechnology techniques because they are economical and environmentally friendly. The current study shows that lemon juice (Citrus-limon) can be used to biosynthesize silver nanoparticles (Ag NPs). The synthesized silver nanoparticles have been characterized by the surface plasmon resonance (SPR) measured at λmax = 430 nm, confirming the formation of AgNPs. Moreover, Fourier Transform Infrared (FTIR) analysis was carried out to identify possible bio-molecules responsible for the bio-reduction of silver ions. The x-ray diffraction (XRD) peaks at (111, 200, 220, 222, and 311) confirm the found face-centered cubic (FCC) crystal structure of AgNPs in solution. Transmission-Electron-Microscopy (TEM) images showed that AgNPs have spherical morphology with sizes ranging from 10-50 nm. Furthermore, the Particles Size Analyzer (PSA) confirmed these sizes and ranges. Synthesized AgNPs have high anti-oxidant activity according to the (scavenging of DPPH radicals, total anti-oxidant, and reducing power) assays. Also, the anti-bacterial activity of AgNPs was evaluated by a well diffusion method, and the results suggest that they are more sensitive to gram-positive bacteria than gram-negative ones, with the average diameter of the inhibition zones for AgNPs ranging from 4.11 to 25.87 mm and 1.38 to 22.3 mm against S. aureus and E. coli bacteria, respectively. In vitro studies of AgNPs against MCF-7 breast cancer cell s lines showed a good cytotoxic effect p<0.05 with an IC50 value of 47 μg/mL; this study could be beneficial for nanotechnology-based pharmaceutical and biomedical applications.