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Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.


Papers
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Journal ArticleDOI
TL;DR: Designs of designer self-assembling peptides have far reaching implications in a broad spectrum of applications in biology, medicine, nanobiotechnology, and nanobiomedical technology, some of which are beyond the current imaginations.
Abstract: Understanding of macromolecular materials at the molecular level is becoming increasingly important for a new generation of nanomaterials for nanobiotechnology and other disciplines, namely, the design, synthesis, and fabrication of nanodevices at the molecular scale from bottom up. Basic engineering principles for microfabrication can be learned through fully grasping the molecular self-assembly and programmed assembly phenomena. Self- and programmed-assembly phenomena are ubiquitous in nature. Two key elements in molecular macrobiological material productions are chemical complementarity and structural compatibility, both of which require weak and non-covalent interactions that bring building blocks together during self-assembly. Significant advances have been made during the 1990s at the interface of materials chemistry and biology. They include the design of helical ribbons, peptide nanofiber scaffolds for three-dimensional cell cultures and tissue engineering, peptide surfactants for solubilizing and stabilizing diverse types of membrane proteins and their complexes, and molecular ink peptides for arbitrary printing and coating surfaces as well as coiled-coil helical peptides for multi-length scale fractal structures. These designer self-assembling peptides have far reaching implications in a broad spectrum of applications in biology, medicine, nanobiotechnology, and nanobiomedical technology, some of which are beyond our current imaginations. [image: see text]

171 citations

Journal ArticleDOI
TL;DR: Here, microbeads loaded with both magnetic nanoparticles (or nanoheaters) and doxorubicin are designed to combine magnetic control of heating and drug delivery, and it is demonstrated that this new nano-in-micro platform greatly enhances the performance of encapsulated doxorbicin.
Abstract: www.MaterialsViews.com C O M M Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy U N IC A T Séverine Brulé , Michael Levy , Claire Wilhelm , Didier Letourneur , Florence Gazeau , Christine Ménager , and Catherine Le Visage * IO N In recent years, local heat generation (hyperthermia) has been tested as a means of destroying malignant tumors. Hyperthermia is a very promising treatment for cancer based on the hypothesis that cancerous cells are more sensitive to an increase of temperature than normal cells. When exposed to a high-frequency magnetic fi eld, magnetic nanoparticles generate heat through oscillation of their magnetic moment due to Neel and Brownian relaxations. [ 1 ] Direct injection of magnetic nanoparticles into solid tumors, followed by exposure to an alternating magnetic fi eld, has been shown to be capable of inducing tumor regression. [ 2 , 3 ] Ideally, the particle-induced magnetic heating should be precisely controlled, highly localized, and should result in no systemic effects and signifi cantly reduced side effects in patients. [ 4–6 ] On the other side, nanotechnology applications for anticancer drug delivery have been extensively explored, hoping to improve the effi cacy and to reduce side effects of chemotherapy. Once at the target site, the drug is released from the carrier creating a high local concentration in the tumor tissue. Nanoparticles can stimulate drug uptake by cancer cells by locally providing high extracellular concentrations of the drug and/or by direct action on the permeability of cell membranes. [ 7 ] Recently, Ciofani and coauthors hypothesized that polymeric nanoparticles with a core of magnetite and carrying specifi c drugs could be investigated for simultaneous drug targeting and hyperthermia application but they did not investigate the potential application of this system. [ 8 ] Remote-controlled degradation of degradable nanocomposite hydrogels was also obtained by application of an alternating magnetic fi eld. [ 9 ] Here, we designed microbeads loaded with both magnetic nanoparticles (or nanoheaters) and doxorubicin to combine magnetic control of heating and drug delivery. We demonstrate that this new nano-in-micro platform greatly enhances the performance of encapsulated doxorubicin

170 citations

Journal ArticleDOI
TL;DR: Molecular design using short peptides as new materials may play increasingly important role in nanoscience, nanotechnology, nanobiotechnology and nanomedicine.

169 citations

Book
03 Mar 2008
TL;DR: The role of Nanotechnology in Biological Therapies, and Personalized Medicine, and Ethical and Regulatory Aspects of Nanomedicine
Abstract: 1. Introduction 2. Nanotechnologies 3. Nanotechnologies for Basic Research Relevant to Medicine 4. Nanomolecular Diagnostics 5. Nanopharmaceuticals 6. Role of Nanotechnology in Biological Therapies 7. Nanodevices & Techniques for Clinical Applications 8. Nanooncology 9. Nanoneurology 10. Nanocardiology 11. Nanopulmonology 12. Nanoorthopedics 13. Nanoophthalmology 14. Nanomicrobiology 15. Miscellaneous Healthcare Applications of Nanobiotechnology 16. Nanobiotechnology and Personalized Medicine 17. Nanotoxicology 18. Ethical and Regulatory Aspects of Nanomedicine 19. Research and Future of Nanomedicine 20. References

169 citations

Journal ArticleDOI
Haipeng Liu1, Zhi Zhu1, Huaizhi Kang1, Yanrong Wu1, Kwame Sefan1, Weihong Tan1 
TL;DR: Cell permeability, combined with small sizes and natural nontoxicity are all excellent features that make the DNA-micelles highly suitable for a variety of applications in nanobiotechnology, cell biology, and drug delivery systems.
Abstract: Functional nanomaterials based on molecular self-assembly hold great promise for applications in biomedicine and biotechnology. However, their efficacy could be a problem and can be improved by precisely controlling the size, structure and functions. This would require a molecular engineering design capable of producing monodispersed functional materials characterized by beneficial changes in size, shape and chemical structure. To address this challenge, we have designed and constructed a series of amphiphilic oligonucleotide molecules. In aqueous solutions, the amphiphilic oligonucleotide molecules, consisting of a hydrophilic oligonucleotide covalently linked to hydrophobic diacyllipid tails, spontaneously self-assemble into monodispersed, three dimensional micellar nanostructures with a lipid core and a DNA corona. These hierarchical architectures are results of intermolecular hydrophobic interactions. Experimental testing further showed that these types of micelles have excellent thermal stability and their size can be fine tuned by changing the length of the DNA sequence. Moreover, in the micelle system, the molecular recognition properties of DNA are intact, thus, our DNA micelles can hybridize with complimentary sequences while remain their structural integrity. Importantly, when interacting with cell membranes, the highly charged DNA micelles are able to disintegrate themselves and insert into cell membrane, completing the process of internalization by endocytosis. Interestingly, the fluorescence was found accumulated in confined regions of cytosole. Finally, we show that the kinetics of this internalization process is size-dependent. Therefore, cell permeability, combined with small sizes and natural nontoxicity, are all excellent features that make our DNA-micelles highly suitable for a variety of applications in nanobiotechnology, cell biology, and drug delivery systems.

161 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202398
2022221
202144
202040
201947
201828