Topic
Nanobiotechnology
About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.
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TL;DR: In this paper, the potential of using nano-sized TiO2 in medicine and nanobiotechnology is considered, focusing on its sol-gel synthesis from different precursors.
Abstract: The published data on the preparation and the dispersion-structural properties of nano-sized TiO2 are considered. Attention is focused on its sol–gel synthesis from different precursors. The possibilities for the purposeful control and stabilization of properties of TiO2 nanopowders and sols are analyzed. Information on physicochemical methods used in studies of the particle size and the phase composition of nanodisperse TiO2 is presented. The prospects of using nano-sized TiO2 in medicine and nanobiotechnology are considered.
94 citations
TL;DR: The use of metal nanoparticles for drug delivery systems has attracted considerable research attention because of their outstanding mechanical, electromagnetic and optical properties as mentioned in this paper , which is an interdisciplinary field comprising nanomaterials, nanoelectronics, and nanobiotechnology, as three areas which extensively overlap.
Abstract: Over the past few years, nanotechnology has been attracting considerable research attention because of their outstanding mechanical, electromagnetic and optical properties. Nanotechnology is an interdisciplinary field comprising nanomaterials, nanoelectronics, and nanobiotechnology, as three areas which extensively overlap. The application of metal nanoparticles (MNPs) has drawn much attention offering significant advances, especially in the field of medicine by increasing the therapeutic index of drugs through site specificity preventing multidrug resistance and delivering therapeutic agents efficiently. Apart from drug delivery, some other applications of MNPs in medicine are also well known such as in vivo and in vitro diagnostics and production of enhanced biocompatible materials and nutraceuticals. The use of metallic nanoparticles for drug delivery systems has significant advantages, such as increased stability and half-life of drug carrier in circulation, required biodistribution, and passive or active targeting into the required target site. Green synthesis of MNPs is an emerging area in the field of bionanotechnology and provides economic and environmental benefits as an alternative to chemical and physical methods. Therefore, this review aims to provide up-to-date insights on the current challenges and perspectives of MNPs in drug delivery systems. The present review was mainly focused on the greener methods of metallic nanocarrier preparations and its surface modifications, applications of different MNPs like silver, gold, platinum, palladium, copper, zinc oxide, metal sulfide and nanometal organic frameworks in drug delivery systems.
92 citations
TL;DR: Detailed protocols for exploiting DNA nanostructures as assembly scaffolds that organize the spatial arrangements of multienzyme cascades with control over their relative distance, compartmentalization and substrate diffusion paths are presented.
Abstract: This protocol from Fu et al. describes the use of self-assembled DNA nanostructures as assembly scaffolds to spatially arrange multienzyme complexes and probe their interactions.
92 citations
TL;DR: In this article, a review of the design and biomedical application of multifunctional magnetic nanoparticles is presented, which shows that such nanoparticles could be applied to biological medical problems such as protein purification, bacterial detection, and toxin decorporation.
Abstract: The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in magnetic resonance imaging (MRI). As a result, these nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging. Because of the potential benefits of multimodal functionality in biomedical applications, researchers would like to design and fabricate multifunctional magnetic nanoparticles. Currently, there are two strategies to fabricate magnetic nanoparticle-based multifunctional nanostructures. The first, molecular functionalization, involves attaching antibodies, proteins, and dyes to the magnetic nanoparticles. The other method integrates the magnetic nanoparticles with other functional nanocomponents, such as quantum dots (QDs) or metallic nanoparticles. Because they can exhibit several features synergistically and deliver more than one function simultaneously, such multifunctional magnetic nanoparticles could have unique advantages in biomedical applications. In this Account, we review examples of the design and biomedical application of multifunctional magnetic nanoparticles. After their conjugation with proper ligands, antibodies, or proteins, the biofunctional magnetic nanoparticles exhibit highly selective binding. These results indicate that such nanoparticles could be applied to biological medical problems such as protein purification, bacterial detection, and toxin decorporation. The hybrid nanostructures, which combine magnetic nanoparticles with other nanocomponents, exhibit paramagnetism alongside features such as fluorescence or enhanced optical contrast. Such structures could provide a platform for enhanced medical imaging and controlled drug delivery. We expect that the combination of unique structural characteristics and integrated functions of multicomponent magnetic nanoparticles will attract increasing research interest and could lead to new opportunities in nanomedicine.
90 citations
TL;DR: In terms of cost-efficiency, biocompatibility, environmental friendliness, and scalability, green nanoparticle synthesis is a novel field of nanotechnology that outperforms both physical and chemical approaches as discussed by the authors .
90 citations