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Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.


Papers
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Journal ArticleDOI
TL;DR: Functionalized S-layer proteins that maintain their ability to self-assemble have led to new affinity matrices, diagnostic tools, vaccines or biocompatible surfaces, as well as to biological templating or specific biomineralisation strategies at surfaces.
Abstract: Two-dimensional bacterial cell surface layer protein crystals (S-layers) are the most commonly observed cell surface structure in bacteria and archaea. Isolated S-layer proteins have the intrinsic tendency to self-assemble into crystalline arrays in suspension and on various interfaces. Basic research on the structure, genetics, chemistry, morphogenesis and function of S-layers has led to a broad spectrum of applications in nanotechnology and biomimetics. The possibility to change the properties of S-layer proteins by genetic engineering opens new ways for tuning their functional and structural features. Functionalized S-layer proteins that maintain their ability to self-assemble have led to new affinity matrices, diagnostic tools, vaccines or biocompatible surfaces, as well as to biological templating or specific biomineralisation strategies at surfaces.

51 citations

Journal ArticleDOI
TL;DR: It is demonstrated that the largest amount of proteins adsorbed on fibers does not determine the best performance in terms of cell attachment and proliferation in vitro, which is instead related to the type of linking and the relevant role played by adsorption of serum biomolecules on the three-dimensional nanostructures.
Abstract: Polymer electrospun fibers are gaining increasing importance in nanobiotechnology, due to their intrinsic three-dimensional topography and biochemical flexibility. Here we present an in-depth study of protein functionalisation for polymethylmethacrylate fibers. We compare different coating approaches for type I collagen, including physisorption and covalent binding methods relying on functional linkers. The biofunctionalised fibers are investigated by scanning electron and confocal laser scanning microscopy, wettability measurements, Fourier-transform infrared spectroscopy, and protein quantification assays. We demonstrate that the largest amount of proteins adsorbed on fibers does not determine the best performance in terms of cell attachment and proliferation in vitro, which is instead related to the type of linking and the relevant role played by adsorption of serum biomolecules on the three-dimensional nanostructures. This study is relevant for designing and engineering novel biomaterials and scaffold architectures based on electrospun nanofibers.

51 citations

Journal ArticleDOI
TL;DR: MagPlas NPs are emerging multi-functional materials in the fields of nanoscale optoelectronics, anisotropic optics, electronics, optical sensing, and imaging and have great application potential in biomedicine and biomed...
Abstract: Most commonly magnetoplasmonic nanoparticles (MagPlas NPs) are unique composites combining magnetic and plasmonic materials within a confined nanoscale area that simultaneously show magnetic and plasmonic characteristics. They generally use Fe, Co, or Ni-based magnetic materials and noble-metal (e.g., Au, Ag, Cu, or Pt) plasmonic components, comprising a precious metal layer along a magnetic core or the inverse structure. MagPlas NPs are emerging multi-functional materials in the fields of nanoscale optoelectronics, anisotropic optics, electronics, optical sensing, and imaging. Their potential for sensing, targeting, and multimodal imaging is highly attractive for nanomedicine and nanobiotechnology. Because they possess suitable biocompatibility, MagPlas NPs have also been used in biosensor systems, hyperthermia, and magnetic resonance imaging (MRI) applications. This relatively new field of science employs MagPlas NPs in biological systems, which have great application potential in biomedicine and biomed...

49 citations

Journal ArticleDOI
19 Apr 2018-Langmuir
TL;DR: Recent studies exploring the driving interactions in nanoparticle-protein systems and resultant structures are presented, and the observed phase behavior and its dependence on various physiochemical parameters have been explained in terms of underlying interactions.
Abstract: The integration of nanoparticles with proteins is of high scientific interest due to the amazing potential displayed by their complexes, combining the nanoscale properties of nanoparticles with the specific architectures and functions of the protein molecules. The nanoparticle–protein complexes, in particular, are useful in the emerging field of nanobiotechnology (nanomedicine, drug delivery, and biosensors) as the nanoparticles having sizes comparable to that of living cells can access and operate within the cell. The understanding of nanoparticle interaction with different protein molecules is a prerequisite for such applications. The interaction of the two components has been shown to result in conformational changes in proteins and to affect the surface properties and colloidal stability of the nanoparticles. In this feature article, our recent studies exploring the driving interactions in nanoparticle–protein systems and resultant structures are presented. The anionic colloidal silica nanoparticles a...

48 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202398
2022221
202144
202040
201947
201828