Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.

Microbial bionanotechnology : biological self-assembly systems and biopolymer-based nanostructures

Abstract: Part 1: Biopolymer-Based Structures 1. Biopolyester Particles Produced by Microbes or Using Polyester Synthases: Self-Assembly and Potential Applications 2. Bionanofabrication: A Tool for Creating Unique Structures through in Vitro Polymer Synthesis 3. Polyhydroxyalkanoates in Nanobiotechnology: Application to Protein-Protein Interaction Studies 4. Cyanophycin Inclusions: Biosynthesis and Applications 5. Biomineralisation of Magnetosomes in Bacteria: Nanoparticles with Potential Application 6. Microbial Production of Alginates: Self-Assembly and Applications Part 2: Protein- and DNA-Based Structures 7. Bacteriophages: Self-Assembly and Applications 8. Molecular Biomimetics: Linking Polypeptides to Inorganic Structures 9. Bacterial Spores in Bionanotechnology 10. Supramolecular Assembly Using the Natural Specificities of Biological Macromolecules 11. Bacterial Protein Complexes with Potential Applications in Nanotechnology 12. S-Layer Proteins: Potential Applications in Nano(bio)technology 13. Bacteriorhodopsin

A novel nonviral nanoparticle gene vector: Poly-L-lysine-silica nanoparticles

Abstract: DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomateial—poly-L-lysine-silica nanoparticles (PLL-SiNP) was prepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that PLL-SiNP could efficiently transfer PEGFPC-2 plasmid DNA into HNE1 cell line. These results indicated that PLL-SiNP was a novel nonviral nanoparticle gene vector, and would probably play an important role in gene structure and function research as well as gene therapy.

Recent advances in nanotechnology for eradicating bacterial biofilm

Abstract: Microorganisms grouped together into spatially-organized communities called biofilms, are the cause of dramatic chronic infections in plants, animals and humans. In this review, the characteristics of biofilms and their interactions with antimicrobials are first described. Limitations of antibiotic treatments are discussed, and state-of-the-art alternative approaches based on the use of polymer, lipid, organic, inorganic and hybrid nanoparticles are presented, highlighting recent achievements in the application of nanomaterials to the field of theranostics for the eradication of biofilm. The aim of this review is to present a complete vision of nanobiotechnology-based approaches for eradicating bacterial biofilms and fighting antimicrobial tolerance.