Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.

Dispersion‒corrected DFT investigations on the interaction of glycine amino acid with metal organic framework MOF‒5

Abstract: The emerging field of nanobiotechnology has recently paid great deals of attention to the interface at which biomolecules interact with the surface of nanostructures to fabricate functional materials. In this work, the interaction between glycine and metal organic frameworks (MOFs) was investigated using dispersion-corrected DFT (DFT‒D3) calculations. Strong interactions were predicted between the glycine and MOF-5 at the interaction energy of −45.251 kcal/mol. The accuracy of the current method was verified by experimental data and second-order Moller-Plesset perturbation theory. Electronic structures and atoms-in-molecules (AIM) analysis of the interface region indicated that the glycine tends to establish chemical bonds with the MOF-5. Furthermore, a strong interaction was observed between the tripeptide and MOF-5, mimicking the behavior of realistic biological systems. These results pave the way for further realistic investigations into the biomolecular‒nanostructured material complexes for the purpose of developing nano-scaled drug delivery systems.

Physical and Chemical Nature of Nanoparticles

Abstract: Nanoparticles have some specific features, including physical properties, chemical properties, merits, and demerits, which have drawn much attention for their application in nanobiotechnology. This chapter explains the state of the art of different properties of nanoparticles and their potential beneficial roles. In addition, this chapter discusses on the research on nanoparticles essentiality for plants and describes the current knowledge concerning the key nanoparticles with important studies for their future applications.

Dispersion‒corrected DFT investigations on the interaction of glycine amino acid with metal organic framework MOF‒5

Abstract: The emerging field of nanobiotechnology has recently paid great deals of attention to the interface at which biomolecules interact with the surface of nanostructures to fabricate functional materials. In this work, the interaction between glycine and metal organic frameworks (MOFs) was investigated using dispersion-corrected DFT (DFT‒D3) calculations. Strong interactions were predicted between the glycine and MOF-5 at the interaction energy of −45.251 kcal/mol. The accuracy of the current method was verified by experimental data and second-order Møller-Plesset perturbation theory. Electronic structures and atoms-in-molecules (AIM) analysis of the interface region indicated that the glycine tends to establish chemical bonds with the MOF-5. Furthermore, a strong interaction was observed between the tripeptide and MOF-5, mimicking the behavior of realistic biological systems. These results pave the way for further realistic investigations into the biomolecular‒nanostructured material complexes for the purpose of developing nano-scaled drug delivery systems.

Macrophomina phaseolina : microbased biorefinery for gold nanoparticle production

Abstract: Biofabrication of nanoparticles via the principles of green nanotechnology is a key issue addressed in nanobiotechnology research. There is a growing need for development of a synthesis method for producing biocompatible stable nanoparticles in order to avoid adverse effects in medical applications. We report the use of simple and rapid biosynthesis method for the preparation of gold nanoparticles using Macrophomina phaseolina (Tassi) Goid, a soil-borne pathogen. The effect of pH and temperature on the synthesis of gold nanoparticles by M. phaseolina was also assessed. Different techniques like UV-Visible Spectroscopy, Transmission Electron Microscopy (TEM), Dynamic light scattering (DLS) measurements, Fourier transform infrared (FTIR), and EDX were used to characterize the gold nanoparticles. The movement of these gold nanoparticles inside Escherichia coli (ATCC11103) along with effect on growth and viability was evaluated. The biogenic gold nanoparticle was synthesized at 37 °C temperature and neutral pH. UV-Visible Spectroscopy, TEM, EDX, and DLS measurements confirm the formation of 14 to 16 nm biogenic gold nanoparticles. FTIR substantiates the presence of protein capping on Macrophomina phaseolina-mediated gold nanoparticles. The non-toxicity of gold nanoparticles was confirmed by the growth and viability assay while the TEM images validated the entry of gold nanoparticles without disrupting the structural integrity of E. coli. Biogenic method for the synthesis of nanoparticles using fungi is novel, efficient, without toxic chemicals. These biogenic gold nanoparticles themselves are nontoxic to the microbial cells and offer a better substitute for drug delivery system.