Nanobiotechnology

About: Nanobiotechnology is a research topic. Over the lifetime, 796 publications have been published within this topic receiving 46309 citations. The topic is also known as: bionanotechnology & nanobiology.

Designing synthetic RNA for delivery by nanoparticles.

Abstract: The rapid development of synthetic biology and nanobiotechnology has led to the construction of various synthetic RNA nanoparticles of different functionalities and potential applications. As they occur naturally, nucleic acids are an attractive construction material for biocompatible nanoscaffold and nanomachine design. In this review, we provide an overview of the types of RNA and nucleic acid's nanoparticle design, with the focus on relevant nanostructures utilized for gene-expression regulation in cellular models. Structural analysis and modeling is addressed along with the tools available for RNA structural prediction. The functionalization of RNA-based nanoparticles leading to prospective applications of such constructs in potential therapies is shown. The route from the nanoparticle design and modeling through synthesis and functionalization to cellular application is also described. For a better understanding of the fate of targeted RNA after delivery, an overview of RNA processing inside the cell is also provided.

A proactive model on innovative biomedical applications of gold nanoparticles

Abstract: Nanobiotechnology is the emerging field of science as it deals with the properties on nanoscale dimension and it can make the revolution in the diagnostic and therapeutic fields. The purpose of this review is to summarize the synthesis, types, properties and applications of gold nanoparticles. Gold nanoparticles are widely studied metal nanoparticles because of their unique physical and chemical properties that are different from bulk materials. Gold nanoparticles possess notable optoelectronic properties that are dependent on the shape and size of nanoparticles. They have large surface-to-volume ratio, excellent biocompatibility, and low toxicity which are very useful and make them an important tool in nanobiotechnology. This review reveals the characterization of gold nanoparticles by using UV–Vis spectroscopy, TEM and DLS. For their ability to target and efficient drug delivery, they have been extensively used for enhanced radiation in the field of radiation therapy. Gold nanoparticles have several other applications in the biomedical field like detection of very sensitive analytes, protein and virus and even they play role in killing cancer cells by hyperthermal treatment. A time is not far for fabrication and manipulation of new nanomaterials to be engineered for applications including therapeutic delivery, biosensors and bioimaging for biomedical use.

Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control.

Abstract: This paper provides a concise review on the recent development of nanoscale hybrid systems based on carbon nanotubes (CNTs) for biological sensing and control. CNT-based hybrid systems have been intensively studied for versatile applications of biological interfaces such as sensing, cell therapy and tissue regeneration. Recent advances in nanobiotechnology not only enable the fabrication of highly sensitive biosensors at nanoscale but also allow the applications in the controls of cell growth and differentiation. This review describes the fabrication methods of such CNT-based hybrid systems and their applications in biosensing and cell controls.

Optimization of Ag2O nanostructures with strontium for biological and therapeutic potential.

Abstract: Pristine- and strontium-doped Ag2O nanoparticles (NPs) were synthesized utilizing the symbolic co-precipitation method, in which sodium hydroxide was used as a precipitating agent. Various instrume...