Topic
Nanogel
About: Nanogel is a research topic. Over the lifetime, 2053 publications have been published within this topic receiving 59235 citations. The topic is also known as: nanogel.
Papers published on a yearly basis
Papers
More filters
TL;DR: Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.
1,704 citations
TL;DR: This review describes the recent developments of microgel/nanogel particles as drug delivery carriers for biological and biomedical applications, including stability for prolonged circulation in the blood stream, novel functionality for further bioconjugation, and biodegradability for sustained release of drugs for a desired period of time.
1,444 citations
TL;DR: This work has shown that polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins.
Abstract: Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer chains. They are developed as carriers for the transport of drugs, and can be designed to spontaneously incorporate biologically active molecules through formation of salt bonds, hydrogen bonds, or hydrophobic interactions. Polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins. The guest molecules interact electrostatically with the ionic polymer chains of the gel and become bound within the finite nanogel. Multiple chemical functionalities can be employed in the nanogels to introduce imaging labels and to allow targeted drug delivery. The latter can be achieved, for example, with degradable or cleavable cross-links. Recent studies suggest that nanogels have a very promising future in biomedical applications.
1,069 citations
TL;DR: A new family of nanoscale materials on the basis of dispersed networks of cross-linked ionic and nonionic hydrophilic polymers is being developed, one example is the nanosized cationic network ofcross-linked poly(ethylene oxide) and polyethyleneimine, PEO-cl-PEI nanogel, which has a potential of enhancing oral and brain bioavailability of oligonucleotides.
701 citations
TL;DR: Recent exciting developments in click hydrogels, microgels and nanogels, as well as their biomedical applications such as controlled protein and drug release, tissue engineering, and regenerative medicine are presented and discussed.
599 citations