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Nanomedicine
About: Nanomedicine is a research topic. Over the lifetime, 4287 publications have been published within this topic receiving 200647 citations.
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TL;DR: The molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine are discussed.
Abstract: Diagnostic- and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these “human-non-self” modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.
102 citations
TL;DR: This paper briefly focuses on several anticancer agents and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
Abstract: This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparti- cles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxoru- bicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
102 citations
TL;DR: This review focuses on the potential of nanomedicine, including the development of nanoparticles for diagnostic and screening purposes, DNA sequencing using nanopores, manufacture of drug delivery systems and single-virus detection.
Abstract: Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications, genomics and robotics. Without doubt, one of the greatest values of nanotechnology will be in the development of new and effective medical treatments (i.e., nanomedicine). This review focuses on the potential of nanomedicine, including the development of nanoparticles for diagnostic and screening purposes, DNA sequencing using nanopores, manufacture of drug delivery systems and single-virus detection.
102 citations
TL;DR: A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier, exhibiting high in vitro and in vivo efficacies of CO therapy.
101 citations
TL;DR: This review is an attempt to highlight the possible applications of nanotechnology and the use of nanomaterials in dentistry.
Abstract: The human body comprises molecules; hence, the availability of molecular nanotechnology will permit dramatic progress to address medical problems and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine could develop devices that are able to work inside the human body in order to identify the early presence of a disease, and to identify and quantify toxic molecules and tumor cells, for example. Nanodentistry will make possible the maintenance of comprehensive oral health by employing nanomaterials, including tissue engineering and, ultimately, dental nanorobots. This review is an attempt to highlight the possible applications of nanotechnology and the use of nanomaterials in dentistry.
101 citations