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Nanomedicine

About: Nanomedicine is a research topic. Over the lifetime, 4287 publications have been published within this topic receiving 200647 citations.


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Journal ArticleDOI
TL;DR: This review consolidates studies on different types of anticancer drug loaded in PPI dendrimers as well as PPI-immunobiosensors that are currently being explored for better cancer diagnosis and targeting.

62 citations

Journal ArticleDOI
TL;DR: This work presents a facile method to fabricate NMOP-PEG with multi-component structures as a biodegradable, multifunctional nanoplatform for multimodal image-guided combination cancer therapy and achieves excellent tumor killing efficacy through in vivo photothermal and radiation synergistic therapy in mouse tumor model experiments.
Abstract: Nanoscale metal-organic particles (NMOPs) have recently shown great promise in the area of nanomedicine owing to their tunable compositions, highly enriched functionalities, well-defined sizes/shapes and intrinsic biodegradability. Herein, we describe the fabrication of NMOPs with both core-shell and co-doped structures via a post-synthesis cation exchange method for applications in multimodal imaging and combined photothermal and radiation therapy of cancer. Template NMOPs containing Mn2+ and IR825, a near-infrared (NIR) dye, are first synthesized and then mixed with Hf4+ to obtain core-shell and co-doped Mn/Hf-IR825 NMOPs depending on the dose of added Hf4+ ions. In these NMOPs, Mn2+ offers strong T1 magnetic resonance (MR) contrast, Hf4+ is a high-Z element with excellent computed tomography signal enhancement ability and radio-sensitization capability, and IR825 exhibits rather high NIR absorbance. After coating with polydopamine (PDA) and further conjugation with polyethylene glycol (PEG), the co-doped Mn/Hf-IR825@PDA-PEG particles (NMOP-PEG) showed efficient tumor-homing ability after intravenous injection, as illustrated by MR and photoacoustic (PA) imaging. Utilizing NMOP-PEG achieved excellent tumor killing efficacy through in vivo photothermal and radiation synergistic therapy in our mouse tumor model experiments. Importantly, our NMOP-PEG showed no appreciable toxicity to the treated mice and could be efficiently excreted. Our work presents a facile method to fabricate NMOP-PEG with multi-component structures as a biodegradable, multifunctional nanoplatform for multimodal image-guided combination cancer therapy. Nanoparticles that offer imaging-guided attacks on cancer cells using both photothermal and radiation therapies are now possible. Zhuang Liu from Soochow University in China and colleagues aimed to solve several issue affecting clinical cancer treatments by tailoring materials known as nanoscale metal-organic frameworks. Through cation exchange, the team added hafnium — a metal that strongly absorbs X-ray radiation — to a manganese–organic dye framework capable of providing magnetic resonance images and directing photothermal energy to tumours. After applying a polymer coating to improve physiological stability, the team injected the nanoparticles in mouse models and activated them with a laser. These experiments revealed the nanomedicine had a high tumour killing efficacy due to its multiple modes of action. Cytotoxicity in the trials was minimal, with all nanoparticles excreted from the mice within one month. Core-shell & co-doping nanoscale metal-organic particles (NMOPs), with high strong NIR absorbance, high radio-sensitizing capability and intrinsic biodegradability are developed via a post-synthesis cation exchange strategy for multimodal imaging guided synergistic thermo-radiotherapy. After coating with polydopamine and further conjugation with polyethylene glycol (PEG), such NMOP-PEG nanoparticles show effective tumor retention, and could be utilized for effective synergistic thermo-radiotherapy of cancer. Importantly, those NMOPs show no appreciable toxicity to the treated mice, and could be rapidly excreted from the body owing to their biodegradability.

62 citations

Journal ArticleDOI
TL;DR: The use of pharmacological inhibition to probe internalization and intracellular trafficking pathways of nanoparticles is critically evaluated and approaches to target-specific delivery of therapeutics via nanoparticles into the cytoplasm and nucleus are addressed.
Abstract: Nanomaterials promise to improve disease diagnosis and treatment by enhancing the delivery of drugs, genes, biomolecules and imaging agents to specific subcellular targets. In order to optimize nanomaterial design for this purpose, a comprehensive understanding of how these materials are taken up and transported within the cell is required. In this review, we discuss the endocytic pathways employed by different types of nanoparticles with emphasis on the influence of nanoparticle surface modification. The use of pharmacological inhibition to probe internalization and intracellular trafficking pathways of nanoparticles is critically evaluated. Finally, approaches to target-specific delivery of therapeutics via nanoparticles into the cytoplasm and nucleus are addressed.

62 citations

Journal ArticleDOI
TL;DR: The present review summarizes the most important steps carried-out by the group of Prof Blanco-Prieto in nanomedicine and drug delivery technologies and shows that drug delivery systems combined with cell therapy can achieve a more complete and potent regenerative response.
Abstract: Nanomedicine and drug delivery technologies play a prominent role in modern medicine, facilitating better treatments than conventional drugs. Nanomedicine is being increasingly used to develop new methods of cancer diagnosis and treatment, since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs, thereby reducing their toxicity. Regenerative medicine provides another area where innovative drug delivery technology is being studied for improved tissue regeneration. Drug delivery systems can protect therapeutic proteins and peptides against degradation in biological environments and deliver them in a controlled manner. Similarly, the combination of drug delivery systems and stem cells can improve their survival, differentiation, and engraftment. The present review summarizes the most important steps carried-out by the group of Prof Blanco-Prieto in nanomedicine and drug delivery technologies. Throughout her scientific career, she has contributed to the area of nanomedicine to improve anticancer therapy. In particular, nanoparticles loaded with edelfosine, doxorubicin, or methotrexate have demonstrated great anticancer activity in preclinical settings of lymphoma, glioma, and pediatric osteosarcoma. In regenerative medicine, a major focus has been the development of drug delivery systems for brain and cardiac repair. In this context, several microparticle-based technologies loaded with biologics have demonstrated efficacy in clinically relevant animal models such as monkeys and pigs. The latest research by this group has shown that drug delivery systems combined with cell therapy can achieve a more complete and potent regenerative response. Cutting-edge areas such as noninvasive intravenous delivery of cardioprotective nanomedicines or extracellular vesicle-based therapies are also being explored. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

62 citations

Journal ArticleDOI
TL;DR: The most salient examples of phosphorus dendrimers used for the elaboration of bio-chips and of supports for cell cultures, for imaging biological events, and for carrying and delivering drugs or biomacromolecules are presented in this paper.

62 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023999
20221,773
2021431
2020402
2019364
2018317