Topic
Nanomedicine
About: Nanomedicine is a research topic. Over the lifetime, 4287 publications have been published within this topic receiving 200647 citations.
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TL;DR: It is found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
Abstract: A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
292 citations
TL;DR: This review focuses on the potential of nanomedicine as it specifically relates to the development of nanoparticles for enabling and improving the targeted delivery of therapeutic agents and developing novel and more effective diagnostic and screening techniques to extend the limits of molecular diagnostics.
292 citations
TL;DR: This review is focused on the problems encountered in oral chemotherapy and the pharmaceutical nanotechnology solutions such as prodrugs, nanoemulsions, dendrimers, micelles, liposomes, solid lipid nanoparticles and nanoparticles of biodegradable polymers.
290 citations
TL;DR: Successful clinically approved cancer nanodrugs as well as promising candidates in the pipeline are discussed, categorized according to whether they predominantly exploit multifunctionality, unique electromagnetic properties, or distinct transport characteristics in the body.
285 citations
TL;DR: The analysis and control of the electrospinning process is described, and the types of electrospun fibers fabricated for biomedical applications such as drug delivery and tissue engineering are described.
Abstract: The fact that in vivo the extracellular matrix (ECM) or substratum with which cells interact often includes topography at the nanoscale underscores the importance of investigating cell-substrate interactions and performing cell culture at the submicron scale. An important and exciting direction of research in nanomedicine would be to gain an understanding and exploit the cellular response to nanostructures. Electrospinning is a simple and versatile technique that can produce a macroporous scaffold comprising randomly oriented or aligned nanofibers. It can also accommodate the incorporation of drug delivery function into the fibrous scaffold. Endowed with both topographical and biochemical signals such electrospun nanofibrous scaffolds may provide an optimal microenvironment for the seeded cells. This review covers the analysis and control of the electrospinning process, and describes the types of electrospun fibers fabricated for biomedical applications such as drug delivery and tissue engineering.
281 citations