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Nanomedicine

About: Nanomedicine is a research topic. Over the lifetime, 4287 publications have been published within this topic receiving 200647 citations.


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Journal ArticleDOI
TL;DR: This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery, and review recent advances in major NP based biomedical applications.
Abstract: This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

925 citations

Journal ArticleDOI
TL;DR: There is still significant room for development, as researchers continue to refine existing workflows while finding new and exciting applications that can take advantage of this developing technology, cell‐membrane‐coating nanotechnology.
Abstract: Nanoparticle-based therapeutic, prevention, and detection modalities have the potential to greatly impact how diseases are diagnosed and managed in the clinic. With the wide range of nanomaterials available, the rational design of nanocarriers on an application-specific basis has become increasingly commonplace. Here, a comprehensive overview is provided on an emerging platform: cell-membrane-coating nanotechnology. As a fundamental unit of biology, cells carry out a wide range of functions, including the remarkable ability to interface and interact with their surrounding environment. Instead of attempting to replicate such functions via synthetic techniques, researchers are now directly leveraging naturally derived cell membranes as a means of bestowing nanoparticles with enhanced biointerfacing capabilities. This top-down technique is facile, highly generalizable, and has the potential to greatly augment existing nanocarriers. Further, the introduction of a natural membrane substrate onto nanoparticles surfaces has enabled additional applications beyond those traditionally associated with nanomedicine. Despite its relative youth, there exists an impressive body of literature on cell membrane coating, which is covered here in detail. Overall, there is still significant room for development, as researchers continue to refine existing workflows while finding new and exciting applications that can take advantage of this developing technology.

908 citations

Journal ArticleDOI
TL;DR: Drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect.

907 citations

Journal ArticleDOI
TL;DR: From the Institute of Biomaterials and Biomedical Engineering (B.Y.S.K., J.T.R., W.W.C.C.), Terrence Donnelly Centre for Cellular and Biomolecular Research, and the Department of Chemical Engineering.
Abstract: From the Institute of Biomaterials and Biomedical Engineering (B.Y.S.K., W.C.W.C.), Terrence Donnelly Centre for Cellular and Biomolecular Research (B.Y.S.K., W.C.W.C.), the Department of Materials Science and Engineering (W.C.W.C.), and the Department of Chemical Engineering (W.C.W.C.), University of Toronto (B.Y.S.K., J.T.R., W.C.W.C.); and the Division of Neurosurgery (B.Y.S.K., J.T.R.) and the Arthur and Sonia Labatt Brain Tumour Research Centre ( J.T.R.), Hospital for Sick Children (B.Y.S.K., J.T.R.) — both in Toronto. Address reprint requests to Dr. Chan at the Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, 164 College St., 407, University of Toronto, Toronto, ON M5S 3G9, Canada, or at warren.chan@ utoronto.ca.

878 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023999
20221,773
2021431
2020402
2019364
2018317