Topic
Nasal glial heterotopia
About: Nasal glial heterotopia is a research topic. Over the lifetime, 47 publications have been published within this topic receiving 541 citations. The topic is also known as: Nasal glioma.
Papers
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TL;DR: The nasal encephalocele, the glioma, and the dermoid are the most common of the congenital midline nasal masses and each may be associated with bony cranial defects and intracranial abnormalities, as well as CSF leakage and the potential for fatal meningitis if not handled properly.
Abstract: The nasal encephalocele, the glioma, and the dermoid are the most common of the congenital midline nasal masses. Due to similar embryologic development, each of these lesions may be associated with bony cranial defects and intracranial abnormalities, as well as CSF leakage and the potential for fatal meningitis if not handled properly. Properative manipulation should be avoided. Radiologic studies are instructive only if they are positive. If intracranial attachments are identified radiologically or suspected clinically, neurosurgical consultation should be obtained, and intracranial exploration and resection should be carried out as the initial procedure. Extra-cranial resection of the remaining mass may be performed immediately after intracranial resection, may be postponed, or may become unnecessary.
187 citations
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TL;DR: The biology of nasal glioma and encephalocele is reviewed and an algorithm for preoperative evaluation and surgical management is presented to present.
Abstract: Objective: To review the biology of nasal glioma and encephalocele and to present an algorithm for preoperative evaluation and surgical management. Design: Retrospective review and analysis. Setting: Tertiary care medical center: 1970 to 2002. Patient: Sixteen patients with glioma (n = 10) and encephalocele (n = 6). Outcome: Age at the time of presentation, sex, signs and symptoms, imaging findings, surgical approach, pathology, complications, rate of recurrence, and follow-up were recorded. Results: Ten patients presented with nasal glioma with a mean age of 9 months. All patients underwent surgical excision. No complication was encountered with a mean follow-up of 3.5 years. Six patients presented with encephaloceles with a mean age of 15.5 months. All patients underwent surgical excision. Complications included cerebrospinal fluid leak (n = 1) and epiphora (n = 1). Follow-up was 1 to 14 years (mean, 4 years). Conclusion: Nasal glioma and encephalocele are rare, benign, congenital lesions with a potential for intracranial extension. Evaluation should include a complete rhinologic and neurologic examination. Preoperative imaging with a thin-cut axial and coronal computed tomography scan andlor multiplanar magnetic resonance imaging is essential. Surgical intervention should be performed soon after diagnosis to alleviate the increased risk of meningitis. A frontal craniotomy approach is recommended if intracranial extension is identified based on preoperative evaluation, followed by an extracranial resection. If there is no evidence of intracranial extension, a conservative extracranial approach is recommended.
111 citations
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TL;DR: Ten cases of nasal glial heterotopic diagnosed between 1970 and 2000 were identified and patient follow-up was obtained, with most patients presenting clinically with a polypoid mass in the nasal cavity, although two patients had a mass on the nasal bridge.
74 citations
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TL;DR: In this paper, a clinical, morphological, ultrastructural and immunohistochemical study is made of two cases of nasal glioma, one associated with agenesis of the corpus callosum.
Abstract: The term nasal glioma has been used to describe a congenital benign tumor of the nasal region containing neural tissue. The nature of these lesions remains open to controversy, because of the different locations of the heterotopic neural tissue involved, the deficient development of the bony structures and the persistence or not of the structural relations with the central nervous system. More recent terms define these lesions as ectopic nervous tissue. A clinical, morphological, ultrastructural and immunohistochemical study is made of two cases of nasal glioma, one associated with agenesis of the corpus callosum. In this case, the mother had been treated with clomiphene. In such cases, morphological and immunohistochemical findings support that "nasal glioma" remain valid as a descriptive term defining a congenital benign tumor composed of heterotopic neural tissue within the nasal region and covered by skin, that may recur following incomplete surgical resection.
32 citations
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TL;DR: A case of fetal nasal glioma diagnosed at 21 weeks of gestation, which excluded the possibility of an encephalocele by ruling out underlying bone defects and was resected without complications at 4 months of age.
Abstract: We report a case of fetal nasal glioma diagnosed at 21 weeks of gestation. The glioma appeared as a moderately hypoechoic mass arising from the junction between the medial aspect of the left orbit and the lateral aspect of the nose, and showing no internal vascularization on color and power Doppler ultrasonography. Fetal magnetic resonance imaging (MRI) excluded the possibility of an encephalocele by ruling out underlying bone defects. After an uneventful pregnancy, the nasal glioma was resected without complications at 4 months of age. The differential diagnosis of fetal paranasal facial masses is discussed.
21 citations