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Nephropathia epidemica

About: Nephropathia epidemica is a research topic. Over the lifetime, 400 publications have been published within this topic receiving 14039 citations.


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Journal ArticleDOI
TL;DR: There are few available data about the clinical picture of confirmed Saaremaa infections, but epidemiological evidence suggests that it is less pathogenic than Dobrava, and that SaareMAa infections are more similar to nephropathia epidemica caused by Puumala.
Abstract: Hantaviruses are enveloped RNA viruses each carried by a specific rodent species. Three hantaviruses, Puumala, Dobrava, and Saaremaa viruses, are known to cause haemorrhagic fever with renal syndrome. In Europe. Puumala causes a generally mild disease, nephropathia epidemica, which presents most commonly with fever, headache, gastrointestinal symptoms, impaired renal function, and blurred vision, whereas Dobrava infections often also have haemorrhagic complications. There are few available data about the clinical picture of confirmed Saaremaa infections, but epidemiological evidence suggests that it is less pathogenic than Dobrava, and that Saaremaa infections are more similar to nephropathia epidemica caused by Puumala. Along with its rodent host, the bank vole (Clethrionomys glareolus), Puumala is reported throughout most of Europe (excluding the Mediterranean region), whereas Dobrava, carried by the yellow-necked mouse (Apodemus flavicollis), and Saaremaa, carried by the striped field mouse (Apodemus agrarius), are reported mainly in eastern and central Europe. The diagnosis of acute hantavirus infection is based on the detection of virus-specific IgM. Whereas Puumala is distinct, Dobrava and Saaremaa are genetically and antigenically very closely related and were previously thought to be variants of the same virus. Typing of a specific hantavirus infection requires neutralisation antibody assays or reverse transcriptase PCR and sequencing.

541 citations

Journal ArticleDOI
TL;DR: The identification in 1993 of Sin Nombre virus (SN) as the causative agent of hantavirus-associated pulmonary syndrome (HPS) led to intensive search for further hantviruses and as a result today a total of as many as 16 well-established sero/genotypes may be listed.
Abstract: Introduction. The isolation by Ho Wang Lee and collaborators of the virus causing Korean haemorrhagic fever, now called Hantaan virus (HTN), from the lungs of striped field mice (Apodemus agrarius) in 1976 (Lee & Lee, 1976) launched a new era in the study of haemorrhagic fever with renal syndrome (HFRS) throughout the world. This was soon followed by the discovery of the causative agent of the European form of HFRS, nephropathia epidemica, now known as Puumala virus (PUU) (Brummer-Korvenkontio et al., 1980), and of the urban rat virus, Seoul virus (SEO) (Lee et al., 1980). The identification in 1993 of Sin Nombre virus (SN) as the causative agent of hantavirus-associated pulmonary syndrome (HPS) (Nichol et al., 1993a) led to intensive search for further hantaviruses and as a result today a total of as many as 16 well-established sero/genotypes may be listed.

403 citations

Journal ArticleDOI
TL;DR: An indirect immunofluorescence test for detection of serum antibodies specific for nephropathia epidemica (NE) has been developed with use of acetone-fixed cryostat sections of the lungs of bank voles that had been trapped from the NE-endemic area in Finland as antigen.
Abstract: An indirect immunofluorescence test for detection of serum antibodies specific for nephropathia epidemica (NE) has been developed with use of acetone-fixed cryostat sections of the lungs of bank voles (Clethrionomys glareolus) that had been trapped from the NE-endemic area in Finland as antigen. NE antigen was detected as distinct fluorescence in the cytoplasm of alveolar and macrophage-like cells. The 16 patients studied included typical cases from an endemic area, cases from a family outbreak, and cases in a laboratory staff which had had close contact with infected bank voles. Antibodies reacting with antigen in the lung sections developed in all of the patients, but they were not found in the preimmune sera of the patients, in the sera of patients with other renal diseases, or in the sera of healthy individuals, with the exception of a member of the laboratory staff who had lived in the endemic area for 20 years. No specific IgM antibodies to NE could be detected. The rise in titer of antibodies to NE was characteristically prolonged, and elevated antibody levels persisted for many years.

399 citations

Journal ArticleDOI
01 Mar 1985-Science
TL;DR: Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.
Abstract: Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.

392 citations

Journal ArticleDOI
TL;DR: It is concluded that hantaviruses have a significant impact on public health in Europe and no vaccine or specific therapy is in general use in Europe.
Abstract: Hantaviruses (genus Hantavirus, family Bunyaviridae) are enveloped tri-segmented negative-stranded RNA viruses each carried by a specific rodent or insectivore host species. Several different hantaviruses known to infect humans circulate in Europe. The most common is Puumala (PUUV) carried by the bank vole; another two important, genetically closely related ones are Dobrava-Belgrade (DOBV) and Saaremaa viruses (SAAV) carried by Apodemus mice (species names follow the International Committee on Taxonomy of Viruses nomenclature). Of the two hantaviral diseases, hemorrhagic fever with renal syndrome (HFRS) and hantaviral cardiopulmonary syndrome, the European viruses cause only HFRS: DOBV with often severe symptoms and a high case fatality rate, and PUUV and SAAV more often mild disease. More than 10,000 HFRS cases are diagnosed annually in Europe and in increasing numbers. Whether this is because of increasing recognition by the medical community or due to environmental factors such as climate change, or both, is not known. Nevertheless, in large areas of Europe, the population has a considerable seroprevalence but only relatively few HFRS cases are reported. Moreover, no epidemiological data are available from many countries. We know now that cardiac, pulmonary, ocular and hormonal disorders are, besides renal changes, common during the acute stage of PUUV and DOBV infection. About 5% of hospitalized PUUV and 16%-48% of DOBV patients require dialysis and some prolonged intensive-care treatment. Although PUUV-HFRS has a low case fatality rate, complications and long-term hormonal, renal, and cardiovascular consequences commonly occur. No vaccine or specific therapy is in general use in Europe. We conclude that hantaviruses have a significant impact on public health in Europe.

264 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20219
20208
20197
20184
201713
201611