Nervous system

Abstract: The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections. The hermaphrodite nervous system has a total complement of 302 neurons, which are arranged in an essentially invariant structure. Neurons with similar morphologies and connectivities have been grouped together into classes; there are 118 such classes. Neurons have simple morphologies with few, if any, branches. Processes from neurons run in defined positions within bundles of parallel processes, synaptic connections being made en passant. Process bundles are arranged longitudinally and circumferentially and are often adjacent to ridges of hypodermis. Neurons are generally highly locally connected, making synaptic connections with many of their neighbours. Muscle cells have arms that run out to process bundles containing motoneuron axons. Here they receive their synaptic input in defined regions along the surface of the bundles, where motoneuron axons reside. Most of the morphologically identifiable synaptic connections in a typical animal are described. These consist of about 5000 chemical synapses, 2000 neuromuscular junctions and 600 gap junctions.

Abstract: Vasculature O.U. Scremin, Cerebral Vascular System. Spinal Cord and Peripheral Nervous System C. Molander and G. Grant, Spinal Cord Cytoarchitecture. A. Ribeiro-da-Silva, Substantia Gelantinosa of Spinal Cord. G. Grant, Primary Afferent Projections to the Spinal Cord. D.J. Tracey, Ascending and Descending Pathways in the Spinal Cord. G. Gabella, Autonomic Nervous System. Brainstem and Cerebellum C.B. Saper, CentralAutonomic System. G. Holstege, The Basic, Somatic, and Emotional Components of the Motor System in Mammals. B.E. Jones, Reticular Formation: Cytoarchitecture, Transmitters, and Projections. A.J. Beitz, Periaqueductal Gray. G. Aston-Jones, M.T. Shipley, and R. Grzanna, The Locus Coeruleus, A5 and A7 Noradrenergic Cell Groups. J.H. Fallon and S.E. Loughlin, Substantia Nigra. J.B. Travers, Oromotor Nuclei. G. Holstege, B.F.M. Blok, and G.J. ter Horst, Brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition. T.J.H. Ruigrok and F. Cella, Precerebellar Nuclei and Red Nucleus. J. Voogd, Cerebellum. Forebrain R.B. Simerly, Anatomical Substrates of Hypothalamic Integration. W.E. Armstrong, Hypothalamic Supraoptic and Paraventricular Nuclei. B.J. Oldfield and M.J. McKinley, Circumventricular Organs. R.L. Jakab and C. Leranth, Septum. D.G. Amaral and M.P. Witter, Hippocampal Formation. G.F. Alheid, J.S. de Olmos, and C.A. Beltramino, Amygdala and Extended Amygdala. L. Heimer, D.S. Zahm, and G.F. Alheid, Basal Ganglia. J.L. Price, Thalamus. K. Zilles and A. Wree, Cortex: Areal and Laminar Structure. Sensory Systems D.J. Tracey and P.M.E. Waite, Somatosensory System. P.M.E. Waite and D.J. Tracey, Trigeminal Sensory System. W.D. Willis, K.N. Westlund, and S.M. Carlton, Pain. R. Norgren, Gustatory System. J.A. Rubertone, W.R. Mehler, and J. Voogd, The Vestibular Nuclear Complex. W.R. Webster, Auditory System. A.J. Sefton and B. Dreher, Visual System. M.T. Shipley, J.H. McLean, and M. Ennis, Olfactory System. Neurotransmitters G. Halliday, A. Harding, and G. Paxinos, Serotonin and Tachykinin Systems. S.E. Loughlin, F.M. Leslie, and J.H. Fallon, Endogenous Opioid Systems. L.L. Butcher, Cholinergic Neurons and Networks. O.P. Ottersen, O.P. Hjelle, K.K. Osen, and J.H. Laake, Amino Acid Transmitters. Development S.A. Bayer and J. Altman, Neurogenesis and Neuronal Migration. S.A. Bayer and J. Altman, Principles of Neurogenesis, Neuronal Migration, and Neural Circuit Formation. Subject Index.

Abstract: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of receptor tyrosine kinases and p75NTR, a member of the TNF receptor superfamily. Through these, neurotrophins activate many signaling pathways, including those mediated by ras and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and Jun kinase cascades. During development, limiting amounts of neurotrophins function as survival factors to ensure a match between the number of surviving neurons and the requirement for appropriate target innervation. They also regulate cell fate decisions, axon growth, dendrite pruning, the patterning of innervation and the expression of proteins crucial for normal neuronal function, such as neurotransmitters and ion channels. These proteins also regulate many aspects of neural function. In the mature nervous system, they control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.

Abstract: Incidence pathogenesis and other general aspects experimental tumours of the nervous system tumours of central neuroepithelial origin tumours of specialized tissues of central neuroepithelial origin the growth of dissemination of central neuroepithelial tumours tumours of the meninges and related tissues tumours of the cranial, spinal and peripheral nerve sheaths nervous system involvement by lymphomas, histiocytoses and leukaemias tumours of vascular origin tumours and tumour-like lesions of maldevelopmental origin dysgenetic syndromes (phacomatoses) associated with tumours and hamartomas of the nervous system secondary tumours of the nervous system deformations and other structural changes produced by intercranial tumours effects of radiation and other forms of therapy on intracranial and spinal tumours and their surrounding tissues tumours of peripheral neuroblasts and ganglion cells paragangliomas.