scispace - formally typeset
Search or ask a question
Topic

Nervous system

About: Nervous system is a research topic. Over the lifetime, 16729 publications have been published within this topic receiving 847181 citations.


Papers
More filters
Book
15 Jan 1991
TL;DR: The best ebooks about Fine Structure Of the Nervous System Neurons And Their Supporting Cells that you can get for free here by download this Fine structure of the nervous systemNeurons and their free ebooks.
Abstract: The best ebooks about Fine Structure Of The Nervous System Neurons And Their Supporting Cells that you can get for free here by download this Fine Structure Of The Nervous System Neurons And Their Supporting Cells and save to your desktop. This ebooks is under topic such as fine structure of the nervous system neurons and their fine structure of the nervous systemneurons and their free ebooks fine structure of the nervous system: neurons the fine structure of the nervous system: neurons and nervous tissue and nervous system springer immunocytochemical characterization of supporting cells in the enteric nervous system annual reviews dendrites: a key structural element of neurons 8 bardet-biedl syndrome and the neuronal primary cilium dmca / copyrighted works removal download lymphoma and leukemia of the nervous system pdf lab 10 – nervous tissue nervous tissue vmicroiusmiu morphology of the mammalian olfactory epithelium: form chapt 41 hbio nervous system walkersclass morphology of the mammalian olfactory epithelium: form 7 nervous tissue, overview of the nervous system nervous system [ch 48] biologysc

1,439 citations

Journal ArticleDOI
14 Aug 2003-Nature
TL;DR: It is demonstrated that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactileAllodynia in normal animals, suggesting that blocking P1X4 receptors in microglial might be a new therapeutic strategy for pain induced by nerve injury.
Abstract: Pain after nerve damage is an expression of pathological operation of the nervous system, one hallmark of which is tactile allodynia-pain hypersensitivity evoked by innocuous stimuli. Effective therapy for this pain is lacking, and the underlying mechanisms are poorly understood. Here we report that pharmacological blockade of spinal P2X4 receptors (P2X4Rs), a subtype of ionotropic ATP receptor, reversed tactile allodynia caused by peripheral nerve injury without affecting acute pain behaviours in naive animals. After nerve injury, P2X4R expression increased strikingly in the ipsilateral spinal cord, and P2X4Rs were induced in hyperactive microglia but not in neurons or astrocytes. Intraspinal administration of P2X4R antisense oligodeoxynucleotide decreased the induction of P2X4Rs and suppressed tactile allodynia after nerve injury. Conversely, intraspinal administration of microglia in which P2X4Rs had been induced and stimulated, produced tactile allodynia in naive rats. Taken together, our results demonstrate that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals. Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury.

1,420 citations

Journal ArticleDOI
TL;DR: It was difficult to identify substance-P immunoreactive axons in the rats studied, and further experimental studies are necessary to elucidate the projections of the substance P-immunoreactive neurons in the rat central nervous system.

1,403 citations

Journal ArticleDOI
TL;DR: It is no longer appropriate to consider solely neuron–neuron connections; it is also necessary to develop a view of the intricate web of active connections among glial cells, and between glia and neurons.
Abstract: Glial cells are emerging from the background to become more prominent in our thinking about integration in the nervous system. Given that glial cells associated with synapses integrate neuronal inputs and can release transmitters that modulate synaptic activity, it is time to rethink our understanding of the wiring diagram of the nervous system. It is no longer appropriate to consider solely neuron–neuron connections; we also need to develop a view of the intricate web of active connections among glial cells, and between glia and neurons. Without such a view, it might be impossible to decode the language of the brain.

1,385 citations


Network Information
Related Topics (5)
Hippocampus
34.9K papers, 1.9M citations
82% related
Glutamate receptor
33.5K papers, 1.8M citations
82% related
Disease
47.9K papers, 1.8M citations
81% related
Dopamine
45.7K papers, 2.2M citations
80% related
Embryonic stem cell
35.1K papers, 1.9M citations
80% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023247
2022510
2021371
2020409
2019375
2018357