Topic
Nervous system
About: Nervous system is a research topic. Over the lifetime, 16729 publications have been published within this topic receiving 847181 citations.
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TL;DR: The existence of epidermal nerve fibers will necessitate changes in present theory of structure and function of peripheral sensation, and these nerves appear to have a three-dimensional territorial distribution in relationship to the skin's surface.
285 citations
TL;DR: This work highlights parallels between the control of phenotypic expression in the nervous and hematopoietic systems and between the cytokines involved in the immune response and the response of the nervous system to injury and a potential role for cytokines in synaptic plasticity.
285 citations
TL;DR: Results suggest a function for neurofibromin in the normal nervous system in some NF1 disease manifestations, such as Schwann cell tumors and learning disabilities, which may result from abnormalities in the cells that express neurof fibromin.
285 citations
TL;DR: The current understanding of the extracellular matrix, its receptors, and its functions in the nervous system are discussed and significant progress has been made recently in characterizing both ECM constituents and their receptors inThe nervous system.
Abstract: Extracellular matrix molecules help regulate many aspects of neural development, including survival, migration, axon growth, and synapse formation by neurons. These same molecules have been shown to modulate regeneration of neurons after injuries. They also regulate the development and differentiation of other neural cells, such as astroglia and Schwann cells. Significant progress has been made recently in characterizing both ECM constituents and their receptors in the nervous system. Extracellular matrix molecules promote cell adhesion, activate intracellular signaling pathways, and modulate the activities of several growth factors and proteins. Our current understanding of the extracellular matrix, its receptors, and its functions in the nervous system are discussed.
285 citations
TL;DR: This review explores how proprioceptive sensory information is organized at spinal cord levels as it relates to a sense of body position and movement and develops a different framework that may be more in tune with current views of sensorimotor processing in other central nervous system structures.
Abstract: This review explores how proprioceptive sensory information is organized at spinal cord levels as it relates to a sense of body position and movement. The topic is considered in an historical context and develops a different framework that may be more in tune with current views of sensorimotor processing in other central nervous system structures. The dorsal spinocerebellar tract (DSCT) system is considered in detail as a model system that may be considered as an end point for the processing of proprioceptive sensory information in the spinal cord. An analysis of this system examines sensory processing at the lowest levels of synaptic connectivity with central neurons in the nervous system. The analysis leads to a framework for proprioception that involves a highly flexible network organization based in some way on whole limb kinematics. The functional organization underlying this framework originates with the biomechanical linkages in the limb that establish functional relationships among the limb segments. Afferent information from limb receptors is processed further through a distributed neural network in the spinal cord. The result is a global representation of hindlimb parameters rather than a muscle-by-muscle or joint-by-joint representation.
285 citations