Nervous system

TL;DR: It is shown that nSR100 regulates an extensive network of brain-specific alternative exons enriched in genes that function in neural cell differentiation and acts by increasing the levels of the neural/brain-enriched polypyrimidine tract binding protein and by interacting with its target transcripts.

TL;DR: It is shown that the switch in response to MAG from promotion to inhibition of neurite outgrowth by DRg neurons occurs sharply at Postnatal Day 3, and that MAG is likely to contribute to the lack of regeneration observed throughout the nervous system.

TL;DR: This article focuses on a few examples of nervous system diseases where the contribution of NMDARs is relatively well characterized and discusses the implications for potential treatment of these illnesses.

TL;DR: GPR126 has domain-specific functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas the CTF promotes wrapping through cAMP elevation, and this work suggests a model in which Laminin-211 mediates GPR126-induced cAMP levels to control early and late stages of SC development.

TL;DR: The results suggest intranasally applied macromolecules may bypass the blood-brain barrier and rapidly enter the primate CNS along olfactory- and trigeminal-associated extracellular pathways, as shown previously in the rat.