Topic
Nervous system
About: Nervous system is a research topic. Over the lifetime, 16729 publications have been published within this topic receiving 847181 citations.
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TL;DR: Evidence has accumulated that suggests heterogeneity of astrocytes across brain regions as well as within the same brain regions, which will greatly aid investigation of the function of astracytes in normal brain aswell as the roles of astrospecies in neurological disorders.
492 citations
TL;DR: Recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease are reviewed.
491 citations
TL;DR: Analysis of the mutant in the olfactory bulb suggests that the mutant phenotype involves a defect in cell migration, possibly through specific loss of the polysialylated form of N-CAM-180, which is expressed in the migration pathway.
487 citations
Journal Article•
TL;DR: Tumours of the nervous system of animals are not as rare as has been commonly believed, but in dogs, especially the brachycephalic breeds, these tumours occur as frequently as in man.
Abstract: Tumours of the nervous system of animals are not as rare as has been commonly believed. In dogs, especially the brachycephalic breeds, these tumours occur as frequently as in man. The tumours are grouped according to tissue of origin as follows: nerve cells, neuroepithelium, glia, peripheral nerves and nerve sheaths, meninges and vessels, the pineal and pituitary glands, and the craniopharyngeal duct. Tumours of the glia are relatively common and are divided into the following types: astrocytoma, oligodendroglioma, glioblastoma, spongioblastoma, medulloblastoma, and unclassified gliomas.
487 citations
TL;DR: The mutant mouse described here will help to elucidate the functions of L1 in the nervous system and how these depend on genetic influences.
Abstract: The adhesion molecule L1 is a member of the immunoglobulin super-family1. L1 is involved in various recognition processes in the CMS and PNS2–3, and binding to L1 can activate signal transduction pathways4,5. Mutations in the human L1 gene are associated with a variable phenotype, including mental retardation and anomalous development of the nervous system, referred to as ‘CRASH’ (corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus)6. We generated an animal model of these conditions by gene targeting. Mutant mice were smaller than wild-type and were less sensitive to touch and pain, and their hind-legs appeared weak and uncoordinated. The size of the corticospinal tract was reduced and, depending on genetic background, the lateral ventricles were often enlarged. Non-myelinating Schwann cells formed processes not associated with axons and showed reduced association with axons. In vitro, neurite outgrowth on an L1 substrate and fasciculation were impaired. The mutant mouse described here will help to elucidate the functions of L1 in the nervous system and how these depend on genetic influences.
487 citations