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Neural crest formation

About: Neural crest formation is a research topic. Over the lifetime, 188 publications have been published within this topic receiving 28567 citations.


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MonographDOI
28 Nov 1999
TL;DR: The Neural Crest is a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life as discussed by the authors, and the ontogeny of the neural crest embodies the most important issues in developmental biology.
Abstract: This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.

2,869 citations

Journal ArticleDOI
28 Sep 2000-Nature
TL;DR: In Xenopus embryos, LRP6 activated Wnt–Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation, indicating that LRP 6 may be a component of the Wnt receptor complex.
Abstract: The Wnt family of secreted signalling molecules are essential in embryo development and tumour formation The Frizzled (Fz) family of serpentine receptors function as Wnt receptors, but how Fz proteins transduce signalling is not understood In Drosophila, arrow phenocopies the wingless (DWnt-1) phenotype, and encodes a transmembrane protein that is homologous to two members of the mammalian low-density lipoprotein receptor (LDLR)-related protein (LRP) family, LRP5 and LRP6 (refs 12-15) Here we report that LRP6 functions as a co-receptor for Wnt signal transduction In Xenopus embryos, LRP6 activated Wnt-Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation An LRP6 mutant lacking the carboxyl intracellular domain blocked signalling by Wnt or Wnt-Fz, but not by Dishevelled or beta-catenin, and inhibited neural crest development The extracellular domain of LRP6 bound Wnt-1 and associated with Fz in a Wnt-dependent manner Our results indicate that LRP6 may be a component of the Wnt receptor complex

1,348 citations

Journal ArticleDOI
TL;DR: The EMT events that build the embryo are reviewed and two prototypical processes governed by EMT in amniotes are discussed: gastrulation and neural crest formation.
Abstract: The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.

1,242 citations

Journal ArticleDOI
22 Sep 1995-Cell
TL;DR: The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants and appear to be initiated at the neural plate stage and to involve the opponent activities of a BMP-mediated dorsalizing signal from the epidermal ectoderm and a SHH-mediated ventralizing signalFrom the notochord.

1,080 citations

Journal ArticleDOI
06 May 1994-Science
TL;DR: Early chick embryos were incubated with antisense oligonucleotides to chick Slug to inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed.
Abstract: Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.

766 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20218
20205
20197
20185
20177
20165