Topic
Neurosphere
About: Neurosphere is a research topic. Over the lifetime, 5145 publications have been published within this topic receiving 321088 citations.
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TL;DR: A genetic marking strategy is developed for lineage tracing of individual, quiescent, and nestin-expressing radial glia-like (RGL) precursors in the adult mouse dentate gyrus and identifies RGLs as self-renewing and multipotent neural stem cells and provides novel insights into in vivo properties of adult neural stem Cells.
763 citations
TL;DR: Using cell surface markers and flow cytometry, isolated neural crest stem cells from mammalian fetal peripheral nerve are isolated and in vivo BrdU labeling indicates that these stem cells self-renew in vivo.
760 citations
TL;DR: In normal brain, the side population (SP) phenotype is generated by ABC transporter activity and identifies stem cell and endothelial cell subpopulations by dye exclusion, and is increased in nonendothelial cells that form neurospheres and are highly tumorigenic.
756 citations
TL;DR: It is found that almost all radial glial cells proliferate throughout neurogenesis and three distinct subsets identified by immunostaining for the antigens RC2, the astrocyte-specific glutamate transporter (GLAST), and the brain-lipid-binding protein (BLBP) are identified.
750 citations
TL;DR: It is reported that nerve growth factor controls the proliferation of neuronal precursors in a defined culture system of cells derived from the early embryonic brain.
Abstract: Nerve growth factor plays an important part in neuron-target interactions in the late embryonic and adult brain. We now report that this growth factor controls the proliferation of neuronal precursors in a defined culture system of cells derived from the early embryonic brain. Neuronal precursor cells were identified by expression of the intermediate filament protein nestin. These cells proliferate in response to nerve growth factor but only after they have been exposed to basic fibroblast growth factor. On withdrawal of nerve growth factor, the proliferative cells differentiate into neurons. Thus, in combination with other growth factors, nerve growth factor regulates the proliferation and terminal differentiation of neuroepithelial stem cells.
741 citations