Showing papers on "Nigella damascena published in 2019"
TL;DR: The previously reported anti-inflammatory activity of damascenine and β-elemene investigated in murine models was confirmed in this study on human neuthrophils suggesting their possible strong inhibitory effect on inflammatory response progression.
20 citations
TL;DR: The white-flower cultivar contained anthocyanins analogous to those of the blue flowers but at very low levels, and the same three flavonols were detected in the rose-pink, blue, and white flowers.
4 citations
11 May 2019
TL;DR: It was found out that a course administration of the fatty oil extract from the seeds of Nigella damascena L. promotes the correction of lipid metabolism disorders under the conditions of acute Tween lipidopathy, while the direction of the object being studied reduces the concentration of cholesterol and triglycerides in the liver and blood serum under the Conditions of subchronic dyslipidemia.
Abstract: The aim of the study is to determine a lipid spectrum of blood plasma and liver in rats in with simulated dyslipidemia against the background of the administration of the fatty oil extract from the seeds of Nigella damascena L. Materials and methods. Laboratory animals – Wistar male rats – were used in the work. To study the hypolipidemic activity, such models as acute Tween, subchronic vitamin-D2 models and a model of chronic heart failure were used. The identifiable parameters were the concentration of cholesterol and triglycerides in the blood serum and liver, as well as the concentration of atherogenic and non-atherogenic lipoproteins in the blood serum, and the atherogenic coefficient. Results. As a result of the study, it was found out that a course administration of the fatty oil extract from the seeds of Nigella damascena L. against the background of simulated chronic heart failure (CHF) by the right ventricular type, normalizes the lipid spectrum of the experimental animals’ blood serum, causing an increase in the concentration of high-density (non-atherogenic) lipoproteins, and reduces the concentration of low-density (atherogenic) lipoproteins. A single administration of the fatty oil extract from the seeds of Nigella damascena L. promotes the correction of lipid metabolism disorders under the conditions of acute Tween lipidopathy, while the direction of the object being studied reduces the concentration of cholesterol and triglycerides in the liver and blood serum under the conditions of subchronic dyslipidemia. At the same time, the effect of the use of the fatty oil extract from the seeds of Nigella damascena L. was not inferior to “Omaсor”, the reference drug. Conclusion. The possibility of using a fatty oil extract from the seeds of Nigella damascena L. for preventive and therapeutic aims in cardiovascular diseases has been established.
1 citations
Patent•
08 Feb 2019
TL;DR: In this paper, a method of immunocorrection using extracts of fatty oils from seeds of Nigella damascena and Echinacea purpurea, including reproducing immune deficiency in laboratory rats by administering cyclophosphamide once in a dose of 200 mg/kg per the rat body weight, was described.
Abstract: FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and is intended for immunocorrection. Method of immunocorrection using extracts of fatty oils from seeds of Nigella damascena and Echinacea purpurea, including reproducing immune deficiency in laboratory rats by administering cyclophosphamide once in a dose of 200 mg/kg per the rat body weight on the first day of the experiment with the subsequent correction on the second day of the experiment, is characterized in that the correction of immune deficiency is carried out with a mixture of extracts of fatty oils from seeds of seeds of Nigella damascena and Echinacea purpurea at a volume ratio of 1:1, which is intragastrically administered to the laboratory rat, through a probe, in a dose of 4.6 ml/kg/day daily for 14 days.EFFECT: described method of immunocorrection with a combination of components of the mixture provides a synergetic effect and effective correction of experimental immune deficiency.1 cl, 1 tbl, 1 ex